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Cardiovascular and metabolic drugs

Methyldopa

Also known as Alphamethyldopa, Dopamet, Presolisin

CAS 555-30-6Formula C10H13NO4Molar mass 211.22 g/molEC 209-089-2
GHS signal word: Warning. Pictograms: Serious health hazard 103 suppliers listed Drug substance
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Methyldopa chemical structure, C10H13NO4, CAS 555-30-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Minute, anhyd crystals from methanol
Melting point
300 °C
Solubility
Sol in water @ 25 °C: approx 10 mg/ml /D-form/
HS code
292250
Category
Cardiovascular and metabolic drugs
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Methyldopa?

Plain description, key identifiers and synonyms

Alpha-methyl-L-dopa is a derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring. It has a role as an alpha-adrenergic agonist, an antihypertensive agent, a peripheral nervous system drug, a hapten and a sympatholytic agent. It is a L-tyrosine derivative and a non-proteinogenic L-alpha-amino acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
CAS number
555-30-6 CAS number cross-checkedOther or deprecated CAS: 27289-76-5, 41372-08-1, 88620-56-8
EC number
209-089-2
Molecular formula
C10H13NO4
UNII
M4R0H12F6M
MDL number
MFCD00004186
InChIKey
CJCSPKMFHVPWAR-JTQLQIEISA-N
InChI
InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1
Canonical SMILES
CC(N)(Cc1ccc(O)c(O)c1)C(=O)O
Isomeric SMILES
C[C@](CC1=CC(=C(C=C1)O)O)(C(=O)O)N

Synonyms

  • Alphamethyldopa
  • Dopamet
  • Presolisin
  • Medomet
  • Alpha medopa
  • l-alpha-Methyldopa
  • Methyldopa anhydrous
  • Aldometil
  • Methoplain
  • Sedometil
  • Dopatec
  • Hyperpax
  • Methyl dopa
  • alpha-Methyl dopa
  • Sembrina
  • Hypolag
  • Dopegyt
  • Medopren
  • Presinol
  • alpha-Methyl-L-dopa
  • L-Methyl Dopa
  • Metildopa
  • L-(alpha-Md)
  • Methyl-L-dopa
  • Methyldopum
Show all 39 synonyms
  • Dopegit
  • (S)-(-)-alpha-Methyldopa
  • Bayer 1440 L
  • 3-Hydroxy-alpha-methyl-L-tyrosine
  • Aldomin
  • L-Methyldopa
  • Anhydrous methyldopa
  • Lederdopa
  • alpha-Methyldihydroxyphenylalanine
  • l-3-(3,4-Dihydroxyphenyl)-2-methylalanine
  • alpha-Methyl-L-3,4-dihydroxyphenylalanine
  • L-alpha-Methyl-3,4-dihydroxyphenylalanine
  • Methyldopa, anhydrous
  • BAYER-1440L

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Minute, anhyd crystals from methanolexp.
Odour
ODORLESSexp.
Taste
ALMOST TASTELESSexp.
Melting point
300 °Cexp.
Solubility
Sol in water @ 25 °C: approx 10 mg/ml /D-form/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
211.22 g/molcalc.
Exact mass
211.0845 Dacalc.
LogP (octanol/water)
0.44calc.
Topological polar surface area
103.8 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
15calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.3calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (5)
  • P203Obtain, read and follow all safety instructions before use.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Methyldopa suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 103 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

103 suppliers in 19 countries

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Methyldopa price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Antihypertensive agent.

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Adrenergic alpha-2 Receptor Agonists
  • Antihypertensive Agents
  • Sympatholytics

Roles

  • adrenergic agent
  • adrenergic agonist
  • alpha-adrenergic agonist
  • alpha-adrenergic drug
  • antihypertensive agent
  • cardiovascular drug
  • hapten
  • hypoglycemic agent
  • neurotransmitter agent
  • peripheral nervous system drug
  • pharmaceutical
  • sympatholytic agent

Pharmacology

Methyldopa anhydrous is a Central alpha-2 Adrenergic Agonist. The mechanism of action of methyldopa anhydrous is as an Adrenergic alpha2-Agonist.

How it is made

Pfister, Stein, US patent 2,868,818 (1959 to Merck & Co). Resolution: Jones et al, US patent 3,158,648 (1964 to Merck & Co), Compare Slates et al, J Org Chem 29, 1424 (1964). ... Synth from asymmetric intermediates: Reinhold et al, J Org Chem 33, 1209 (1968).

The product of the reaction of 3,4-dimethoxyphenylacetonitrile with sodium ethoxide is hydrolyzed with acid to give 3,4-dimethoxyphenylacetone. This is reacted with ammonium carbonate and potassium cyanide to form a substituted hydantoin intermediate which, on alkaline hydrolysis, yields racemic methyldopa. The acetylated form of this racemate is resolved using (-)-alpha-methylbenzylamine. The isolated acetylated (-)-methyldopate salt is deacetylated with base and treated with mineral acid to liberate (-)-methyldopa. US Pat 2,868,818

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Methyldopa is traded under.

HS 2922.50Indicative HS code

Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function

World exports in 2024
$3.29B
−5.9% vs 2023, imports $3.19B
2019 to 2024
Top exporters
  1. China39.2%
  2. United Kingdom27.1%
  3. India * partner reported4.8%
Top importers
  1. United States20.7%
  2. Germany7.6%
  3. Italy6.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Methyldopa is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Methyldopa, based on the data on this page

What is Methyldopa?

Alpha-methyl-L-dopa is a derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring. It has a role as an alpha-adrenergic agonist, an antihypertensive agent, a peripheral nervous system drug, a hapten and a sympatholytic agent.

What is the CAS number of Methyldopa?

The CAS registry number of Methyldopa is 555-30-6. Other or deprecated CAS numbers: 27289-76-5, 41372-08-1, 88620-56-8.

What is the molecular formula and weight of Methyldopa?

The molecular formula of Methyldopa is C10H13NO4 and its molar mass is 211.22 g/mol.

What is Methyldopa used for?

Antihypertensive agent. Use classes: Pharmaceuticals.

Is Methyldopa hazardous?

Methyldopa carries the GHS signal word "Warning". Main hazards: suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Methyldopa?

Methyldopa is usually classified under HS code 292250 (Amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Methyldopa?

CompoundList lists 103 suppliers of Methyldopa in China, United States, India, Germany and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Methyldopa in India?

10 suppliers in India list Methyldopa on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Methyldopa?

Suppliers quote Methyldopa on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Methyldopa

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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