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Impurities and reference standards

Chlorprothixene, (E)-

Also known as (E)-chlorprothixene, (3E)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine, Chlorprothixene EP Impurity F

CAS 4546-35-4Formula C18H18ClNSMolar mass 315.87 g/mol
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Chlorprothixene, (E)- chemical structure, C18H18ClNS, CAS 4546-35-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
4546-35-4
Formula
C18H18ClNS
Molar mass
315.87 g/mol
HS code
293499
Category
Impurities and reference standards

What is Chlorprothixene, (E)-?

Plain description, key identifiers and synonyms

Chlorprothixene is an organochlorine compound, a member of thioxanthenes and a tertiary amino compound. It has a role as a non-narcotic analgesic, a sedative, a dopaminergic antagonist, a cholinergic antagonist, an antiemetic and a first generation antipsychotic. It is a conjugate base of a chlorprothixene(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3E)-3-(2-chlorothioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine
CAS number
4546-35-4Other or deprecated CAS: 2461-06-5
Molecular formula
C18H18ClNS
UNII
73V29V2M54
InChIKey
WSPOMRSOLSGNFJ-VGOFMYFVSA-N
InChI
InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3/b14-7+
Canonical SMILES
CN(C)CCC=C1c2ccccc2Sc2ccc(Cl)cc21
Isomeric SMILES
CN(C)CC/C=C/1\C2=CC=CC=C2SC3=C1C=C(C=C3)Cl

Synonyms

  • (E)-chlorprothixene
  • (3E)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine
  • Chlorprothixene EP Impurity F
  • Tactaran
  • 1-Propanamine, 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-, (3E)-
  • alpha-Chlorprothixene
  • trans-Chloroprothixene
  • Chlorprothixene (cis)
  • trans(E)-Chlorprothixen
  • 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine
  • (E)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine
  • (Z)-3-(2-Chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine
  • (3E)-3-(2-chlorothioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine
  • {3-[(9E)-2-chloro-9H-thioxanthen-9-ylidene]propyl}dimethylamine
  • 9H-Thioxanthene, 1-propanamine deriv.
  • Ro-4-04033
  • Chlorprothixene Hydrochloride Impurity F [Ep Impurity]
  • 2-Chloro-9-(3-dimethylaminopropylidene)thioxanthene
  • 2-Chloro-9-(3-(dimethylamino)propylidene)thioxanthene, (Z)-
  • (Z)-2-Chloro-N,N-dimethylthioxanthene-delta9,gamma-propylamine
  • 2-Chloro-N,N-dimethylthioxanthene-delta9,gamma-propylamine
  • Thioxanthene-delta9, gamma-propylamine, 2-chloro-N,N-dimethyl-
  • (3E)-3-(2-Chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine
  • (3E)-3-(2-chlorothioxanthen-9-ylidene)-N,N-dimethyl-propan-1-amine
  • (3Z)-3-(2-Chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-1-propanamine #
Show all 28 synonyms
  • (Z)-2-Chloro-N,N-dimethylthioxanthene-(delta9,gamma)-propylamine
  • 1-Propanamine, 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-
  • Thioxanthene-delta9,gamma-propylamine, 2-chloro-N,N-dimethyl-, (Z)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
315.87 g/molcalc.
Exact mass
315.0848 Dacalc.
LogP (octanol/water)
5.19calc.
Topological polar surface area
3.24 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
21calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.22calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C=C1c2ccccc2Sc2ccccc21

C=C1c2ccccc2Sc2ccccc21

3 rings, 15 atoms, the 9-Methylenethioxanthene ring system.

85 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Chlorprothixene, (E)- suppliers

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Chlorprothixene, (E)- price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Roles

  • analgesic
  • antagonist
  • antiemetic
  • antipsychotic agent
  • central nervous system depressant
  • central nervous system drug
  • cholinergic antagonist
  • cholinergic drug
  • dopaminergic agent
  • dopaminergic antagonist
  • first generation antipsychotic
  • neurotransmitter agent
  • non-narcotic analgesic
  • pharmaceutical
  • psychotropic drug
  • sedative
  • tranquilizing drug

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Chlorprothixene, (E)- is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Chlorprothixene, (E)- is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Chlorprothixene, (E)-, based on the data on this page

What is Chlorprothixene, (E)-?

Chlorprothixene is an organochlorine compound, a member of thioxanthenes and a tertiary amino compound. It has a role as a non-narcotic analgesic, a sedative, a dopaminergic antagonist, a cholinergic antagonist, an antiemetic and a first generation antipsychotic. It is a conjugate base of a chlorprothixene(1+).

What is the CAS number of Chlorprothixene, (E)-?

The CAS registry number of Chlorprothixene, (E)- is 4546-35-4. Other or deprecated CAS numbers: 2461-06-5.

What is the molecular formula and weight of Chlorprothixene, (E)-?

The molecular formula of Chlorprothixene, (E)- is C18H18ClNS and its molar mass is 315.87 g/mol.

What is Chlorprothixene, (E)- used for?

Use classes: Pharmaceuticals.

Is Chlorprothixene, (E)- hazardous?

No GHS hazard classification for Chlorprothixene, (E)- is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Chlorprothixene, (E)-?

Chlorprothixene, (E)- is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Chlorprothixene, (E)-?

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What is the price of Chlorprothixene, (E)-?

Suppliers quote Chlorprothixene, (E)- on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Chlorprothixene, (E)-

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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