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Oncology and immunology drugs

Dacarbazine

Also known as DTIC, DTIC-Dome, Deticene

CAS 4342-03-4Formula C6H10N6OMolar mass 182.19 g/molEC 224-396-1
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 73 suppliers listed Drug substance
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Dacarbazine chemical structure, C6H10N6O, CAS 4342-03-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Ivory microcrystaline substance
Melting point
205 °C
Solubility
Water: (1 mg/ml at room temp)
HS code
293329
Category
Oncology and immunology drugs

What is Dacarbazine?

Plain description, key identifiers and synonyms

(E)-dacarbazine is a dacarbazine in which the N=N double bond adopts a trans-configuration.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[(E)-dimethylaminodiazenyl]-1H-imidazole-5-carboxamide
CAS number
4342-03-4 CAS number cross-checkedOther or deprecated CAS: 94361-71-4
EC number
224-396-1
Molecular formula
C6H10N6O
UNII
7GR28W0FJI
MDL number
MFCD00057167
InChIKey
FDKXTQMXEQVLRF-ZHACJKMWSA-N
InChI
InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
Canonical SMILES
CN(C)N=Nc1nc[nH]c1C(N)=O
Isomeric SMILES
CN(C)/N=N/C1=C(NC=N1)C(=O)N

Synonyms

  • DTIC
  • DTIC-Dome
  • Deticene
  • Biocarbazine R
  • Decarbazine
  • ICDMT
  • ICDT
  • Dacarbazinum
  • Imidazole carboxamide
  • Dacarbasine
  • Dicarbazine
  • 4-(Dimethyltriazeno)imidazole-5-carboxamide
  • 5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide
  • 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
  • Di-me-triazenoimidazolecarboxamide
  • (Dimethyltriazeno)imidazolecarboxamide
  • 5-(Dimethyltriazeno)imidazole-4-carboxamide
  • dacarbazina
  • 4-(3,3-Dimethyl-1-triazeno)imidazole-5-carboxamide
  • 4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide
  • 1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-
  • Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazeno)-
  • 4-(or 5)-(3,3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide
  • Carboxamide, Dimethyl Imidazole
  • 5-(dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide
Show all 38 synonyms
  • Dacatic
  • DTICDome
  • Dakarbazin
  • DTIC Dome
  • (5Z)-5-(dimethylaminohydrazono)imidazole-4-carboxamide
  • Dimethyl Triazeno Imidazole Carboxamide
  • Imidazole Carboxamide, Dimethyl
  • Asercit
  • Detimedac
  • Fauldetic
  • Dacarbazine-DTIC
  • Dacarbazina Almirall
  • 5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Ivory microcrystaline substanceexp.
Melting point
205 °Cexp.
Solubility
Water: (1 mg/ml at room temp)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
182.19 g/molcalc.
Exact mass
182.0916 Dacalc.
LogP (octanol/water)
0.07calc.
Topological polar surface area
99.73 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
3calc.
Heavy atoms
13calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.33calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1c[nH]cn1

c1c[nH]cn1

1 ring, 5 atoms, the Imidazole ring system.

14,448 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302 + H312 + H332Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.
  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H332Harmful if inhaled.
  • H335May cause respiratory irritation.
  • H340May cause genetic defects.
  • H350May cause cancer.
Precautionary statements (22)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dacarbazine suppliers

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All 73 suppliers
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Where suppliers are based

73 suppliers in 15 countries

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Dacarbazine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Antineoplastic Agents, Alkylating

Roles

  • aetiopathogenetic role
  • alkylating agent
  • antineoplastic agent
  • carcinogenic agent
  • genotoxin
  • mutagen
  • pharmaceutical
  • pro-agent
  • prodrug

Pharmacology

Dacarbazine is an Alkylating Drug. The mechanism of action of dacarbazine is as an Alkylating Activity.

How it is made

5-Aminoimidazole-4-carboxamide was treated with a 20% excess of sodium nitrite to give 5-diazoimidazole-4-carboxamide, which was treated with anhydrous dimethylamine in methanol to give dacarbazine. It is not known whether this is the process used for its commercial production.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dacarbazine is traded under.

HS 2933.29Indicative HS code

Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…

World exports in 2024
$1.43B
−7.6% vs 2023, imports $1.47B
2019 to 2024
Top exporters
  1. China28.1%
  2. France * partner reported12.7%
  3. India * partner reported10.3%
Top importers
  1. United Kingdom13.0%
  2. United States7.9%
  3. China6.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dacarbazine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dacarbazine, based on the data on this page

What is Dacarbazine?

(E)-dacarbazine is a dacarbazine in which the N=N double bond adopts a trans-configuration.

What is the CAS number of Dacarbazine?

The CAS registry number of Dacarbazine is 4342-03-4. Other or deprecated CAS numbers: 94361-71-4.

What is the molecular formula and weight of Dacarbazine?

The molecular formula of Dacarbazine is C6H10N6O and its molar mass is 182.19 g/mol.

What is Dacarbazine used for?

Known uses and roles of Dacarbazine include anticancer drugs in pharmaceuticals, aetiopathogenetic role, alkylating agent, antineoplastic agent, carcinogenic agent and 6 more.

Is Dacarbazine hazardous?

Dacarbazine carries the GHS signal word "Danger". Main hazards: harmful if swallowed. harmful in contact with skin. harmful if inhaled, harmful if swallowed, harmful in contact with skin. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dacarbazine?

Dacarbazine is usually classified under HS code 293329 (Compounds containing an unfused imidazole ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dacarbazine?

CompoundList lists 73 suppliers of Dacarbazine in United States, China, India, Germany and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Dacarbazine in India?

12 suppliers in India list Dacarbazine on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Dacarbazine?

Suppliers quote Dacarbazine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dacarbazine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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