CompoundList
Sign in
Fungicides

Cycloheximide

Also known as Actidione, Cicloheximide, Naramycin a

CAS 66-81-9Formula C15H23NO4Molar mass 281.35 g/molEC 200-636-0
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Serious health hazard, Hazardous to the environment 71 suppliers listed
Get quotes Compare 71 suppliers
Cycloheximide chemical structure, C15H23NO4, CAS 66-81-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Plates from amyl acetate, water or 30% methanol
Melting point
119.5 to 121
Solubility
At 2 °C (g/100 ml): water 2.1, amyl acetate 7, sol in chloroform, ether, methanol, ethan…
HS code
292519
Category
Fungicides
UN number
UN 2588
Illustrative photo, closed white HDPE bottles and amber jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Cycloheximide?

Plain description, key identifiers and synonyms

Cycloheximide is a dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus. It has a role as an anticoronaviral agent, a ferroptosis inhibitor, a protein synthesis inhibitor, a neuroprotective agent and a bacterial metabolite. It is a dicarboximide, a secondary alcohol, a cyclic ketone, a member of piperidones, a piperidine antibiotic and an antibiotic fungicide. It is functionally related to a piperidine-2,6-dione.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
CAS number
66-81-9 CAS number cross-checkedOther or deprecated CAS: 1154-57-0, 4630-75-5
EC number
200-636-0
Molecular formula
C15H23NO4
UNII
98600C0908
MDL number
MFCD00082346
InChIKey
YPHMISFOHDHNIV-FSZOTQKASA-N
InChI
InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
Canonical SMILES
CC1CC(C)C(=O)C(C(O)CC2CC(=O)NC(=O)C2)C1
Isomeric SMILES
C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C

Synonyms

  • Actidione
  • Cicloheximide
  • Naramycin a
  • Actidion
  • Hizarocin
  • Naramycin
  • Kaken
  • Acti-Aid
  • Actidone
  • Neocycloheximide
  • Cicloheximida
  • Actispray
  • Actidione PM
  • Cicloheximidum
  • Actidione BR
  • Actidione TGF
  • Aktidion
  • 4-[(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
  • (-)-Cycloheximide
  • NM-MCD 80
  • CBC 500046
  • 3-((R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide
  • 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione
  • 3-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide
  • beta-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide
Show all 35 synonyms
  • 2,6-Piperidinedione, 4-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (1S-(1alpha(S*),3alpha,5beta))-
  • 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide
  • 2,6-Piperidinedione, 4-((2R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-
  • 2,6-Piperidinedione, 4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-
  • 3-[(R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]glutarimide
  • 4-((2R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)piperidine-2,6-dione
  • Acti-Dione
  • Cycloheximid
  • Zykloheximid
  • Acti-dione BR

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Plates from amyl acetate, water or 30% methanolexp.
Melting point
119.5 to 121exp.
Solubility
At 2 °C (g/100 ml): water 2.1, amyl acetate 7, sol in chloroform, ether, methanol, ethanol, insol in saturated hydrocarbonsexp.
Vapour pressure
0.006 [mm Hg] @25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
281.35 g/molcalc.
Exact mass
281.1627 Dacalc.
LogP (octanol/water)
1.04calc.
Topological polar surface area
83.47 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
20calc.
Rings
2calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.8calc.
Formal charge
0calc.
Stereocentres
4calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CC(CCC2CCCCC2=O)CC(=O)N1

O=C1CC(CCC2CCCCC2=O)CC(=O)N1

2 rings, 17 atoms.

9 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H300Fatal if swallowed.
  • H341Suspected of causing genetic defects.
  • H360DMay damage the unborn child.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (12)
  • P203Obtain, read and follow all safety instructions before use.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P391Collect spillage.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2588
Transport hazard class
6.1
Packing group
I

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Cycloheximide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 71 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

71 suppliers in 14 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Cycloheximide price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Fungicide, plant growth regulator, as protein synthesis inhibitor.

/Cycloheximide/ is used in laboratory media as a selective agent to permit isolation of pathogenic and non-pathogenic fungi from specimens such as sputa and feces which may be other fungi.

Cycloheximide has a limited application in treatment of downy mildew of onions and shoot blight of Japanese larch.

Pharmacological actions

  • Antifungal Agents
  • Protein Synthesis Inhibitors

Roles

  • anticoronaviral agent
  • antimicrobial agent
  • antiviral agent
  • bacterial metabolite
  • enzyme inhibitor
  • ferroptosis inhibitor
  • metabolite
  • neuroprotective agent
  • pathway inhibitor
  • pharmaceutical
  • prokaryotic metabolite
  • protective agent
  • protein synthesis inhibitor

How it is made

Antibiotic substance isolated from beers of streptomycin-producing strains of Streptomyces griseus: Leach et al, J Am Chem Soc 69, 474 (1947), Ford, Leach, J Am Chem Soc 70, 1223 (1948), Whiffen et al, US patent 2,574,519 (1951 to Upjohn). Production, assay and antibiotic activity: Whiffen, J Bacteriol 56, 283 (1948). Improved production method: Kominek, US patents 3,915,802-3 (both 1975 to Upjohn). ... synthesis of dl- and l-forms: Johnson et al, J Am Chem Soc 88, 149 (1966).

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 613-140-00-8

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Cycloheximide, Ref no: 729, Annex ref: II/729

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Cycloheximide is traded under.

HS 2925.19Indicative HS code

Imides and their derivatives, salts thereof, other

World exports in 2024
$295M
+11.7% vs 2023, imports $348M
2019 to 2024
Top exporters
  1. China29.7%
  2. Japan22.7%
  3. United Kingdom10.0%
Top importers
  1. United States12.7%
  2. Brazil12.6%
  3. China10.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Cycloheximide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Cycloheximide, based on the data on this page

What is Cycloheximide?

Cycloheximide is a dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.

What is the CAS number of Cycloheximide?

The CAS registry number of Cycloheximide is 66-81-9. Other or deprecated CAS numbers: 1154-57-0, 4630-75-5.

What is the molecular formula and weight of Cycloheximide?

The molecular formula of Cycloheximide is C15H23NO4 and its molar mass is 281.35 g/mol.

What is Cycloheximide used for?

Fungicide, plant growth regulator, as protein synthesis inhibitor. /Cycloheximide/ is used in laboratory media as a selective agent to permit isolation of pathogenic and non-pathogenic fungi from specimens such as sputa and feces which may be other fungi.

Is Cycloheximide hazardous?

Cycloheximide carries the GHS signal word "Danger". Main hazards: fatal if swallowed, suspected of causing genetic defects, may damage the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Cycloheximide?

Cycloheximide is usually classified under HS code 292519 (Imides and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Cycloheximide?

CompoundList lists 71 suppliers of Cycloheximide in United States, China, India, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Cycloheximide in India?

6 suppliers in India list Cycloheximide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Cycloheximide?

Suppliers quote Cycloheximide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Cycloheximide

Get quotes for Cycloheximide

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Cycloheximide
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Cycloheximide with a 3D view, its CAS number and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/cycloheximide-66-81-9" title="Cycloheximide structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Fungicides or HS code 292519

71 suppliers
Free quotes, contact stays private
Get quotes