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Screening compounds

Culmerciclib

Also known as 5-fluoro-4-(2-methyl-3-propan-2-ylindazol-5-yl)-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amine, 2-Pyrimidinamine, 5-fluoro-4-(2-methyl-3-(1-methylethyl)-2H-indazol-5-yl)-N-(5-(1-piperazinyl)-2-pyridinyl)-, 5-Fluoro-4-(2-methyl-3-(1-methylethyl)-2H-indazol-5-yl)-N-(5-(1-piperazinyl)-2-pyridinyl)-2-pyrimidinamine

CAS 2004705-28-4Formula C24H27FN8Molar mass 446.53 g/mol
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Culmerciclib chemical structure, C24H27FN8, CAS 2004705-28-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2004705-28-4
Formula
C24H27FN8
Molar mass
446.53 g/mol
HS code
293359
Category
Screening compounds

What is Culmerciclib?

Plain description, key identifiers and synonyms

Culmerciclib is an orally bioavailable, selective inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral administration, culmerciclib selectively inhibits CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase, prevents CDK-mediated G1-S-phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of both cell cycle progression from the G1-phase into the S-phase and tumor cell proliferation.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-fluoro-4-(2-methyl-3-propan-2-ylindazol-5-yl)-N-(5-piperazin-1-yl-2-pyridinyl)pyrimidin-2-amine
CAS number
2004705-28-4
Molecular formula
C24H27FN8
UNII
ZU5GL4E4WH
InChIKey
LLFOBMRPWNABCB-UHFFFAOYSA-N
InChI
InChI=1S/C24H27FN8/c1-15(2)23-18-12-16(4-6-20(18)31-32(23)3)22-19(25)14-28-24(30-22)29-21-7-5-17(13-27-21)33-10-8-26-9-11-33/h4-7,12-15,26H,8-11H2,1-3H3,(H,27,28,29,30)
SMILES (canonical and isomeric)
CC(C)C1=C2C=C(C=CC2=NN1C)C3=NC(=NC=C3F)NC4=NC=C(C=C4)N5CCNCC5

Synonyms

  • 5-fluoro-4-(2-methyl-3-propan-2-ylindazol-5-yl)-N-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amine
  • 2-Pyrimidinamine, 5-fluoro-4-(2-methyl-3-(1-methylethyl)-2H-indazol-5-yl)-N-(5-(1-piperazinyl)-2-pyridinyl)-
  • 5-Fluoro-4-(2-methyl-3-(1-methylethyl)-2H-indazol-5-yl)-N-(5-(1-piperazinyl)-2-pyridinyl)-2-pyrimidinamine
  • 5-Fluoro-4-(2-methyl-3-(propan-2-yl)-2H-indazol-5-yl)- N-(5-(piperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine
  • Saitanxin (China)
  • 2-Pyrimidinamine, 5-fluoro-4-[2-methyl-3-(1-methylethyl)-2H-indazol-5-yl]-N-[5-(1-piperazinyl)-2-pyridinyl]-
  • 5-Fluoro-4-[2-methyl-3-(1-methylethyl)-2H-indazol-5-yl]-N-[5-(1-piperazinyl)-2-pyridinyl]-2-pyrimidinamine
  • 5-fluoro-4-[2-methyl-3-(propan-2-yl)-2H-indazol-5-yl]- N-[5-(piperazin-1-yl)pyridin-2-yl]pyrimidin-2-amine
  • compound 23a
  • 5-fluoro-4-(2-methyl-3-propan-2-ylindazol-5-yl)-N-(5-piperazin-1-yl-2-pyridinyl)pyrimidin-2-amine
  • 5-Fluoro-4-(3-isopropyl-2-methyl-2H-indazol-5-yl)-N-(5-(piperazin-1-yl)pyridin-2-yl)pyrimidin-2-amine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
446.53 g/molcalc.
Exact mass
446.2343 Dacalc.
LogP (octanol/water)
3.84calc.
Topological polar surface area
83.79 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
7calc.
Rotatable bonds
5calc.
Heavy atoms
33calc.
Rings
5calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1cc(-c2ccc3n[nH]cc3c2)nc(Nc2ccc(N3CCNCC3)cn2)n1

c1cc(-c2ccc3n[nH]cc3c2)nc(Nc2ccc(N3CCNCC3)cn2)n1

5 rings, 28 atoms.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Culmerciclib suppliers

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Culmerciclib price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Culmerciclib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Culmerciclib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Culmerciclib, based on the data on this page

What is Culmerciclib?

Culmerciclib is an orally bioavailable, selective inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity.

What is the CAS number of Culmerciclib?

The CAS registry number of Culmerciclib is 2004705-28-4.

What is the molecular formula and weight of Culmerciclib?

The molecular formula of Culmerciclib is C24H27FN8 and its molar mass is 446.53 g/mol.

What is Culmerciclib used for?

Known uses and roles of Culmerciclib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Culmerciclib hazardous?

No GHS hazard classification for Culmerciclib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Culmerciclib?

Culmerciclib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Culmerciclib?

Post a free request on CompoundList and suppliers of Culmerciclib will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Culmerciclib?

Suppliers quote Culmerciclib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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