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Nitriles, nitro and azo compounds

Cupferron

Also known as Cupferon, Kupferon, Ammonium cupferron

CAS 135-20-6Formula C6H9N3O2Molar mass 155.16 g/molEC 205-183-2
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard 13 suppliers listed
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Cupferron chemical structure, C6H9N3O2, CAS 135-20-6
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
163.5 °C
Solubility
Freely soluble in water
HS code
292800
Category
Nitriles, nitro and azo compounds
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Cupferron?

Plain description, key identifiers and synonyms

Cupferron is a creamy, white crystalline substance. Cupferron is used as an analytical reagent to separate copper, iron and vanadium from other metals. Exposure to this substance causes gastrointestinal disturbances and skin, eye and respiratory-tract irritation. Cupferron is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
azanium N-oxido-N-phenylnitrous amide
CAS number
135-20-6 CAS number cross-checked
EC number
205-183-2
Molecular formula
C6H9N3O2
InChIKey
GDEBSAWXIHEMNF-UHFFFAOYSA-O
InChI
InChI=1S/C6H5N2O2.H3N/c9-7-8(10)6-4-2-1-3-5-6;/h1-5H;1H3/q-1;/p+1
SMILES (canonical and isomeric)
C1=CC=C(C=C1)N(N=O)[O-].[NH4+]

Synonyms

  • Cupferon
  • Kupferon
  • Ammonium cupferron
  • Ammonium-N-nitrosophenylhydroxylamine
  • N-Nitrosophenylhydroxylamine ammonium salt
  • Cupferron, ammonium salt
  • N-Nitroso-N-phenylhydroxylamine ammonium salt
  • N-Nitrosofenylhydroxylamin amonny
  • Ammonium N-nitrosophenylhydroxylamine
  • Ammonium nitroso-beta-phenylhydroxylamine
  • N-Nitrosophenylhydroxylamin ammonium salz
  • N-Nitroso-N-phenylhydroxyamine ammonium salt
  • N-Hydroxy-N-nitroso-benzenamine, ammonium salt
  • Hydroxylamine, N-nitroso-N-phenyl-, ammonium salt
  • Benzenamine, N-hydroxy-N-nitroso-, ammonium salt
  • Ammonium N-hydroxy-N-nitrosobenzenamine
  • azane, N-hydroxy-N-phenylnitrous amide
  • hydrogen cupferron
  • Inhibitor NPH
  • Kupferron
  • N-Nitroso-N-phenylhydroxylamine, ammonium salt
  • Cupferron, acs

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Melting point
163.5 °Cexp.
Solubility
Freely soluble in waterexp.
Vapour pressure
Negligibleexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
155.16 g/molcalc.
Exact mass
155.0695 Dacalc.
LogP (octanol/water)
2.05calc.
Topological polar surface area
92.23 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
2calc.
Heavy atoms
11calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Components
2calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H301Toxic if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H351Suspected of causing cancer.
Precautionary statements (21)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cupferron suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 13 suppliers
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Where suppliers are based

13 suppliers in 5 countries

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Cupferron price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

As a reagent for separating Sn from Zn, and Cu from Fe from other metals. Precipitates iron quantitatively from strongly acid solution, as a quantitative reagent for vanadates with which it gives a dark-rep precipitate solution in alkali solution, for Ti with which it form as a yellow precipitate, also suitable for the coloration estimation of Al.

Reagent chemical ... manufactured to high and well-defined standards of purity.

How it is made

By treating an ether solution of beta-phenylhydroxylamine with dry ammonia gas and amyl nitrite.

Reaction of phenylhydroxylamine with sodium nitrite in the presence of hydrochloric acid, followed by treatment with ammonia, treatment of phenylhydroxylamine with butyl or amyl nitrite and ammonia

Prepared from phenylhydroxylamine by treating with NaNO2 at 0 °C in presence of HCl, filtering, dissolving in ether and treating with NH3, or by treating an ether solution of phenylhydroxylamine with butyl or amyl nitrite and NH3 in the cold.

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cupferron is traded under.

HS 2928.00Indicative HS code

Organic derivatives of hydrazine or of hydroxylamine

World exports in 2024
$1.38B
−9.0% vs 2023, imports $1.52B
2019 to 2024
Top exporters
  1. Switzerland * partner reported44.0%
  2. China18.4%
  3. Italy9.4%
Top importers
  1. Brazil21.8%
  2. United States12.8%
  3. Italy10.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cupferron is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cupferron, based on the data on this page

What is Cupferron?

Cupferron is a creamy, white crystalline substance. Cupferron is used as an analytical reagent to separate copper, iron and vanadium from other metals. Exposure to this substance causes gastrointestinal disturbances and skin, eye and respiratory-tract irritation.

What is the CAS number of Cupferron?

The CAS registry number of Cupferron is 135-20-6.

What is the molecular formula and weight of Cupferron?

The molecular formula of Cupferron is C6H9N3O2 and its molar mass is 155.16 g/mol.

What is Cupferron used for?

As a reagent for separating Sn from Zn, and Cu from Fe from other metals. Precipitates iron quantitatively from strongly acid solution, as a quantitative reagent for vanadates with which it gives a dark-rep precipitate solution in alkali solution, for Ti with which it form as a yellow precipitate, also suitable for th…

Is Cupferron hazardous?

Cupferron carries the GHS signal word "Danger". Main hazards: toxic if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cupferron?

Cupferron is usually classified under HS code 292800 (Organic derivatives of hydrazine or of hydroxylamine). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cupferron?

CompoundList lists 13 suppliers of Cupferron in China, India, United States, Switzerland and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Cupferron in India?

2 suppliers in India list Cupferron on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Cupferron?

Suppliers quote Cupferron on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cupferron

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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