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Rodenticides, nematicides and other pesticides

Dicoumarol

Also known as dicumarol, Bishydroxycoumarin, melitoxin

CAS 66-76-2Formula C19H12O6Molar mass 336.30 g/molEC 200-632-9
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard, Hazardous to the environment 69 suppliers listed
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Dicoumarol chemical structure, C19H12O6, CAS 66-76-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White or creamy white, crystalline powder
Melting point
287 to 293
Solubility
Practically insol in water, alc, ether.
HS code
293220
Category
Rodenticides, nematicides and other pesticides
Illustrative photo, off-white powder in an open kraft paper sack in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Dicoumarol?

Plain description, key identifiers and synonyms

Dicoumarol is a hydroxycoumarin that is methane in which two hydrogens have each been substituted by a 4-hydroxycoumarin-3-yl group. Related to warfarin, it has been used as an anticoagulant. It has a role as an anticoagulant, an EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor, a vitamin K antagonist and a Hsp90 inhibitor.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-hydroxy-3-[(4-hydroxy-2-oxochromen-3-yl)methyl]chromen-2-one
CAS number
66-76-2 CAS number cross-checked
EC number
200-632-9
Molecular formula
C19H12O6
UNII
7QID3E7BG7
MDL number
MFCD00006857
InChIKey
DOBMPNYZJYQDGZ-UHFFFAOYSA-N
InChI
InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2
SMILES (canonical and isomeric)
C1=CC=C2C(=C1)C(=C(C(=O)O2)CC3=C(C4=CC=CC=C4OC3=O)O)O

Synonyms

  • dicumarol
  • Bishydroxycoumarin
  • melitoxin
  • Antitrombosin
  • Baracoumin
  • Dicumarine
  • Acadyl
  • Acavyl
  • Dicuman
  • Dicumol
  • Dicoumal
  • Dufalone
  • Kumoran
  • Temparin
  • Trombosan
  • Cumid
  • Cuma
  • bis-hydroxycoumarin
  • Dicumaol R
  • Dicoumarolum
  • 3,3'-Methylenebis(4-hydroxycoumarin)
  • Anathrombase
  • Apekumarol
  • Dicoumerol
  • Dicumarinum
Show all 39 synonyms
  • Dicumarolum
  • Bis(4-hydroxycoumarin-3-yl)methane
  • Bis-3,3'-(4-hydroxycoumarinyl)methane
  • Di-(4-hydroxy-3-coumarinyl)methane
  • Dicumarolo
  • Dwukumarol
  • Di-4-hydroxy-3,3'-methylenedicoumarin
  • 3,3'-Methylen-bis(4-hydroxy-cumarin)
  • 3,3'-Methylene-bis(4-hydroxycoumarine)
  • 3,3'-Methylenebis(4-hydroxy-1,2-benzopyrone)
  • 3,3'-Methylenebis(4-hydroxy-2H-1-benzopyran-2-one)
  • NC 034
  • 3,3'-Metilen-bis(4-idrossi-cumarina)
  • 3,3'-Methyleen-bis(4-hydroxy-cumarine)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White or creamy white, crystalline powderexp.
Odour
Slight, pleasant odorexp.
Taste
Slightly bitter tasteexp.
Melting point
287 to 293exp.
Solubility
Practically insol in water, alc, ether.exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
336.30 g/molcalc.
Exact mass
336.0634 Dacalc.
LogP (octanol/water)
2.9calc.
Topological polar surface area
100.9 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
2calc.
Heavy atoms
25calc.
Rings
4calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.05calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1oc2ccccc2cc1Cc1cc2ccccc2oc1=O

O=c1oc2ccccc2cc1Cc1cc2ccccc2oc1=O

4 rings, 23 atoms, the 3,3'-Methylenebis(2H-1-benzopyran-2-one) ring system.

21 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard
GHS09: Hazardous to the environment
Hazardous to the environment

Hazard statements

  • H302Harmful if swallowed.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H411Toxic to aquatic life with long lasting effects.
Precautionary statements (9)
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P301 + P317If swallowed: Get medical help.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P391Collect spillage.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Dicoumarol suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 69 suppliers
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Where suppliers are based

69 suppliers in 14 countries

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Dicoumarol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Rodenticide.

The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies discontinued drug products. Dicumarol is included on this list.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anticoagulants
  • Enzyme Inhibitors
  • Uncoupling Agents

Roles

  • Hsp90 inhibitor
  • antagonist
  • anticoagulant
  • enzyme inhibitor
  • hematologic agent
  • pharmaceutical
  • vitamin K antagonist

Pharmacology

Dicumarol is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicumarol is a competitive inhibitor of vitamin K epoxide reductase, thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.

How it is made

Originally isolated from spoiled sweet clover (improperly cured Melilotus hay) ... now prepared synthetically by the action of formaldehyde on 4-hydroxy-coumarin (obtained as the Na derivative by the action of sodium metal on methyl acetylsalicylate)...

Regulatory status

Inventories, regulations and trade controls that list this substance

Europe

  • EU harmonised classification (CLP Annex VI)
    Index no: 607-060-00-2

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Dicoumarol (INN), Ref no: 231, Annex ref: II/231

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Dicoumarol is traded under.

HS 2932.20Indicative HS code

Lactones

World exports in 2024
$1.97B
−4.7% vs 2023, imports $2.07B
2019 to 2024
Top exporters
  1. China56.3%
  2. India * partner reported7.4%
  3. Germany7.3%
Top importers
  1. United States14.2%
  2. India * partner reported13.5%
  3. Brazil8.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Dicoumarol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Dicoumarol, based on the data on this page

What is Dicoumarol?

Dicoumarol is a hydroxycoumarin that is methane in which two hydrogens have each been substituted by a 4-hydroxycoumarin-3-yl group. Related to warfarin, it has been used as an anticoagulant.

What is the CAS number of Dicoumarol?

The CAS registry number of Dicoumarol is 66-76-2.

What is the molecular formula and weight of Dicoumarol?

The molecular formula of Dicoumarol is C19H12O6 and its molar mass is 336.30 g/mol.

What is Dicoumarol used for?

Rodenticide. The Approved Drug Products with Therapeutic Equivalence Evaluations List identifies discontinued drug products. Dicumarol is included on this list. Use classes: Pharmaceuticals.

Is Dicoumarol hazardous?

Dicoumarol carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes damage to organs through prolonged or repeated exposure, toxic to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Dicoumarol?

Dicoumarol is usually classified under HS code 293220 (Lactones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Dicoumarol?

CompoundList lists 69 suppliers of Dicoumarol in United States, China, United Kingdom, Germany and 10 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Dicoumarol?

Suppliers quote Dicoumarol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Dicoumarol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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