CompoundList
Sign in
Sweeteners

Cyclamate

Also known as Cyclamic acid, Cyclohexylsulfamic acid, N-Cyclohexylsulfamic acid

CAS 100-88-9Formula C6H13NO3SMolar mass 179.24 g/molEC 202-898-1
GHS signal word: Warning. Pictograms: Harmful or irritant 40 suppliers listed
Get quotes Compare 40 suppliers
Cyclamate chemical structure, C6H13NO3S, CAS 100-88-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
169.5 °C
Solubility
1 G DISSOLVES IN ABOUT 7.5 ML OF WATER, 4 ML OF ALC, 4 ML OF PROPYLENE GLYCOL, OR 6 ML O…
HS code
294200
Category
Sweeteners
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Cyclamate?

Plain description, key identifiers and synonyms

Cyclohexylsulfamic acid is a member of the class of sulfamic acids that is sulfamic acid carrying an N-cyclohexyl substituent. It has a role as a human xenobiotic metabolite and an environmental contaminant. It is functionally related to a sulfamic acid. It is a conjugate acid of a cyclohexylsulfamate.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
cyclohexylsulfamic acid
CAS number
100-88-9 CAS number cross-checked
EC number
202-898-1
Molecular formula
C6H13NO3S
UNII
HN3OFO5036
MDL number
MFCD00065234
InChIKey
HCAJEUSONLESMK-UHFFFAOYSA-N
InChI
InChI=1S/C6H13NO3S/c8-11(9,10)7-6-4-2-1-3-5-6/h6-7H,1-5H2,(H,8,9,10)
SMILES (canonical and isomeric)
C1CCC(CC1)NS(=O)(=O)O

Synonyms

  • Cyclamic acid
  • Cyclohexylsulfamic acid
  • N-Cyclohexylsulfamic acid
  • Cyclohexanesulfamic acid
  • Hexamic acid
  • Sucaryl acid
  • Sucaryl
  • Cyclohexylaminesulphonic acid
  • Cyclohexylamidosulfuric acid
  • Cyclohexylaminesulfonic acid
  • Cyclohexylsulphamic acid
  • Cyclamsaeure
  • Cyclohexanesulphamic acid
  • Cyclohexylamidosulphuric acid
  • INS NO.952(I)
  • INS-952(I)
  • E-952(I)
  • (sulfonatoazaniumyl)cyclohexane
  • Sulfamic acid, cyclohexyl-
  • N-Cyclohexylsulphamic acid
  • Zyklamat
  • Cyclohexylamide sulfate
  • Cylamic acid
  • Cyclohexylamine sulfamic acid
  • Sulfamic acid, N-cyclohexyl-
Show all 34 synonyms
  • cyclamic-acid
  • Hexamic acid (TN)
  • Cyclamic acid (USAN)
  • Cyclohexylsulfamic acid, Cyclamate
  • N-Cyclohexyl-Sulfuric acid monoamide
  • N-?Cyclohexylsulfamic Acid(Cyclamic Acid)
  • Calciumlevulinate
  • N-Cyclohexylsulfamsaeure
  • Sulfuric acid monoamide, N-cyclohexyl-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Odour
Odorlessexp.
Taste
Sweet-sourexp.
Melting point
169.5 °Cexp.
Solubility
1 G DISSOLVES IN ABOUT 7.5 ML OF WATER, 4 ML OF ALC, 4 ML OF PROPYLENE GLYCOL, OR 6 ML OF ACETONE, SLIGHTLY SOL IN CHLOROFORM AND INSOL IN HEXANEexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
179.24 g/molcalc.
Exact mass
179.0616 Dacalc.
LogP (octanol/water)
0.71calc.
Topological polar surface area
66.4 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
2calc.
Heavy atoms
11calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
1calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCCCC1

C1CCCCC1

1 ring, 6 atoms, the Cyclohexane ring system.

24,737 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cyclamate suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 40 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

40 suppliers in 11 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Cyclamate price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Non-nutritive sweetener.

Acidulant.

