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Antibiotics and anti-infectives

Daptomycin

Also known as Cidecin, Cubicin, Daptomycinum

CAS 103060-53-3Formula C72H101N17O26Molar mass 1,620.69 g/molEC 600-389-2
GHS signal word: Warning. Pictograms: Serious health hazard 84 suppliers listed Drug substance
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Daptomycin chemical structure, C72H101N17O26, CAS 103060-53-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
103060-53-3
Formula
C72H101N17O26
Molar mass
1,620.69 g/mol
EC number
600-389-2
HS code
294190
Category
Antibiotics and anti-infectives

What is Daptomycin?

Plain description, key identifiers and synonyms

Daptomycin is a semi-synthetic cyclic lipopeptide antibiotic isolated form the bacterium Streptomyces roseosporus with broad-spectrum antibiotic activity against Gram-positive bacteria. Daptomycin has a distinct mechanism of action, in which it binds to bacterial membrane and causes rapid depolarization of the cell membrane due to calcium-dependant potassium efflux, the loss of membrane potential leads to inhibition of DNA, RNA and protein synthesis, resulting in bacterial cell death. This agent does not penetrate the outer membrane of gram-negative bacteria.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3S)-3-[[(2R)-4-amino-2-[[(2S)-2-(decanoylamino)-3-(1H-indol-3-yl)propanoyl]amino]-4-oxobutanoyl]amino]-4-[[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonazacyclohentriacont-30-yl]amino]-4-oxobutanoic acid
CAS number
103060-53-3 CAS number cross-checked
EC number
600-389-2
Molecular formula
C72H101N17O26
UNII
NWQ5N31VKK
MDL number
MFCD08282794
InChIKey
DOAKLVKFURWEDJ-QCMAZARJSA-N
InChI
InChI=1S/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)/t35-,36-,37-,43+,44+,45-,46+,47+,48+,49+,50-,60+,61+/m1/s1
Canonical SMILES
CCCCCCCCCC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(N)=O)C(=O)NC(CC(=O)O)C(=O)NC1C(=O)NCC(=O)NC(CCCN)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)NCC(=O)NC(CO)C(=O)NC(C(C)CC(=O)O)C(=O)NC(CC(=O)c2ccccc2N)C(=O)OC1C
Isomeric SMILES
CCCCCCCCCC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H]3[C@H](OC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC3=O)CCCN)CC(=O)O)C)CC(=O)O)CO)[C@H](C)CC(=O)O)CC(=O)C4=CC=CC=C4N)C

Synonyms

  • Cidecin
  • Cubicin
  • Daptomycinum
  • Dapcin
  • Daptomycine
  • Cubicin Rf
  • Dapzura rt
  • LY 146032
  • Daptomycin in Sodium Chloride
  • Daptomycin, 9 L beta Aspartic Acid
  • Daptomycin in 0.9% sodium chloride
  • Daptomicina
  • Daptomycin for injection
  • (2R)-daptomycin
  • Cubicin (TN)
  • Daptomycin (Standard)
  • Daptomycin (JAN/USAN/INN)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
1,620.69 g/molcalc.
Exact mass
1,619.7104 Dacalc.
LogP (octanol/water)
-5.62calc.
Topological polar surface area
702 Ųcalc.
Hydrogen bond donors
22calc.
Hydrogen bond acceptors
24calc.
Rotatable bonds
35calc.
Heavy atoms
115calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.53calc.
Formal charge
0calc.
Stereocentres
13calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CCc1c[nH]c2ccccc12)NCC(=O)NCC(=O)NC1COC(=O)C(CC(=O)c2ccccc2)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC1=O

O=C(CCc1c[nH]c2ccccc12)NCC(=O)NCC(=O)NC1COC(=O)C(CC(=O)c2ccccc2)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC1=O

4 rings, 72 atoms.

12 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (3)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P319Get medical help if you feel unwell.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Daptomycin suppliers

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All 84 suppliers
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Where suppliers are based

84 suppliers in 18 countries

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Daptomycin price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Bacterial Agents

Roles

  • antibacterial agent
  • antibacterial drug
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • bacterial metabolite
  • calcium-dependent antibiotics
  • metabolite
  • pharmaceutical
  • prokaryotic metabolite

Pharmacology

Daptomycin is a Lipopeptide Antibacterial.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Daptomycin is traded under.

HS 2941.90Indicative HS code

Antibiotics, other

World exports in 2024
$6.39B
+2.3% vs 2023, imports $6.97B
2019 to 2024
Top exporters
  1. China39.7%
  2. United States11.3%
  3. Switzerland * partner reported10.9%
Top importers
  1. Italy15.0%
  2. India * partner reported12.0%
  3. China8.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Daptomycin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Daptomycin, based on the data on this page

What is Daptomycin?

Daptomycin is a semi-synthetic cyclic lipopeptide antibiotic isolated form the bacterium Streptomyces roseosporus with broad-spectrum antibiotic activity against Gram-positive bacteria.

What is the CAS number of Daptomycin?

The CAS registry number of Daptomycin is 103060-53-3.

What is the molecular formula and weight of Daptomycin?

The molecular formula of Daptomycin is C72H101N17O26 and its molar mass is 1,620.69 g/mol.

What is Daptomycin used for?

Known uses and roles of Daptomycin include antibacterials and antibiotics in pharmaceuticals, antibacterial agent, antibacterial drug, antiinfective agent, antimicrobial agent and 7 more.

Is Daptomycin hazardous?

Daptomycin carries the GHS signal word "Warning". Main hazards: may cause damage to organs through prolonged or repeated exposure. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Daptomycin?

Daptomycin is usually classified under HS code 294190 (Antibiotics, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Daptomycin?

CompoundList lists 84 suppliers of Daptomycin in China, United States, India, Italy and 14 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Daptomycin in India?

5 suppliers in India list Daptomycin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Daptomycin?

Suppliers quote Daptomycin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Daptomycin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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