CompoundList
Sign in
Cardiovascular and metabolic drugs

Clofibrate

Also known as Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, Ethyl clofibrate, Atromid-S

CAS 637-07-0Formula C12H15ClO3Molar mass 242.70 g/molEC 211-277-4
GHS signal word: Danger. Pictograms: Corrosive, Harmful or irritant 89 suppliers listed
Get quotes Compare 89 suppliers
Clofibrate chemical structure, C12H15ClO3, CAS 637-07-0
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Oil
Boiling point
148 to 150
Density
1.138-1.144 @ 20 °C
Solubility
INSOL IN WATER, SOL IN ALC, CHLOROFORM
HS code
291899
Category
Cardiovascular and metabolic drugs
Illustrative photo, closed amber glass reagent bottles on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Clofibrate?

Plain description, key identifiers and synonyms

Clofibrate is the ethyl ester of clofibric acid. It has a role as a geroprotector, an antilipemic drug, an anticholesteremic drug and a PPARalpha agonist. It is an ethyl ester, an aromatic ether and a member of monochlorobenzenes. It is functionally related to a clofibric acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
CAS number
637-07-0 CAS number cross-checked
EC number
211-277-4
Molecular formula
C12H15ClO3
UNII
HPN91K7FU3
MDL number
MFCD00000615
InChIKey
KNHUKKLJHYUCFP-UHFFFAOYSA-N
InChI
InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
SMILES (canonical and isomeric)
CCOC(=O)C(C)(C)OC1=CC=C(C=C1)Cl

Synonyms

  • Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
  • Ethyl clofibrate
  • Atromid-S
  • Ateriosan
  • Clofibrato
  • Amotril
  • Liprin
  • EPIB
  • Atheropront
  • Clofibratum
  • Anparton
  • Ateculon
  • Cartagyl
  • Lipavil
  • Lipavlon
  • Lipomid
  • Atromid S
  • Chlorphenisate
  • Antilipid
  • Atromidin
  • Claripex
  • Clofibate
  • Clofibrat
  • Hyclorate
  • Lipofacton
Show all 39 synonyms
  • Persantinat
  • Serotinex
  • Skleromexe
  • Azionyl
  • Neo-Atromid
  • Claripex CPIB
  • Liporil
  • Recolip
  • Regelan
  • Ethyl chlorophenoxyisobutyrate
  • Clobren-SF
  • Cinnarizin
  • ELPI
  • Normet

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Oilexp.
Odour
FAINT CHARACTERISTIC ODORexp.
Taste
FAINT CHARACTERISTIC TASTEexp.
Boiling point
148 to 150exp.
Density
1.138-1.144 @ 20 °Cexp.
Solubility
INSOL IN WATER, SOL IN ALC, CHLOROFORMexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
242.70 g/molcalc.
Exact mass
242.071 Dacalc.
LogP (octanol/water)
3.06calc.
Topological polar surface area
35.53 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
4calc.
Heavy atoms
16calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.42calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS05: Corrosive
Corrosive
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H318Causes serious eye damage.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Clofibrate suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 89 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

89 suppliers in 15 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Clofibrate price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Agent to lower plasma very-low-density-lipoprotein concn, agent to lower concn of plasma triglycerides.

Pharmacological actions

  • Anticholesteremic Agents
  • Hypolipidemic Agents

Roles

  • PPAR modulator
  • PPARalpha agonist
  • agonist
  • anticholesteremic drug
  • antilipemic drug
  • cardiovascular drug
  • geroprotector
  • pharmaceutical
  • protective agent

Pharmacology

Clofibrate is an aryloxyisobutyric acid derivate with antihyperlipidemic activity. Although the exact mechanism of action has not been fully characterized, clofibrate may enhance the conversion of very-low-density lipoprotein (VLDL) to low-density lipoprotein (LDL), decreasing the production of hepatic VLDL, inhibiting cholesterol production, and increasing fecal excretion of neutral sterols.

How it is made

Condensation of phenol with ethyl 2-chloro-2-methylpropionate in presence of a dehydrochlorinating agent, followed by chlorination and purification

Synthesized by the condensation of p-chlorophenol with acetone and chloroform and the resultant acid is esterified to give clofibrate.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Clofibrate is traded under.

HS 2918.99Indicative HS code

Carboxylic acids, with additional oxygen function (not alcohol, phenol, aldehyde or ketone)…

World exports in 2024
$1.46B
−1.1% vs 2023, imports $1.54B
2019 to 2024
Top exporters
  1. China40.0%
  2. India * partner reported26.6%
  3. Germany8.0%
Top importers
  1. United States25.6%
  2. Brazil6.7%
  3. Argentina5.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Clofibrate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Clofibrate, based on the data on this page

What is Clofibrate?

Clofibrate is the ethyl ester of clofibric acid. It has a role as a geroprotector, an antilipemic drug, an anticholesteremic drug and a PPARalpha agonist. It is an ethyl ester, an aromatic ether and a member of monochlorobenzenes. It is functionally related to a clofibric acid.

What is the CAS number of Clofibrate?

The CAS registry number of Clofibrate is 637-07-0.

What is the molecular formula and weight of Clofibrate?

The molecular formula of Clofibrate is C12H15ClO3 and its molar mass is 242.70 g/mol.

What is Clofibrate used for?

Agent to lower plasma very-low-density-lipoprotein concn, agent to lower concn of plasma triglycerides.

Is Clofibrate hazardous?

Clofibrate carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye damage. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Clofibrate?

Clofibrate is usually classified under HS code 291899 (Carboxylic acids with additional oxygen function and their anhydrides, halides…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Clofibrate?

CompoundList lists 89 suppliers of Clofibrate in United States, China, Germany, United Kingdom and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Clofibrate?

Suppliers quote Clofibrate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Clofibrate

Get quotes for Clofibrate

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Clofibrate
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Clofibrate with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/clofibrate-637-07-0" title="Clofibrate structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Cardiovascular and metabolic drugs or HS code 291899

89 suppliers
Free quotes, contact stays private
Get quotes