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Analgesics and anti-inflammatories

Clonidine

Also known as Clonidin, N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine, Chlornidinum

CAS 4205-90-7Formula C9H9Cl2N3Molar mass 230.10 g/molEC 224-119-4
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 74 suppliers listed Drug substance
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Clonidine chemical structure, C9H9Cl2N3, CAS 4205-90-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
130 °C
Solubility
Insoluble in water
HS code
293329
Category
Analgesics and anti-inflammatories
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Clonidine?

Plain description, key identifiers and synonyms

Clonidine (imino form) is a clonidine. It is a tautomer of a clonidine (amino form).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
CAS number
4205-90-7 CAS number cross-checked
EC number
224-119-4
Molecular formula
C9H9Cl2N3
UNII
MN3L5RMN02
MDL number
MFCD00055059
InChIKey
GJSURZIOUXUGAL-UHFFFAOYSA-N
InChI
InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
SMILES (canonical and isomeric)
C1CN=C(N1)NC2=C(C=CC=C2Cl)Cl

Synonyms

  • Clonidin
  • N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
  • Chlornidinum
  • Catapres-TTS
  • Catapresan
  • Catapressan
  • Clonidina
  • ST 155BS
  • Catapres-tts-1
  • Catapres-tts-2
  • Catapres-tts-3
  • Clonidinum
  • Catarpres-TTS
  • Nexiclon XR
  • 2-((2,6-Dichlorophenyl)imino)imidazolidine
  • 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine
  • Chlofazoline
  • Clonidine extended release
  • Benzenamine, 2,6-dichloro-N-2-imidazolidinylidene-
  • M 5041T
  • 2-[(2,6-Dichlorophenyl)imino]imidazoline
  • 2-[(2,6-Dichlorophenyl)imino]imidazolidine
  • Clofenil
  • Clopheline
  • Klofenil
Show all 38 synonyms
  • 2-((2,6-Dichlorophenyl)imino)imidazoline
  • Hydrochloride, Clonidine
  • Dihydrochloride, Clonidine
  • Monohydrobromide, Clonidine
  • Monohydrochloride, Clonidine
  • Clonidine Transdermal System
  • Clonidine Transdermal System USP, 0.1 mg/day
  • Clonidine Transdermal System USP, 0.2 mg/day
  • Clonidine Transdermal System USP, 0.3 mg/day
  • ST 155
  • Catapres
  • Adesipress
  • Catarpres

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Melting point
130 °Cexp.
Solubility
Insoluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
230.10 g/molcalc.
Exact mass
229.0174 Dacalc.
LogP (octanol/water)
2.36calc.
Topological polar surface area
36.42 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
14calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.22calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(NC2=NCCN2)cc1

c1ccc(NC2=NCCN2)cc1

2 rings, 12 atoms, the Imidazolidine, 2-(phenylimino)- ring system.

276 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H301Toxic if swallowed.
  • H310Fatal in contact with skin.
  • H330Fatal if inhaled.
Precautionary statements (18)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Clonidine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 74 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

74 suppliers in 18 countries

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Clonidine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Adrenergic alpha-2 Receptor Agonists
  • Analgesics
  • Antihypertensive Agents
  • Sympatholytics

Pharmacology

Clonidine is a Central alpha-2 Adrenergic Agonist. The mechanism of action of clonidine is as an Adrenergic alpha2-Agonist.

How it is made

Ammonium thiocyanate converts 2,6-dichloroaniline to the thiourea, which is treated with methyl iodide to yield the S-methylthiouronium salt. The latter compound, with ethylenediamine, closes the imidazoline ring to afford the product. (Clonidine hydrochloride)

Zeile et al, US patent 3,202,660 (1965 to Boehringer Ing). ... In shaving soap formulations, Zeile et al, US patent 3,190,802 (1965 to Boehringer Ing).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Clonidine is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Clonidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Clonidine, based on the data on this page

What is Clonidine?

Clonidine (imino form) is a clonidine. It is a tautomer of a clonidine (amino form).

What is the CAS number of Clonidine?

The CAS registry number of Clonidine is 4205-90-7.

What is the molecular formula and weight of Clonidine?

The molecular formula of Clonidine is C9H9Cl2N3 and its molar mass is 230.10 g/mol.

What is Clonidine used for?

Use classes: Pharmaceuticals.

Is Clonidine hazardous?

Clonidine carries the GHS signal word "Danger". Main hazards: toxic if swallowed, fatal in contact with skin, fatal if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Clonidine?

Clonidine is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Clonidine?

CompoundList lists 74 suppliers of Clonidine in United States, China, India, Germany and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Clonidine in India?

9 suppliers in India list Clonidine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Clonidine?

Suppliers quote Clonidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Clonidine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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