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Daprodustat

Also known as Jesduvroq, Duvroq, daprodustatum

CAS 960539-70-2Formula C19H27N3O6Molar mass 393.44 g/molEC 691-659-9
GHS signal word: Warning. Pictograms: Harmful or irritant, Hazardous to the environment 27 suppliers listed Drug substance
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Daprodustat chemical structure, C19H27N3O6, CAS 960539-70-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
960539-70-2
Formula
C19H27N3O6
Molar mass
393.44 g/mol
EC number
691-659-9
HS code
293359
Category
Pharmaceuticals and APIs

What is Daprodustat?

Plain description, key identifiers and synonyms

Daprodustat is a member of the class of barbiturates that is barbituric acid substituted by cyclohexyl groups at positions 1 and 3, and by a (carboxymethyl)aminocarbonyl group at position 5. It is an inhibitor of hypoxia-inducible factor prolyl hydroxylase developed by GlaxoSmithKline for the treatment of anaemia in patients with chronic kidney disease. It has a role as an EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor, an antiviral agent and an anti-anaemic agent. It is a secondary carboxamide, a N-acylglycine, a member of barbiturates and an oxo monocarboxylic acid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid
CAS number
960539-70-2
EC number
691-659-9
Molecular formula
C19H27N3O6
UNII
JVR38ZM64B
MDL number
MFCD29924726
InChIKey
RUEYEZADQJCKGV-UHFFFAOYSA-N
InChI
InChI=1S/C19H27N3O6/c23-14(24)11-20-16(25)15-17(26)21(12-7-3-1-4-8-12)19(28)22(18(15)27)13-9-5-2-6-10-13/h12-13,15H,1-11H2,(H,20,25)(H,23,24)
SMILES (canonical and isomeric)
C1CCC(CC1)N2C(=O)C(C(=O)N(C2=O)C3CCCCC3)C(=O)NCC(=O)O

Synonyms

  • Jesduvroq
  • Duvroq
  • daprodustatum
  • N-((1,3-Dicyclohexylhexahydro-2,4,6-trioxopyrimidin-5-yl)carbonyl)glycine
  • 2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid
  • 2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinan-5-yl)formamido]acetic acid
  • Glycine, N-((1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl)-
  • N-[(1,3-Dicyclohexylhexahydro-2,4,6-trioxopyrimidin-5-yl)carbonyl]glycine
  • 2-((1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinan-5-yl)formamido)acetic acid
  • 2-((1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino)acetic acid
  • Glycine, N-[(1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]-
  • GSK 1278863
  • Daprodustat (GSK1278863)
  • (1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine
  • Daprodustat?
  • Jesduvroq (TN)
  • Duvroq (TN)
  • Daprodustat (Standard)
  • Daprodustat, GSK1278863
  • Daprodustat (JAN/USAN/INN)
  • N-[(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)carbonyl]glycine
  • {[(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidin-5-yl)carbonyl]amino}acetic acid
  • 2-(1,3-Dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carboxamido)acetic acid
  • 2-[(1,3-dicyclohexyl-2,4,6-trioxo-hexahydropyrimidine-5-carbonyl)amino]acetic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
393.44 g/molcalc.
Exact mass
393.19 Dacalc.
LogP (octanol/water)
1.26calc.
Topological polar surface area
124.1 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
5calc.
Heavy atoms
28calc.
Rings
3calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.74calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CC(=O)N(C2CCCCC2)C(=O)N1C1CCCCC1

O=C1CC(=O)N(C2CCCCC2)C(=O)N1C1CCCCC1

3 rings, 21 atoms, the 1,3-Dicyclohexyl-2,4,6(1H,3H,5H)-pyrimidinetrione ring system.

19 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (7)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Daprodustat suppliers

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All 27 suppliers
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Where suppliers are based

27 suppliers in 7 countries

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Daprodustat price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • anti-anaemic agent
  • antimicrobial agent
  • antiviral agent
  • enzyme inhibitor
  • pharmaceutical
  • vulnerary

Pharmacology

Daprodustat is a Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor. The mechanism of action of daprodustat is as a Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Daprodustat is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Daprodustat is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Daprodustat, based on the data on this page

What is Daprodustat?

Daprodustat is a member of the class of barbiturates that is barbituric acid substituted by cyclohexyl groups at positions 1 and 3, and by a (carboxymethyl)aminocarbonyl group at position 5.

What is the CAS number of Daprodustat?

The CAS registry number of Daprodustat is 960539-70-2.

What is the molecular formula and weight of Daprodustat?

The molecular formula of Daprodustat is C19H27N3O6 and its molar mass is 393.44 g/mol.

What is Daprodustat used for?

Known uses and roles of Daprodustat include anti-anaemic agent, antimicrobial agent, antiviral agent, enzyme inhibitor, pharmaceutical and 1 more.

Is Daprodustat hazardous?

Daprodustat carries the GHS signal word "Warning". Main hazards: harmful if swallowed, toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Daprodustat?

Daprodustat is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Daprodustat?

CompoundList lists 27 suppliers of Daprodustat in China, United States, India, Canada and 3 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Daprodustat in India?

3 suppliers in India list Daprodustat on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Daprodustat?

Suppliers quote Daprodustat on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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