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Screening compounds

Copanlisib

Also known as BAY 80-6946, Aliqopa, BAY 80-6946 (Copanlisib)

CAS 1032568-63-0Formula C23H28N8O4Molar mass 480.53 g/mol
8 suppliers listed
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Copanlisib chemical structure, C23H28N8O4, CAS 1032568-63-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
1032568-63-0
Formula
C23H28N8O4
Molar mass
480.53 g/mol
HS code
293499
Category
Screening compounds

What is Copanlisib?

Plain description, key identifiers and synonyms

Copanlisib is an imidazoquinazoline that is 2,3-dihydroimidazo[1,2-c]quinazoline substituted by (2-aminopyrimidine-5-carbonyl)amino, methoxy, and 3-(morpholin-4-yl)propoxy groups at positions 5, 7 and 8, respectively. It is a intravenous pan-class I PI3K inhibitor used for the treatment of relapsed follicular lymphoma in patients who have received at least 2 prior systemic therapies. It has a role as an antineoplastic agent, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an apoptosis inducer. It is a secondary carboxamide, an aromatic ether, an aminopyrimidine, a member of morpholines, a diether, an imidazoquinazoline, a pyrimidinecarboxamide and a tertiary amino compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene]pyrimidine-5-carboxamide
CAS number
1032568-63-0 CAS number cross-checked
Molecular formula
C23H28N8O4
UNII
WI6V529FZ9
MDL number
MFCD18633201
InChIKey
MWYDSXOGIBMAET-UHFFFAOYSA-N
InChI
InChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14,25H,2,5-12H2,1H3,(H2,24,26,27)
SMILES (canonical and isomeric)
COC1=C(C=CC2=C3NCCN3C(=NC(=O)C4=CN=C(N=C4)N)N=C21)OCCCN5CCOCC5

Synonyms

  • BAY 80-6946
  • Aliqopa
  • BAY 80-6946 (Copanlisib)
  • 2-amino-N-(7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyrimidine-5-carboxamide
  • 2-Amino-N-[2,3-dihydro-7-methoxy-8-[3-(4-morpholinyl)propoxy]imidazo[1,2-c]quinazolin-5-yl]-5-pyrimidinecarboxamide
  • Copanlisib (BAY 80-6946)
  • 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene]pyrimidine-5-carboxamide
  • 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide
  • 2-amino-N-{7-methoxy-8-[3-(morpholin-4-yl)propoxy]-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl}pyrimidine-5-carboxamide
  • copanlisibum
  • 2-Amino-N-(7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo(1,2-c)quinazolin-5-yl)pyrimidine-5-carboxamide
  • 2-amino-N-[7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide
  • Copanlisib tris-HCl
  • Copanlisib (Standard)
  • Copanlisib (USAN/INN)
  • BAY 80-6946, Copanlisib
  • BAY-80-6946 tris-HCl
  • Copanlisib, BAY-80-6946
  • BAY 80-6946(Copanlisib)?
  • 5-Pyrimidinecarboxamide, 2-ami
  • 2-Amino-N-(7-methoxy-8-(3-(morpholin-4-yl)propoxy)-2,3-dihydroimidazo(1,2-c)quinazolin-5-yl(pyrimidine-5-carboxamide
  • 2-amino-N-(7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo(1,2-c)quinazolin-4-yl)pyrimidine-5-carboxamide
  • 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1.2-c]quinazolin-5-yl]pyrimidine-5-carboxamide
  • 2-amino-N-[7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene]pyrimidine-5-carboxamide
  • 5-Pyrimidinecarboxamide, 2-amino-N-(2,3-dihydro-7-methoxy-8-(3-(4-morpholinyl)propoxy)imidazo(1,2-c)quinazolin-5-yl)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
480.53 g/molcalc.
Exact mass
480.2234 Dacalc.
LogP (octanol/water)
0.68calc.
Topological polar surface area
142 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
10calc.
Rotatable bonds
7calc.
Heavy atoms
35calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.44calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(N=c1nc2cc(OCCCN3CCOCC3)ccc2c2n1CCN2)c1cncnc1

O=C(N=c1nc2cc(OCCCN3CCOCC3)ccc2c2n1CCN2)c1cncnc1

5 rings, 32 atoms.

5 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Copanlisib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 8 suppliers
8 of 8 offers

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Where suppliers are based

8 suppliers in 3 countries

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Copanlisib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • apoptosis inducer
  • enzyme inhibitor
  • lipid kinase inhibitor
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Copanlisib is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Copanlisib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Copanlisib, based on the data on this page

What is Copanlisib?

Copanlisib is an imidazoquinazoline that is 2,3-dihydroimidazo[1,2-c]quinazoline substituted by (2-aminopyrimidine-5-carbonyl)amino, methoxy, and 3-(morpholin-4-yl)propoxy groups at positions 5, 7 and 8, respectively.

What is the CAS number of Copanlisib?

The CAS registry number of Copanlisib is 1032568-63-0.

What is the molecular formula and weight of Copanlisib?

The molecular formula of Copanlisib is C23H28N8O4 and its molar mass is 480.53 g/mol.

What is Copanlisib used for?

Known uses and roles of Copanlisib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, apoptosis inducer, enzyme inhibitor and 2 more.

Is Copanlisib hazardous?

No GHS hazard classification for Copanlisib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Copanlisib?

Copanlisib is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Copanlisib?

CompoundList lists 8 suppliers of Copanlisib in China, United States and Canada. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Copanlisib?

Suppliers quote Copanlisib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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