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Cosmetic antioxidants

Crocin

Also known as Crocine, Crocin 1, alpha-Crocin

CAS 42553-65-1Formula C44H64O24Molar mass 976.97 g/molEC 254-465-1
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Crocin chemical structure, C44H64O24, CAS 42553-65-1
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Solid /Di-gentiobiose ester/
Melting point
186 °C
Solubility
Freely soluble in hot water, giving an orange-colored solution /Di-gentiobiose ester/
HS code
320418
Category
Cosmetic antioxidants
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Crocin?

Plain description, key identifiers and synonyms

Crocin-1 is a diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters. It is one of the water-soluble yellow-red pigments of saffron and is used as a spice for flavouring and colouring food. Note that in India, the term 'Crocin' is also used by GlaxoSmithKline as a brand-name for paracetamol. It has a role as an antioxidant, a plant metabolite, a histological dye and a food colouring. It is a diterpenoid, a diester and a disaccharide derivative. It is functionally related to a gentiobiose and a beta-D-gentiobiosyl crocetin.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate
CAS number
42553-65-1 CAS number cross-checkedOther or deprecated CAS: 11012-59-2, 39465-00-4, 94238-00-3
EC numbers
254-465-1, 255-881-6, 692-668-0
Molecular formula
C44H64O24
UNII
877GWI46C2, F32BA2H92Z
INCI name
CROCIN
InChIKey
SEBIKDIMAPSUBY-RTJKDTQDSA-N
InChI
InChI=1S/C44H64O24/c1-19(11-7-13-21(3)39(59)67-43-37(57)33(53)29(49)25(65-43)17-61-41-35(55)31(51)27(47)23(15-45)63-41)9-5-6-10-20(2)12-8-14-22(4)40(60)68-44-38(58)34(54)30(50)26(66-44)18-62-42-36(56)32(52)28(48)24(16-46)64-42/h5-14,23-38,41-58H,15-18H2,1-4H3/b6-5+,11-7+,12-8+,19-9+,20-10+,21-13+,22-14+/t23-,24-,25-,26-,27-,28-,29-,30-,31+,32+,33+,34+,35-,36-,37-,38-,41-,42-,43+,44+/m1/s1
Canonical SMILES
CC(C=CC=C(C)C(=O)OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)=CC=CC=C(C)C=CC=C(C)C(=O)OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O
Isomeric SMILES
C/C(=C\C=C\C=C(\C=C\C=C(\C(=O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO)/C)/C)/C=C/C=C(/C(=O)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)\C

Synonyms

  • Crocine
  • Crocin 1
  • alpha-Crocin
  • Crocin A
  • Crocetin bis(gentiobiosyl) ester
  • trans-Crocetin di(beta-D-gentiobiosyl) ester
  • crocetin di-gentiobiose ester
  • all-trans-Crocetin di-beta-D-gentiobiosyl ester
  • 8,8'-Diapo-psi,psi-carotenedioic acid, bis(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl) ester
  • beta-D-Glucopyranose, 6-O-beta-D-glucopyranosyl-, 1,1'-((2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate)
  • Crocin I
  • Gardenia Yellow
  • Crocetin digentiobiose ester
  • crocin-1
  • crocetin digentiobioside
  • trans-crocetin bis(beta-D-gentiobiosyl) ester
  • trans-Crocin
  • trans-Crocin-4
  • trans-crocin 4
  • Natural red 1
  • Natural yellow 19
  • trans-4-GG
  • bis-gentiobiosyl-crocetin
  • Crocin - microscopy grade
  • Bis(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl) 8,8'-diapo-psi,psi-carotenedioate
Show all 31 synonyms
  • crocetin-di-beta-D-gentiobioside
  • bis(beta-D-gentiobiosyl) crocetin
  • Crocetin Di(Beta-Gentiobiosyl)Ester
  • crocetin di-beta-D-gentiobiose ester
  • crocetin di (beta-gentiobiosyl) ester
  • crocetin di(beta-D-gentabiosyl) ester

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Solid /Di-gentiobiose ester/exp.
Melting point
186 °Cexp.
Solubility
Freely soluble in hot water, giving an orange-colored solution /Di-gentiobiose ester/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
976.97 g/molcalc.
Exact mass
976.3788 Dacalc.
LogP (octanol/water)
-5.23calc.
Topological polar surface area
391.2 Ųcalc.
Hydrogen bond donors
14calc.
Hydrogen bond acceptors
24calc.
Rotatable bonds
18calc.
Heavy atoms
68calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.64calc.
Formal charge
0calc.
Stereocentres
20calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(C=CC=CC=CC=CC=CC=CC=CC(=O)OC1CCCC(COC2CCCCO2)O1)OC1CCCC(COC2CCCCO2)O1

O=C(C=CC=CC=CC=CC=CC=CC=CC(=O)OC1CCCC(COC2CCCCO2)O1)OC1CCCC(COC2CCCCO2)O1

4 rings, 48 atoms.

