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Analgesics and anti-inflammatories

Clocortolone

Also known as Clocortolona, Clocortolonum, 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methyl-1,4-pregnadien-3,20-dione

CAS 4828-27-7Formula C22H28ClFO4Molar mass 410.91 g/molEC 225-406-7
1 supplier listed Drug substance
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Clocortolone chemical structure, C22H28ClFO4, CAS 4828-27-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
4828-27-7
Formula
C22H28ClFO4
Molar mass
410.91 g/mol
EC number
225-406-7
HS code
293722
Category
Analgesics and anti-inflammatories

What is Clocortolone?

Plain description, key identifiers and synonyms

Clocortolone is 16alpha-Methylpregna-1,4-diene-3,20-dione bearing hydroxy substituents at the 11beta and 21 positions, fluorine at position 6 and chlorine at position 9. A medium potency corticosteroid, it is used as its 21-O-pivalate or caproate ester for the relief of inflammatory and pruritic (itching) skin disorders. It has a role as an anti-inflammatory drug and an antipruritic drug. It is a primary alpha-hydroxy ketone, a glucocorticoid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a chlorinated steroid.

Clocortolone is a pharmaceutical drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6S,8S,9R,10S,11S,13S,14S,16R,17S)-9-chloro-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
CAS number
4828-27-7Other or deprecated CAS: 34097-16-0
EC number
225-406-7
Molecular formula
C22H28ClFO4
UNII
N8ZUB7XE0H
InChIKey
YMTMADLUXIRMGX-RFPWEZLHSA-N
InChI
InChI=1S/C22H28ClFO4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-21(15,3)22(14,23)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,18+,19-,20+,21+,22+/m1/s1
Canonical SMILES
CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(Cl)C(O)CC2(C)C1C(=O)CO
Isomeric SMILES
C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)O)Cl)C)F

Synonyms

  • Clocortolona
  • Clocortolonum
  • 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methyl-1,4-pregnadien-3,20-dione
  • 9-chloro-6alpha-fluoro-16alpha-methyl-1,4-pregnadiene-11beta,21-diol-3,20-dione
  • 9-chloro-6 alpha-fluoro-11 beta,21-dihydroxy-16 alpha-methylpregnadiene-3,20-dione 21-acetate
  • Clocortolone (INN)
  • Clorcortelone
  • 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
  • Clocortolon
  • 9-Chlor-6alpha-fluor-11beta,21-dihydroxy-16alpha-methyl-1,4-pregnadien-3,20-dion
  • Clocortolone Solution in Acetonitrile, 100ug/mL
  • (6a,11b,16a)-9-Chloro-6-fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • 9-Chloro-6a-fluoro-11b,21-dihydroxy-16a-methylpr egna-1,4-diene-3,20-dione
  • 9-Chloro-6a-fluoro-11b,21-dihydroxy-17a-methylpregna-1,4-diene-3,20-dione
  • 9-Chloro-6.aplha.-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
  • Pregna-1,4-diene-3,20-dione, 21-hydroxy-9-chloro-6-fluoro-11-hydroxy-16-methyl-, (6alpha,11beta,16.alpha.)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
410.91 g/molcalc.
Exact mass
410.166 Dacalc.
LogP (octanol/water)
3calc.
Topological polar surface area
74.6 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
28calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.73calc.
Formal charge
0calc.
Stereocentres
9calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

4 rings, 18 atoms.

956 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Clocortolone suppliers

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Where suppliers are based

1 supplier in 0 countries

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Clocortolone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Inflammatory Agents
  • Glucocorticoids

Roles

  • anti-inflammatory agent
  • anti-inflammatory drug
  • antipruritic drug
  • dermatologic drug
  • pharmaceutical

Pharmacology

Clocortolone is a Corticosteroid. The mechanism of action of clocortolone is as a Corticosteroid Hormone Receptor Agonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Clocortolone is traded under.

HS 2937.22Indicative HS code

Halogenated derivatives of corticosteroidal hormones

World exports in 2024
$1.65B
−29.3% vs 2023, imports $1.67B
2019 to 2024
Top exporters
  1. United Kingdom69.1%
  2. Italy7.8%
  3. Singapore5.6%
Top importers
  1. United States64.5%
  2. Spain5.1%
  3. United Kingdom3.7%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Clocortolone is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Clocortolone, based on the data on this page

What is Clocortolone?

Clocortolone is 16alpha-Methylpregna-1,4-diene-3,20-dione bearing hydroxy substituents at the 11beta and 21 positions, fluorine at position 6 and chlorine at position 9.

What is the CAS number of Clocortolone?

The CAS registry number of Clocortolone is 4828-27-7. Other or deprecated CAS numbers: 34097-16-0.

What is the molecular formula and weight of Clocortolone?

The molecular formula of Clocortolone is C22H28ClFO4 and its molar mass is 410.91 g/mol.

What is Clocortolone used for?

Known uses and roles of Clocortolone include anti-inflammatories in pharmaceuticals, hormones and steroids in pharmaceuticals, anti-inflammatory agent, anti-inflammatory drug, antipruritic drug and 4 more.

Is Clocortolone hazardous?

No GHS hazard classification for Clocortolone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Clocortolone?

Clocortolone is usually classified under HS code 293722 (Halogenated derivatives of corticosteroidal hormones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Clocortolone?

CompoundList lists 1 supplier of Clocortolone. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Clocortolone?

Suppliers quote Clocortolone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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