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Respiratory, allergy and digestive drugs

(±)-Chlorpheniramine

Also known as chlorpheniramine, Chlorphenamine, Chlorophenylpyridamine

CAS 132-22-9Formula C16H19ClN2Molar mass 274.80 g/molEC 205-054-0
32 suppliers listed Drug substance
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(±)-Chlorpheniramine chemical structure, C16H19ClN2, CAS 132-22-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Oily liquid
Boiling point
142 °C
Solubility
UV max absorption (water): 261 nm (E=5760), Solubility in mg/ml at 25 °C: Ethanol 330, c…
HS code
293339
Category
Respiratory, allergy and digestive drugs
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is (±)-Chlorpheniramine?

Plain description, key identifiers and synonyms

Chlorphenamine is a tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma. It has a role as an antidepressant, a H1-receptor antagonist, a histamine antagonist, an anti-allergic agent, a serotonin uptake inhibitor and an antipruritic drug. It is a member of pyridines, a tertiary amino compound and a member of monochlorobenzenes.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
CAS number
132-22-9 CAS number cross-checkedOther or deprecated CAS: 113-92-8
EC number
205-054-0
Molecular formula
C16H19ClN2
UNII
3U6IO1965U
MDL number
MFCD00053581
InChIKey
SOYKEARSMXGVTM-UHFFFAOYSA-N
InChI
InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
SMILES (canonical and isomeric)
CN(C)CCC(C1=CC=C(C=C1)Cl)C2=CC=CC=N2

Synonyms

  • chlorpheniramine
  • Chlorphenamine
  • Chlorophenylpyridamine
  • Haynon
  • Clorfeniramina
  • Allergican
  • Allergisan
  • Clorfenamina
  • Histadur
  • Chloropheniramine
  • Chlorprophenpyridamine
  • Chloroprophenpyridamine
  • Chlorpheniraminum
  • Chlorphenaminum
  • 4-Chloropheniramine
  • Clofeniramina
  • 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
  • Chlorphenamin
  • 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
  • 3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
  • gamma-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine
  • gamma-(4-Chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine
  • 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine
  • (+-)-Chlorpheniramine
  • 3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine
Show all 39 synonyms
  • 2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine
  • Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-
  • Hayon
  • Tuzistra componenet of chlorpheniramine
  • 2-[p-chloro-alpha-[2-(dimethylamino)ethyl]benzyl]pyridine
  • (3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl)dimethylamine
  • [3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine
  • Cloro-Trimeton
  • Tannate, Chlorpheniramine
  • Chloropheniramine-d4
  • Teldrin
  • Polaronil
  • 3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine
  • Chlorpheniramine polistirex

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Oily liquidexp.
Boiling point
142 °Cexp.
Solubility
UV max absorption (water): 261 nm (E=5760), Solubility in mg/ml at 25 °C: Ethanol 330, chloroform 240, water 160, methanol 130, pH of a 2% aqueous solution about 5 /Maleate/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
274.80 g/molcalc.
Exact mass
274.1237 Dacalc.
LogP (octanol/water)
3.82calc.
Topological polar surface area
16.13 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
5calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.31calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Cc2ccccn2)cc1

c1ccc(Cc2ccccn2)cc1

2 rings, 13 atoms, the 2-(Phenylmethyl)pyridine ring system.

671 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

(±)-Chlorpheniramine suppliers

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All 32 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

32 suppliers in 12 countries

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(±)-Chlorpheniramine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Allergic Agents
  • Antipruritics
  • Histamine H1 Antagonists

Roles

  • H1-receptor antagonist
  • antagonist
  • anti-allergic agent
  • antidepressant
  • antipruritic drug
  • central nervous system drug
  • dermatologic drug
  • histamine antagonist
  • histaminergic drug
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • serotonergic drug
  • serotonin uptake inhibitor

Pharmacology

Chlorpheniramine is a Histamine-1 Receptor Antagonist. The mechanism of action of chlorpheniramine is as a Histamine H1 Receptor Antagonist.

How it is made

Condensation of 2-(p-chloro-alpha-(2-chloroethyl)benzyl)pyridine with dimethylamine in the presence of sodamide

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (±)-Chlorpheniramine is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (±)-Chlorpheniramine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (±)-Chlorpheniramine, based on the data on this page

What is (±)-Chlorpheniramine?

Chlorphenamine is a tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups.

What is the CAS number of (±)-Chlorpheniramine?

The CAS registry number of (±)-Chlorpheniramine is 132-22-9. Other or deprecated CAS numbers: 113-92-8.

What is the molecular formula and weight of (±)-Chlorpheniramine?

The molecular formula of (±)-Chlorpheniramine is C16H19ClN2 and its molar mass is 274.80 g/mol.

What is (±)-Chlorpheniramine used for?

Veterinary medication:. Use classes: Pharmaceuticals.

Is (±)-Chlorpheniramine hazardous?

No GHS hazard classification for (±)-Chlorpheniramine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of (±)-Chlorpheniramine?

(±)-Chlorpheniramine is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (±)-Chlorpheniramine?

CompoundList lists 32 suppliers of (±)-Chlorpheniramine in United States, China, Hong Kong, Canada and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy (±)-Chlorpheniramine in India?

2 suppliers in India list (±)-Chlorpheniramine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of (±)-Chlorpheniramine?

Suppliers quote (±)-Chlorpheniramine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (±)-Chlorpheniramine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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