Sodium and calcium cyclamates are used as non-nutritive sweeteners ... Calcium cyclamate is used in low-sodium and sodium-free products (Cyclamate salts).

Chemical intermediate for salts (noncaloric sweeteners).

The main application of cyclamates ... is in blends with saccharin in a 10:1 ratio by weight. In these blends, quantitative and qualitative synergistic effects can be used to advantage, rendering them an important sweetener system in countries approving the use of both sweeteners.

Industrial uses: Cleaning agent.

Consumer uses: Cleaning agent.

Industries and functions

Roles

  • animal metabolite
  • environmental contaminant
  • eukaryotic metabolite
  • human metabolite
  • human xenobiotic metabolite
  • mammalian metabolite
  • metabolite
  • xenobiotic metabolite

How it is made

The starting material for cyclamate production is cyclohexylamine, which is reacted with sulfonating agents. The originally used chlorosulfonic acid has been replaced by other compounds. In high-boiling-point solvents, cyclohexylamine reacts with sulfamic acid to N-cyclohexyl-N-cyclohexylammonium sulfamate. Reaction with sodium or calcium hydroxide yields cyclamates and free cyclohexylamine.

Read more

In a corresponding way, equimolar amounts of cyclohexylamine and tertiary amines react to trialkylammonium-N-cyclohexyl sulfamates, the respective cyclamates being formed after reaction with sodium or calcium hydroxide.

Cyclamic acid was synthesized by the reaction of barium-N-cyclohexylsulphamate (made by the sulphonation of cyclohexylamine with chlorosulphonic acid in chloroform followed by treatment with barium hydroxide) with sulphuric acid.

Sodium cyclamate was synthesized ... by the sulfonation of cyclohexylamine with chlorosulfonic acid in chloroform to produce cyclohexylammonium N-cyclohexylsulfamate, which was then treated with sodium hydroxide. Sodium cyclamate has also been made by the reaction of nitrocyclohexane with sodium dithionite in aqueous solution in the presence of trisodium phosphate. (Sodium cyclamate)

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cyclamate is traded under.

HS 2942.00Indicative HS code

Organic compounds not elsewhere classified in chapter 29

World exports in 2024
$589M
−43.5% vs 2023, imports $614M
2019 to 2024
Top exporters
  1. India * partner reported20.7%
  2. United States18.6%
  3. Italy10.4%
Top importers
  1. United States15.1%
  2. Italy6.7%
  3. Japan5.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cyclamate is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cyclamate, based on the data on this page

What is Cyclamate?

Cyclohexylsulfamic acid is a member of the class of sulfamic acids that is sulfamic acid carrying an N-cyclohexyl substituent. It has a role as a human xenobiotic metabolite and an environmental contaminant. It is functionally related to a sulfamic acid. It is a conjugate acid of a cyclohexylsulfamate.

What is the CAS number of Cyclamate?

The CAS registry number of Cyclamate is 100-88-9.

What is the molecular formula and weight of Cyclamate?

The molecular formula of Cyclamate is C6H13NO3S and its molar mass is 179.24 g/mol.

What is Cyclamate used for?

Non-nutritive sweetener. Acidulant. Sodium and calcium cyclamates are used as non-nutritive sweeteners ... Calcium cyclamate is used in low-sodium and sodium-free products (Cyclamate salts). Chemical intermediate for salts (noncaloric sweeteners). The main application of cyclamates ...

Is Cyclamate hazardous?

Cyclamate carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cyclamate?

Cyclamate is usually classified under HS code 294200 (XIII. OTHER ORGANIC COMPOUNDS, other organic compounds). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cyclamate?

CompoundList lists 40 suppliers of Cyclamate in China, United States, Japan, Spain and 7 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Cyclamate in India?

1 supplier in India list Cyclamate on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Cyclamate?

Suppliers quote Cyclamate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cyclamate

Get quotes for Cyclamate

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Cyclamate
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Cyclamate with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/cyclamate-100-88-9" title="Cyclamate structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Sweeteners or HS code 294200

40 suppliers
Free quotes, contact stays private
Get quotes