Chloroxine
Also known as 5,7-Dichloroquinolin-8-ol, 5,7-Dichloro-8-hydroxyquinoline, 5,7-Dichloro-8-quinolinol
Key facts
What buyers check first
- CAS number
- 773-76-2
- Formula
- C9H5Cl2NO
- Molar mass
- 214.05 g/mol
- EC number
- 212-258-3
- HS code
- 293349
- Category
- Antibiotics and anti-infectives
What is Chloroxine?
Plain description, key identifiers and synonyms
Chloroxine is a monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 have been substituted by chlorine. A synthetic antibacterial prepared by chlorination of quinolin-8-ol, it is used for the treatment of dandruff and seborrhoeic dermatitis of the scalp. It has a role as an antibacterial agent, an antiseborrheic and an antifungal drug. It is an organochlorine compound and a monohydroxyquinoline. It is functionally related to a quinolin-8-ol.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- 5,7-dichloroquinolin-8-ol
- CAS number
- 773-76-2 CAS number cross-checked
- EC number
- 212-258-3
- Molecular formula
- C9H5Cl2NO
- UNII
- 2I8BD50I8B
- MDL number
- MFCD00006786
- InChIKey
- WDFKMLRRRCGAKS-UHFFFAOYSA-N
- InChI
- InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
- SMILES (canonical and isomeric)
- C1=CC2=C(C(=C(C=C2Cl)Cl)O)N=C1
Synonyms
- 5,7-Dichloroquinolin-8-ol
- 5,7-Dichloro-8-hydroxyquinoline
- 5,7-Dichloro-8-quinolinol
- Chlorquinol
- Capitrol
- Quixalin
- Dichlorohydroxyquinoline
- 5,7-Dichlorooxine
- 5,7-Dichloroxine
- 8-Quinolinol, 5,7-dichloro-
- 5,7-Dichloro-8-oxyquinoline
- 5,7-Dichlor-8-hydroxychinolin
- dichloroquine
- Dichloroxin
- Chloroxyquinoline
- Dichloroquinolinol
- Clofuzid
- Endiaron
- Chlofucid
- Dikhloroskin
- Quesyl
- Chlorohydroxyquinoline
- CHQ
- 5,7-Dichloro-8-hydroquinoline
- Chloroxine (USAN)
Show all 33 synonymsShow fewer synonyms
- Clioquinol EP Impurity B
- Capitrol Cream Shampoo
- 5,7-Dichloro-8-oxine
- SQ 16401
- 5,7-Dichloroquinolin-8-ol, Clioquinol Imp. B (EP), Clioquinol Impurity B
- Capitrol (TN)
- Clioquinol Impurity 6
- 8-Quinolinol,7-dichloro-
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 214.05 g/molcalc.Computed value |
|---|---|
| Exact mass | 212.9748 Dacalc.Computed value |
| LogP (octanol/water) | 3.25calc.Computed value |
| Topological polar surface area | 33.12 ร
ยฒcalc.Computed value |
| Hydrogen bond donors | 1calc.Computed value |
| Hydrogen bond acceptors | 2calc.Computed value |
| Rotatable bonds | 0calc.Computed value |
| Heavy atoms | 13calc.Computed value |
| Rings | 2calc.Computed value |
| Aromatic rings | 2calc.Computed value |
| Fraction sp3 carbons | 0calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 0calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
c1ccc2ncccc2c1
2 rings, 10 atoms, the Quinoline ring system.
21,766 other chemicals share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H302Harmful if swallowed.
- H315Causes skin irritation.
- H318Causes serious eye damage.
- H335May cause respiratory irritation.
Precautionary statements (19)
- P261Avoid breathing dust, fume, gas, mist, vapours or spray.
- P264Wash skin thoroughly after handling.
- P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
- P270Do not eat, drink or smoke when using this product.
- P271Use only outdoors or in a well-ventilated area.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P301 + P317If swallowed: Get medical help.
- P302 + P352If on skin: Wash with plenty of water.
- P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
- P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P317Get medical help.
- P319Get medical help if you feel unwell.
- P321Specific treatment (see supplemental first aid instructions on the label).
- P330Rinse mouth.
- P332 + P317If skin irritation occurs: Get medical help.
- P362 + P364Take off contaminated clothing. And wash it before reuse.
- P403 + P233Store in a well-ventilated place. Keep container tightly closed.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidChloroxine suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- China ManufacturerUnclaimed profileChloroxineGrade, purity and minimum order on requestPrice on request
- China, KowloonUnclaimed profileChloroxineGrade, purity and minimum order on requestPrice on request
- United States, HauppaugeUnclaimed profileChloroxineGrade, purity and minimum order on requestPrice on request
- Price on request
- Price on request
- United States, Wood DaleUnclaimed profileChloroxineGrade, purity and minimum order on requestPrice on request
- China, ShanghaiUnclaimed profileChloroxineGrade, purity and minimum order on requestPrice on request
- Price on request
- Price on request
- Canada, Niagara-on-the-LakeUnclaimed profileChloroxineGrade, purity and minimum order on requestPrice on request
Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.
Where suppliers are based
15 suppliers in 6 countries
Send one request to many suppliers
Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.
Chloroxine price
Indicative price range per kg from live supplier offers
Suppliers quote this chemical on request. Send one free request and compare quotes side by side.
Uses and applications
What the substance is used for, by industry and function
Industries and functions
Pharmacological actions
- Anti-Bacterial Agents
- Antifungal Agents
Roles
- antibacterial agent
- antifungal agent
- antifungal drug
- antiinfective agent
- antimicrobial agent
- antiseborrheic
- dermatologic drug
- pharmaceutical
Pharmacology
Chloroxine is a synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of chloroxine diminishes mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp, including psoriasis and eczema.
Regulatory status
Inventories, regulations and trade controls that list this substance
United States
- TSCA inventory (USA)Status: Active in US commerce
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Chloroxine is traded under.
Compounds containing in the structure a quinoline or isoquinoline ring-system (whetherโฆ
- China30.1%
- India * partner reported16.7%
- Switzerland * partner reported14.1%
- United Kingdom19.2%
- Germany16.0%
- Romania8.3%
* Partner reported figures, a lower bound.
The HS code shown for Chloroxine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Frequently asked questions
Quick answers about Chloroxine, based on the data on this page
What is Chloroxine?
What is the CAS number of Chloroxine?
What is the molecular formula and weight of Chloroxine?
What is Chloroxine used for?
Is Chloroxine hazardous?
What is the HS code of Chloroxine?
Where can I buy Chloroxine?
What is the price of Chloroxine?
Guides for buyers
Practical guides that help when you source, ship or handle Chloroxine
- Article, QualityPharma grades explained: IP vs BP vs USP vs EPWhat the Indian, British, US and European pharmacopoeias are, how their monographs differ, what multi grade claims mean and why a grade alone does not make a product fit for medicines.Read
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
Get quotes for Chloroxine
Embed this structure on your websiteShow code
Paste this code into your page to show the 2D structure of Chloroxine with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.
<iframe src="https://www.compoundlist.com/embed/structure/chloroxine-773-76-2" title="Chloroxine structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>Explore more in Antibiotics and anti-infectives or HS code 293349