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Other active pharmaceutical ingredients

Clodronate

Also known as Clodronic Acid, (Dichloromethylene)diphosphonic acid, Acido clodronico

CAS 10596-23-3Formula CH4Cl2O6P2Molar mass 244.89 g/molEC 234-212-1
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Clodronate chemical structure, CH4Cl2O6P2, CAS 10596-23-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
10596-23-3
Formula
CH4Cl2O6P2
Molar mass
244.89 g/mol
EC number
234-212-1
HS code
293159
Category
Other active pharmaceutical ingredients

What is Clodronate?

Plain description, key identifiers and synonyms

Clodronic acid is an organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases. It has a role as an antineoplastic agent and a bone density conservation agent. It is an organochlorine compound, a one-carbon compound and a 1,1-bis(phosphonic acid). It is a conjugate acid of a clondronate(2-).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
[dichloro(phosphono)methyl]phosphonic acid
CAS number
10596-23-3 CAS number cross-checked
EC number
234-212-1
Molecular formula
CH4Cl2O6P2
UNII
0813BZ6866
MDL number
MFCD00867075
InChIKey
ACSIXWWBWUQEHA-UHFFFAOYSA-N
InChI
InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)
SMILES (canonical and isomeric)
C(P(=O)(O)O)(P(=O)(O)O)(Cl)Cl

Synonyms

  • Clodronic Acid
  • (Dichloromethylene)diphosphonic acid
  • Acido clodronico
  • Acide clodronique
  • [dichloro(phosphono)methyl]phosphonic acid
  • Acidum clodronicum
  • Clodronsaeure
  • Dichloromethylidene diphosphonate
  • (Dichloromethylene)bisphosphonic acid
  • Dichloromethanediphosphonic acid
  • Phosphonic acid, (dichloromethylene)bis-
  • Clasteon
  • Loron
  • (Dichloro-phosphono-methyl)-phosphonic acid
  • dichloromethylene-1,1-diphosphonic acid
  • dichloromethylene-1,1-bisphosphonic acid
  • Acid, Clodronic
  • Acid, Dichloromethanediphosphonic
  • (dichloro-phosphonomethyl)phosphonic acid
  • Cl2MDP
  • (dichloro(phosphono)methyl)phosphonic acid
  • Dichloromethanediphosphonate
  • Diphosphonate, Dichloromethane
  • Osphos
  • Dichloromethylene Biphosphonate
Show all 34 synonyms
  • Biphosphonate, Dichloromethylene
  • Diphosphonate, Dichloromethylene
  • (dichloromethylene)bis(phosphonic acid)
  • dichloromethylenediphosphonic acid
  • HSCI1_000244
  • Methanedichlorodiphosphonic acid
  • CH4Cl2O6P2
  • Dichlormethylen-bis(phosphonsaeure)
  • Methanedichlorodiphosphonate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
244.89 g/molcalc.
Exact mass
243.886 Dacalc.
LogP (octanol/water)
0.43calc.
Topological polar surface area
115.1 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
2calc.
Heavy atoms
11calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Clodronate suppliers

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All 44 suppliers
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Where suppliers are based

44 suppliers in 11 countries

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Clodronate price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Animal Drugs.

Pharmacological actions

  • Bone Density Conservation Agents

Roles

  • antineoplastic agent
  • bone density conservation agent
  • pharmaceutical

Pharmacology

Clodronic Acid is a first-generation bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Clodronic acid adsorbs onto the surface of the hydroxyapatite crystals in bone matrix. Although the exact mechanism through which clodronic acid exerts its cytotoxic effect on osteoclasts has yet to be fully elucidated, this agent is metabolized intracellularly to a toxic beta-gamma-methylene analog of adenosine triphosphate (ATP), AppCCl2p. The ATP analog AppCCl2p competitively inhibits ADP/ATP translocase, thereby interfering with mitochondrial membrane potential and cellular energy metabolism. This may cause osteoclast apoptosis and, eventually, inhibiting osteoclast-mediated bone resorption.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Clodronate is traded under.

HS 2931.59Indicative HS code

Halogenated organo-phosphorous derivatives, other

World exports in 2024
$46.1M
+14.5% vs 2023, imports $88.5M
2022 to 2024
Top exporters
  1. China32.9%
  2. United States32.0%
  3. Germany8.4%
Top importers
  1. Brazil32.3%
  2. United States19.2%
  3. South Korea6.4%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Clodronate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Clodronate, based on the data on this page

What is Clodronate?

Clodronic acid is an organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups.

What is the CAS number of Clodronate?

The CAS registry number of Clodronate is 10596-23-3.

What is the molecular formula and weight of Clodronate?

The molecular formula of Clodronate is CH4Cl2O6P2 and its molar mass is 244.89 g/mol.

What is Clodronate used for?

Use classes: Animal Drugs.

Is Clodronate hazardous?

No GHS hazard classification for Clodronate is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Clodronate?

Clodronate is usually classified under HS code 293159 (Halogenated organo-phosphorous derivatives, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Clodronate?

CompoundList lists 44 suppliers of Clodronate in China, United States, Germany, Hong Kong and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Clodronate?

Suppliers quote Clodronate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Clodronate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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