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Central nervous system drugs

Chloroethane

Also known as Ethyl chloride, Ethane, chloro-, Chelen

CAS 75-00-3Formula C2H5ClMolar mass 64.52 g/molEC 200-830-5
GHS signal word: Danger. Pictograms: Flammable, Gas under pressure, Serious health hazard 38 suppliers listed
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Chloroethane chemical structure, C2H5Cl, CAS 75-00-3
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless liquid
Melting point
-138.7 °C
Boiling point
12.3 °C
Density
Relative density (water = 1): 0.918
Flash point
-50 °C
HS code
290311
Category
Central nervous system drugs
UN number
UN 1037
Illustrative photo, clear liquid in a volumetric flask on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Chloroethane?

Plain description, key identifiers and synonyms

Chloroethane is the simplest and least toxic member of the class of chloroethanes, that is ethane in which a single hydrogen is substituted by a chlorine. A colourless gas at room temperature and pressure (boiling point 12C), it is used as a mild topical anaesthetic to numb the skin prior to ear piercing, skin biopsies, etc., and is also used in the treatment of sports injuries. It was formerly used in the production of tetraethyllead. It has a role as a local anaesthetic, an inhalation anaesthetic and an antipruritic drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
chloroethane
CAS number
75-00-3 CAS number cross-checkedOther or deprecated CAS: 25052-55-5, 25854-33-5
EC number
200-830-5
Molecular formula
C2H5Cl
UNII
46U771ERWK
MDL number
MFCD00000961
InChIKey
HRYZWHHZPQKTII-UHFFFAOYSA-N
InChI
InChI=1S/C2H5Cl/c1-2-3/h2H2,1H3
SMILES (canonical and isomeric)
CCCl

Synonyms

  • Ethyl chloride
  • Ethane, chloro-
  • Chelen
  • Monochloroethane
  • Anodynon
  • Chlorene
  • Ether muriatic
  • Muriatic ether
  • Aethylis chloridum
  • Chlorethyl
  • Chloryl anesthetic
  • Cloretilo
  • Dublofix
  • Ether hydrochloric
  • Hydrochloric ether
  • Narcotile
  • Kelene
  • Ether chloratus
  • Monochlorethane
  • Aethylis
  • Aethylchlorid
  • Chloorethaan
  • Chloroaethan
  • Cloroetano
  • Ether chloridum
Show all 36 synonyms
  • Etylu chlorek
  • Cloruro di etile
  • Chlorure D'ethyle
  • Aethylchloride
  • mono-chloroethane
  • Ethyl chloride (USP)
  • Chloride, Ethyl
  • EtCl
  • Chemirosa, Cloretilo
  • Gebauer Ethyl Chloride
  • Gebauers Ethyl Chloride

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless liquidexp.
Odour
Ethereal odorexp.
Taste
Burning tasteexp.
Melting point
-138.7 °Cexp.
Boiling point
12.3 °Cexp.
Density
Relative density (water = 1): 0.918exp.
Flash point
-50 °Cexp.
Autoignition temperature
519 °Cexp.
Solubility
0.574 g/100 ml in water @ 20 °Cexp.
Vapour pressure
1010 mm Hg at 20 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
64.52 g/molcalc.
Exact mass
64.008 Dacalc.
LogP (octanol/water)
1.25calc.
Topological polar surface area
0 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
0calc.
Rotatable bonds
0calc.
Heavy atoms
3calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS02: Flammable
Flammable
GHS04: Gas under pressure
Gas under pressure
GHS08: Serious health hazard
Serious health hazard
410NFPA 704 rating

Hazard statements

  • H220Extremely flammable gas.
  • H351Suspected of causing cancer.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (11)
  • P203Obtain, read and follow all safety instructions before use.
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P222Do not allow contact with air.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P318If exposed or concerned, get medical advice.
  • P377Leaking gas fire: do not extinguish, unless leak can be stopped safely.
  • P381In case of leakage, eliminate all ignition sources.
  • P403Store in a well-ventilated place.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 1037
Transport hazard class
2.1

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Chloroethane suppliers

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All 38 suppliers
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Where suppliers are based

38 suppliers in 11 countries

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Chloroethane price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Chemical intermediate.

Refrigerant, solvent, alkylating agent, starting point in the mfr of tetraethyl lead, topical anesthetic.

Veterinary medication:.

Ethyl chloride is used in the production of ethyl cellulose, use as a solvent, refrigerant, and topical anesthetic, in the manufacture of dyes, chemicals, and pharmaceuticals, and as a medication to alleviate pain associated with insect burns and stings.

Industrial uses: Intermediate.

Use classes: Volatile organic compounds.

Industries and functions

Pharmacological actions

  • Anesthetics, Local

Roles

  • anaesthetic
  • antipruritic drug
  • dermatologic drug
  • general anaesthetic
  • inhalation anaesthetic
  • local anaesthetic
  • pharmaceutical

How it is made

Prepared by the action of chlorine on ethylene in the presence of hydrochloric acid and light, by action of chlorine on ethylene in presence of chlorides of copper, iron, antimony, and calcium, by heating alcohol, hydrochloric acid and zinc chloride.

Thermal chlorination of ethane.

By-product of vinyl chloride production or direct reduction of vinyl chloride, hydrochlorination of ethylene.

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 602-009-00-0

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Chloroethane, Ref no: 96, Annex ref: II/96

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Chloroethane is traded under.

HS 2903.11Exact HS code

Chloromethane (methyl chloride) and chloroethane (ethyl chloride)

World exports in 2024
$95.8M
+7.6% vs 2023, imports $91.4M
2019 to 2024
Top exporters
  1. Germany84.0%
  2. China5.0%
  3. United States4.0%
Top importers
  1. United States21.5%
  2. France * partner reported19.1%
  3. United Kingdom17.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Chloroethane is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Chloroethane, based on the data on this page

What is Chloroethane?

Chloroethane is the simplest and least toxic member of the class of chloroethanes, that is ethane in which a single hydrogen is substituted by a chlorine.

What is the CAS number of Chloroethane?

The CAS registry number of Chloroethane is 75-00-3. Other or deprecated CAS numbers: 25052-55-5, 25854-33-5.

What is the molecular formula and weight of Chloroethane?

The molecular formula of Chloroethane is C2H5Cl and its molar mass is 64.52 g/mol.

What is Chloroethane used for?

Chemical intermediate. Refrigerant, solvent, alkylating agent, starting point in the mfr of tetraethyl lead, topical anesthetic. Veterinary medication:.

Is Chloroethane hazardous?

Chloroethane carries the GHS signal word "Danger". Main hazards: extremely flammable gas, suspected of causing cancer, harmful to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Chloroethane?

Chloroethane is usually classified under HS code 290311 (Chloromethane (methyl chloride) and chloroethane (ethyl chloride)). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Chloroethane?

CompoundList lists 38 suppliers of Chloroethane in China, United States, India, Germany and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Chloroethane in India?

7 suppliers in India list Chloroethane on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Chloroethane?

Suppliers quote Chloroethane on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Chloroethane

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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