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Clindamycin

Also known as Chlolincocin, Clindamicina, Clinimycin

Clindamycin chemical structure, C18H33ClN2O5S, CAS 18323-44-9
2D chemical structure

Key facts

What buyers check first

CAS number
18323-44-9
Formula
C18H33ClN2O5S
Molar mass
424.99 g/mol
Appearance
Yellow, amorphous solid
HS code
294190
Category
Antibiotics and anti-infectives
Illustrative photo, yellow pigment powder in a glass jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Clindamycin?

Plain description, key identifiers and synonyms

Clindamycin is a semisynthetic broad spectrum antibiotic produced by chemical modification of the parent compound lincomycin. Clindamycin dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. (NCI04)

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide
CAS number
18323-44-9 CAS number cross-checked
EC number
242-209-1
Molecular formula
C18H33ClN2O5S
UNII
3U02EL437C
MDL number
MFCD00072005
InChIKey
KDLRVYVGXIQJDK-AWPVFWJPSA-N
InChI
InChI=1S/C18H33ClN2O5S/c1-5-6-10-7-11(21(3)8-10)17(25)20-12(9(2)19)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,22-24H,5-8H2,1-4H3,(H,20,25)/t9-,10+,11-,12+,13-,14+,15+,16+,18+/m0/s1
Canonical SMILES
CCCC1CC(C(=O)NC(C(C)Cl)C2OC(SC)C(O)C(O)C2O)N(C)C1
Isomeric SMILES
CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl

Synonyms

  • Chlolincocin
  • Clindamicina
  • Clinimycin
  • Clindamycine
  • 7-Chlorolincomycin
  • 7(S)-Chloro-7-deoxylincomycin
  • Clindamycinum
  • 7-Chloro-7-deoxylincomycin
  • 7-Deoxy-7(S)-chlorolincomycin
  • Clindamycin In 5 Percent Dextrose
  • (2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide
  • L-threo-alpha-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-((((2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-
  • L-threo-alpha-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(((1-methyl-4-propyl-2-pyrrolidinyl)carbonyl)amino)-1-thio-, (2S-trans)-
  • L-threo-D-galacto-Octopyranoside, methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-, trans-alpha-
  • Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside
  • Chlorlincocin
  • (2S,4R)-N-((1S,2S)-2-chloro-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide
  • ClindaMed Oral Drops
  • clindamycini hydrochloridum
  • 7 Chloro 7 deoxylincomycin
  • Monohydrochloride, Clindamycin
  • Clindamycin in percent Dextrose
  • (2S,4R)-N-(2-chloro-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide
  • Monohydrate Clindamycin Monohydrochloride
  • Monohydrochloride, Monohydrate Clindamycin
Show all 35 synonyms
  • Clindamax
  • Dalacine
  • Dalacin C
  • Sobelin
  • Clindamycin (USAN/INN)
  • (2S,4R)-N-((1S,2S)-2-chloro-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide
  • Cleocin
  • Klimicin
  • ClindaDerm
  • Klindan 300

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Yellow, amorphous solidexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
424.99 g/molcalc.
Exact mass
424.1799 Dacalc.
LogP (octanol/water)
0.39calc.
Topological polar surface area
102.3 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
7calc.
Heavy atoms
27calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.94calc.
Formal charge
0calc.
Stereocentres
9calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(NCC1CCCCO1)C1CCCN1

O=C(NCC1CCCCO1)C1CCCN1

2 rings, 15 atoms.

138 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H319Causes serious eye irritation.
  • H362May cause harm to breast-fed children.
Precautionary statements (19)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Clindamycin suppliers

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Clindamycin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Semi-synthetic antibiotic prepared from lincomycin.

Clindamycin has found use in the treatment of common infections caused by gram-positive cocci.

It is used as an orally-active lincomycin-group antibiotic with the same range of activity as lincomycin.

Veterinary medication:.

Use classes: Pharmaceuticals, Animal Drugs.

Pharmacological actions

  • Anti-Bacterial Agents
  • Protein Synthesis Inhibitors

Roles

  • environmental contaminant
  • xenobiotic

Pharmacology

Clindamycin is a Lincosamide Antibacterial. The physiologic effect of clindamycin is by means of Decreased Sebaceous Gland Activity and Neuromuscular Blockade.

How it is made

Lincomycin is treated with a solution of Rydon reagent prepared from triphenylphosphine, acetonitrile, and chlorine. The base is ultimately reacted with hydrochloric acid.

First resulted from the reaction of lincomycin and thionyl chloride, improved synthetic methods involve the reaction of lincomycin and triphenylphosphine dichloride or triphenylphosphine in carbon tetrachloride.

Synthesized ... by introducing a chlorine atom at the 7 position of lincomycin.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Clindamycin is traded under.

HS 2941.90Indicative HS code

Antibiotics, other

World exports in 2024
$6.39B
+2.3% vs 2023, imports $6.97B
2019 to 2024
Top exporters
  1. China39.7%
  2. United States11.3%
  3. Switzerland * partner reported10.9%
Top importers
  1. Italy15.0%
  2. India * partner reported12.0%
  3. China8.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Clindamycin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Clindamycin, based on the data on this page

What is Clindamycin?

Clindamycin is a semisynthetic broad spectrum antibiotic produced by chemical modification of the parent compound lincomycin. Clindamycin dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. (NCI04)

What is the CAS number of Clindamycin?

The CAS registry number of Clindamycin is 18323-44-9.

What is the molecular formula and weight of Clindamycin?

The molecular formula of Clindamycin is C18H33ClN2O5S and its molar mass is 424.99 g/mol.

What is Clindamycin used for?

Semi-synthetic antibiotic prepared from lincomycin. Clindamycin has found use in the treatment of common infections caused by gram-positive cocci. It is used as an orally-active lincomycin-group antibiotic with the same range of activity as lincomycin. Veterinary medication:. Use classes: Pharmaceuticals, Animal Drugs.

Is Clindamycin hazardous?

Clindamycin carries the GHS signal word "Warning". Main hazards: harmful if swallowed, may cause an allergic skin reaction, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Clindamycin?

Clindamycin is usually classified under HS code 294190 (Antibiotics, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Clindamycin?

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Where can I buy Clindamycin in India?

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What is the price of Clindamycin?

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Guides for buyers

Practical guides that help when you source, ship or handle Clindamycin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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