5 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS classification
Hazard pictograms

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Crocin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 29 suppliers
29 of 29 offers
  • Gihi Chemicals Co.,Limited
    China ManufacturerUnclaimed profile
    CrocinGrade, purity and minimum order on request
    Price on request
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  • Changsha World-Way Inc
    China, ChangshaUnclaimed profile
    CrocinGrade, purity and minimum order on request
    Price on request
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  • Aaron Chemicals LLC.
    China, NanjingUnclaimed profile
    CrocinGrade, purity and minimum order on request
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  • Abmole Bioscience Inc.
    United States, HoustonUnclaimed profile
    CrocinGrade, purity and minimum order on request
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  • Achemtek
    United States, WoburnUnclaimed profile
    CrocinGrade, purity and minimum order on request
    Price on request
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  • Acmec Biochemical
    China, ShanghaiUnclaimed profile
    CrocinGrade, purity and minimum order on request
    Price on request
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  • Acorn PharmaTech, LLC
    United States, Redwood CityUnclaimed profile
    CrocinGrade, purity and minimum order on request
    Price on request
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  • AiFChem
    United States, SomervilleUnclaimed profile
    CrocinGrade, purity and minimum order on request
    Price on request
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  • Ambeed, Inc.
    United States, Buffalo GroveUnclaimed profile
    CrocinGrade, purity and minimum order on request
    Price on request
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  • AvaChem Scientific LLC
    United StatesUnclaimed profile
    CrocinGrade, purity and minimum order on request
    Price on request
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

29 suppliers in 6 countries

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Crocin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Crocin dyes, isolated from Gardenia jasminodes... the crocin dyes are safe for coloring foods. (Crocin dyes).

Laboratory reagent (Di-gentiobiose ester).

Cosmetic ingredient, INCI name CROCIN(antioxidant, colorant)

Roles

  • additive
  • anti-inflammatory agent
  • antioxidant
  • dye
  • eukaryotic metabolite
  • food additive
  • food colouring
  • food component
  • histological dye
  • metabolite
  • physiological role
  • plant metabolite

Functional uses

  • Antioxidant
  • Dye

Cosmetic functions

  • Antioxidant
  • Colorant

How it is made

Total crocin was extracted from saffron stigmas using crystallization method. Ethanol 80% was selected as the best extraction solvent. Crystallization process was carried out in one and two steps at different temperatures. Ethanol 80% was used as crystallization medium. Crocin crystals obtained from the first crystallization had low purity and thus were subjected to the second crystallization. The higher purity crystals were yielded in the second crystallization at -5 degrees C.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Crocin is traded under.

HS 3204.18Indicative HS code

Carotenoid colouring matters and preparations based thereon

World exports in 2024
$696M
+8.0% vs 2023, imports $526M
2022 to 2024
Top exporters
  1. France * partner reported34.6%
  2. Netherlands31.7%
  3. Germany12.1%
Top importers
  1. Netherlands34.7%
  2. China6.3%
  3. France * partner reported5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Crocin is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Crocin, based on the data on this page

What is Crocin?

Crocin-1 is a diester that is crocetin in which both of the carboxy groups have been converted to their gentiobiosyl esters. It is one of the water-soluble yellow-red pigments of saffron and is used as a spice for flavouring and colouring food.

What is the CAS number of Crocin?

The CAS registry number of Crocin is 42553-65-1. Other or deprecated CAS numbers: 11012-59-2, 39465-00-4, 94238-00-3.

What is the molecular formula and weight of Crocin?

The molecular formula of Crocin is C44H64O24 and its molar mass is 976.97 g/mol.

What is Crocin used for?

Crocin dyes, isolated from Gardenia jasminodes... the crocin dyes are safe for coloring foods. (Crocin dyes). Laboratory reagent (Di-gentiobiose ester).

Is Crocin hazardous?

No GHS hazard classification for Crocin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Crocin?

Crocin is usually classified under HS code 320418 (Carotenoid colouring matters and preparations based thereon). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Crocin?

CompoundList lists 29 suppliers of Crocin in China, United States, Germany, United Kingdom and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Crocin?

Suppliers quote Crocin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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