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Cardiovascular and metabolic drugs

Cyclandelate

Also known as Cyclomandol, Cyclolyt, Cyclospasmol

CAS 456-59-7Formula C17H24O3Molar mass 276.38 g/molEC 207-271-6
GHS signal word: Warning. Pictograms: Harmful or irritant 6 suppliers listed
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Cyclandelate chemical structure, C17H24O3, CAS 456-59-7
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
50 to 53
Boiling point
192 to 194
Solubility
PRACTICALLY INSOL IN WATER, SOL IN LIPOIDS & THEIR SOLVENTS
HS code
291819
Category
Cardiovascular and metabolic drugs
Illustrative photo, closed jumbo bulk bags in a warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Cyclandelate?

Plain description, key identifiers and synonyms

Cyclandelate is the ester obtained by formal condensation of mandelic acid and 3,3,5-tricyclohexanol. It is a direct-acting smooth muscle relaxant used to dilate blood vessels. It has a role as a vasodilator agent. It is a carboxylic ester and a secondary alcohol. It is functionally related to a mandelic acid and a 3,3,5-trimethylcyclohexanol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3,3,5-trimethylcyclohexyl) 2-hydroxy-2-phenylacetate
CAS number
456-59-7 CAS number cross-checked
EC number
207-271-6
Molecular formula
C17H24O3
UNII
4139O1OAY2
MDL number
MFCD00056623
InChIKey
WZHCOOQXZCIUNC-UHFFFAOYSA-N
InChI
InChI=1S/C17H24O3/c1-12-9-14(11-17(2,3)10-12)20-16(19)15(18)13-7-5-4-6-8-13/h4-8,12,14-15,18H,9-11H2,1-3H3
SMILES (canonical and isomeric)
CC1CC(CC(C1)(C)C)OC(=O)C(C2=CC=CC=C2)O

Synonyms

  • Cyclomandol
  • Cyclolyt
  • Cyclospasmol
  • Perebral
  • Spasmione
  • Capilan
  • Sepyron
  • Ciclandelato
  • Ciclospasmol
  • Clandilon
  • Cyclergine
  • Cyclobral
  • Saiclate
  • Sancyclan
  • Spasmocyclon
  • Arto-espasmol
  • 3,3,5-Trimethylcyclohexyl mandelate
  • Novodil
  • Natil
  • 3,5,5-Trimethylcyclohexyl mandelate
  • Cyclandelatum
  • 3,5,5-Trimethylcyclohexyl amygdalate
  • BS 572
  • 3,3,5-trimethylcyclohexyl 2-hydroxy-2-phenylacetate
  • Spasmocyclon (3m)
Show all 35 synonyms
  • Benzeneacetic acid, alpha-hydroxy-, 3,3,5-trimethylcyclohexyl ester
  • Mandelic acid, 3,3,5-trimethylcyclohexyl ester
  • 3,5,5-Trimethylcyclohexanol, mandelic acid ester
  • 3,3,5-Trimethylcyclohexanol alpha-phenyl-alpha-hydroxyacetate
  • Spasmocyclone
  • (3,3,5-trimethylcyclohexyl) 2-hydroxy-2-phenylacetate
  • Mandelic Acid 3,3,5-Trimethylcyclohexyl Ester
  • 3,3,5-Trimethylcyclohexyl hydroxy(phenyl)acetate
  • (3,3,5-trimethylcyclohexyl) 2-hydroxy-2-phenyl-acetate
  • Cyclandelate (>85%)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Melting point
50 to 53exp.
Boiling point
192 to 194exp.
Solubility
PRACTICALLY INSOL IN WATER, SOL IN LIPOIDS & THEIR SOLVENTSexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
276.38 g/molcalc.
Exact mass
276.1725 Dacalc.
LogP (octanol/water)
3.48calc.
Topological polar surface area
46.53 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
20calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.59calc.
Formal charge
0calc.
Stereocentres
3calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Cc1ccccc1)OC1CCCCC1

O=C(Cc1ccccc1)OC1CCCCC1

2 rings, 16 atoms, the Benzeneacetic acid, cyclohexyl ester ring system.

20 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H319Causes serious eye irritation.
Precautionary statements (4)
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P337 + P317If eye irritation persists: Get medical help.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cyclandelate suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 6 suppliers
6 of 6 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

6 suppliers in 3 countries

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Cyclandelate price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Vasodilator Agents

Roles

  • cardiovascular drug
  • pharmaceutical
  • vasodilator agent

How it is made

Prepd by esterification of mandelic acid with 3, 3,5-trimethylcyclohexanol using sulfuric acid as catalyst: brock et al, arzneimittel-forsch 2, 165 (1952), funcke et al, ibid 3, 503 (1953)...british patent 707.227 (1954 to brocades-stheeman). Purification: flitter, us patent 3,663,597 (1972 to american home products).

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cyclandelate is traded under.

HS 2918.19Indicative HS code

Carboxylic acids with alcohol function but without other oxygen function, their…

World exports in 2024
$1.37B
+0.5% vs 2023, imports $1.18B
2019 to 2024
Top exporters
  1. China23.7%
  2. Italy14.7%
  3. India * partner reported12.0%
Top importers
  1. Germany11.7%
  2. South Korea9.8%
  3. Italy9.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Cyclandelate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cyclandelate, based on the data on this page

What is Cyclandelate?

Cyclandelate is the ester obtained by formal condensation of mandelic acid and 3,3,5-tricyclohexanol. It is a direct-acting smooth muscle relaxant used to dilate blood vessels. It has a role as a vasodilator agent. It is a carboxylic ester and a secondary alcohol.

What is the CAS number of Cyclandelate?

The CAS registry number of Cyclandelate is 456-59-7.

What is the molecular formula and weight of Cyclandelate?

The molecular formula of Cyclandelate is C17H24O3 and its molar mass is 276.38 g/mol.

What is Cyclandelate used for?

Known uses and roles of Cyclandelate include cardiovascular drugs in pharmaceuticals, cardiovascular drug, pharmaceutical, vasodilator agent and vasodilator agents.

Is Cyclandelate hazardous?

Cyclandelate carries the GHS signal word "Warning". Main hazards: causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cyclandelate?

Cyclandelate is usually classified under HS code 291819 (Carboxylic acids with alcohol function but without other oxygen function, their…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cyclandelate?

CompoundList lists 6 suppliers of Cyclandelate in United States, China and Germany. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Cyclandelate?

Suppliers quote Cyclandelate on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cyclandelate

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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