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Respiratory, allergy and digestive drugs

Brompheniramine

Also known as Parabromdylamine, Bromfeniramina, Brompheniraminum

CAS 86-22-6Formula C16H19BrN2Molar mass 319.25 g/molEC 201-657-8
GHS signal word: Warning. Pictograms: Harmful or irritant 43 suppliers listed Drug substance
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Brompheniramine chemical structure, C16H19BrN2, CAS 86-22-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Oily liquid with slightly yellow color
Melting point
132 to 134
Boiling point
150 °C
Solubility
ODORLESS, WHITE, CRYSTALLINE POWDER, 1 G SOL IN ABOUT 15 ML CHLOROFORM, ABOUT 5 ML WATER…
HS code
293339
Category
Respiratory, allergy and digestive drugs
Illustrative photo, golden oily liquid in a glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Brompheniramine?

Plain description, key identifiers and synonyms

Brompheniramine is pheniramine in which the hydrogen at position 4 of the phenyl substituent is substituted by bromine. A histamine H1 receptor antagonist, brompheniramine is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis. It has a role as a H1-receptor antagonist and an anti-allergic agent. It is a member of pyridines and an organobromine compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
CAS number
86-22-6 CAS number cross-checkedOther or deprecated CAS: 156428-33-0
EC number
201-657-8
Molecular formula
C16H19BrN2
UNII
H57G17P2FN
MDL number
MFCD00865691
InChIKey
ZDIGNSYAACHWNL-UHFFFAOYSA-N
InChI
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
SMILES (canonical and isomeric)
CN(C)CCC(C1=CC=C(C=C1)Br)C2=CC=CC=N2

Synonyms

  • Parabromdylamine
  • Bromfeniramina
  • Brompheniraminum
  • Bromfed
  • 3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
  • Bromfenex
  • Brotane
  • 1-(p-Bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
  • 3-(p-Bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
  • 2-(p-Bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine
  • Dimetapp Allergy
  • 3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine
  • gamma-(4-Bromophenyl)-N,N-dimethyl-2-pyridinepropanamine
  • 2-Pyridinepropanamine, gamma-(4-bromophenyl)-N,N-dimethyl-
  • Pyridine, 2-(p-bromo-alpha-(2-(dimethylamino)ethyl)benzyl)-
  • [3-(4-bromophenyl)-3-(pyridin-2-yl)propyl]dimethylamine
  • p-Bromdylamine
  • para-Bromdylamine
  • [3-(4-Bromo-phenyl)-3-pyridin-2-yl-propyl]-dimethyl-amine
  • (3-(4-bromophenyl)-3-(pyridin-2-yl)propyl)dimethylamine
  • (3-(4-Bromo-phenyl)-3-pyridin-2-yl-propyl)-dimethyl-amine
  • p Bromdylamine
  • Dimetane Ten
  • para Bromdylamine
  • Oraminic 2
Show all 34 synonyms
  • (+-)-Brompheniramine
  • Parabromodylamine
  • Antihistamine compound
  • 3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine
  • Brompheniramine (INN)
  • Lodrane
  • Dimetane-ten
  • 3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine
  • Bromopheniramine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Oily liquid with slightly yellow colorexp.
Odour
Characteristic amine-likeexp.
Melting point
132 to 134exp.
Boiling point
150 °Cexp.
Solubility
ODORLESS, WHITE, CRYSTALLINE POWDER, 1 G SOL IN ABOUT 15 ML CHLOROFORM, ABOUT 5 ML WATER, ABOUT 15 ML ALC /MALEATE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
319.25 g/molcalc.
Exact mass
318.0732 Dacalc.
LogP (octanol/water)
3.93calc.
Topological polar surface area
16.13 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
5calc.
Heavy atoms
19calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.31calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(Cc2ccccn2)cc1

c1ccc(Cc2ccccn2)cc1

2 rings, 13 atoms, the 2-(Phenylmethyl)pyridine ring system.

671 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Brompheniramine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 43 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

43 suppliers in 12 countries

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Brompheniramine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

For the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.

Veterinary medication:.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Allergic Agents
  • Histamine H1 Antagonists

Roles

  • H1-receptor antagonist
  • antagonist
  • anti-allergic agent
  • histamine antagonist
  • histaminergic drug
  • neurotransmitter agent
  • pharmaceutical

How it is made

Reaction of alpha-(p-bromophenyl)-2-pyridine-acetonitrile with sodamide followed by condensation with 2-chloro-n,n-dimethylethylamine, conversion to the corresponding acid, and decarboxylation by treatment with sulfuric acid

Alpha-(p-bromophenyl)-2-pyridine-acetonitrile is converted to its sodium deriv.../which/ is...condensed with 2-chloro-n,n-dimethylethylamine. Resulting nitrile...converted to its corresponding acid.../&/ decarboxylated... Mixt (made) alkaline, brompheniramine base...extracted & reacted with...maleic acid. (Maleate)

Preparation from alpha-(p-bromophenyl)-alpha-(beta-dimethylaminoethyl)-2-pyridylacetonitrile: Sperber et al., US 2567245 (1951), US 2676964 (1954 to Schering).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Brompheniramine (INN) and its salts, Ref no: 59, Annex ref: II/59
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Inactive in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Brompheniramine is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Brompheniramine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Brompheniramine, based on the data on this page

What is Brompheniramine?

Brompheniramine is pheniramine in which the hydrogen at position 4 of the phenyl substituent is substituted by bromine. A histamine H1 receptor antagonist, brompheniramine is used (commonly as its maleate salt) for the symptomatic relief of allergic conditions, including rhinitis and conjunctivitis.

What is the CAS number of Brompheniramine?

The CAS registry number of Brompheniramine is 86-22-6. Other or deprecated CAS numbers: 156428-33-0.

What is the molecular formula and weight of Brompheniramine?

The molecular formula of Brompheniramine is C16H19BrN2 and its molar mass is 319.25 g/mol.

What is Brompheniramine used for?

For the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. Veterinary medication:. Use classes: Pharmaceuticals.

Is Brompheniramine hazardous?

Brompheniramine carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Brompheniramine?

Brompheniramine is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Brompheniramine?

CompoundList lists 43 suppliers of Brompheniramine in United States, China, Hong Kong, United Kingdom and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Brompheniramine in India?

2 suppliers in India list Brompheniramine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Brompheniramine?

Suppliers quote Brompheniramine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Brompheniramine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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