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Central nervous system drugs

Carbidopa

Also known as Lodosyn, Carbidopa anhydrous, (S)-carbidopa

CAS 28860-95-9Formula C10H14N2O4Molar mass 226.23 g/molEC 249-271-9
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 90 suppliers listed Drug substance
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Carbidopa chemical structure, C10H14N2O4, CAS 28860-95-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
28860-95-9
Formula
C10H14N2O4
Molar mass
226.23 g/mol
EC number
249-271-9
HS code
292800
Category
Central nervous system drugs

What is Carbidopa?

Plain description, key identifiers and synonyms

Carbidopa (anhydrous) is 3-(3,4-Dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used (commonly as its hydrate) in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an antiparkinson drug, a dopaminergic agent and an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor. It is a member of hydrazines, a monocarboxylic acid and a member of catechols.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
CAS number
28860-95-9 CAS number cross-checkedOther or deprecated CAS: 1426847-87-1, 38821-49-7
EC numbers
249-271-9, 657-445-4
Molecular formula
C10H14N2O4
UNII
KR87B45RGH
MDL number
MFCD00069231
InChIKey
TZFNLOMSOLWIDK-JTQLQIEISA-N
InChI
InChI=1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1
Canonical SMILES
CC(Cc1ccc(O)c(O)c1)(NN)C(=O)O
Isomeric SMILES
C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)NN

Synonyms

  • Lodosyn
  • Carbidopa anhydrous
  • (S)-carbidopa
  • (S)-(-)-carbidopa
  • N-Aminomethyldopa
  • alpha-Methyldopahydrazine
  • Carbidopum
  • L-alpha-Methyldopahydrazine
  • Carbidopa (anhydrous)
  • (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
  • MK 486
  • L-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid
  • (-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid
  • (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid
  • (-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate
  • Benzenepropanoic acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, (S)-
  • Carbidopum monohydrate
  • Methyldopahydrazine
  • Dhivy component carbidopa
  • Duopa component carbidopa
  • Rytary component carbidopa
  • Crexont component carbidopa
  • Stalevo component carbidopa
  • Corbilta component carbidopa
  • Carbidopa Tablets
Show all 36 synonyms
  • Levodopa/carbidopa/entacapone orion component carbidopa
  • L-Carbidopa Anhydrous
  • Carbidopa Tablets, 25 mg
  • (2S)-2-(azaniumylamino)-3-(3,4-dihydroxyphenyl)-2-methylpropanoate
  • Benzenepropanoic Acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-,(S)-
  • (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate
  • Benzenepropanoic acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, monohydrate, (S)-
  • S-(-)-Carbidopa
  • (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid
  • S(-)-carbidopa
  • (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
226.23 g/molcalc.
Exact mass
226.0954 Dacalc.
LogP (octanol/water)
-0.05calc.
Topological polar surface area
115.8 Ųcalc.
Hydrogen bond donors
5calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
16calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.3calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H351Suspected of causing cancer.
  • H360May damage fertility or the unborn child.
Precautionary statements (18)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Carbidopa suppliers

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All 90 suppliers
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Where suppliers are based

90 suppliers in 17 countries

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Carbidopa price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Antiparkinson Agents
  • Aromatic Amino Acid Decarboxylase Inhibitors
  • Dopamine Agents

Roles

  • antidyskinesia agent
  • antiparkinson drug
  • dopaminergic agent
  • enzyme inhibitor
  • neurotransmitter agent
  • pharmaceutical

Pharmacology

Carbidopa is an Aromatic Amino Acid Decarboxylation Inhibitor. The mechanism of action of carbidopa is as a DOPA Decarboxylase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Carbidopa is traded under.

HS 2928.00Indicative HS code

Organic derivatives of hydrazine or of hydroxylamine

World exports in 2024
$1.38B
−9.0% vs 2023, imports $1.52B
2019 to 2024
Top exporters
  1. Switzerland * partner reported44.0%
  2. China18.4%
  3. Italy9.4%
Top importers
  1. Brazil21.8%
  2. United States12.8%
  3. Italy10.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Carbidopa is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Carbidopa, based on the data on this page

What is Carbidopa?

Carbidopa (anhydrous) is 3-(3,4-Dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine.

What is the CAS number of Carbidopa?

The CAS registry number of Carbidopa is 28860-95-9. Other or deprecated CAS numbers: 1426847-87-1, 38821-49-7.

What is the molecular formula and weight of Carbidopa?

The molecular formula of Carbidopa is C10H14N2O4 and its molar mass is 226.23 g/mol.

What is Carbidopa used for?

Use classes: Pharmaceuticals.

Is Carbidopa hazardous?

Carbidopa carries the GHS signal word "Danger". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Carbidopa?

Carbidopa is usually classified under HS code 292800 (Organic derivatives of hydrazine or of hydroxylamine). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Carbidopa?

CompoundList lists 90 suppliers of Carbidopa in United States, China, India, Germany and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Carbidopa in India?

10 suppliers in India list Carbidopa on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Carbidopa?

Suppliers quote Carbidopa on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Carbidopa

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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