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Cosmetic antioxidants

Diosmin

Also known as Barosmin, Venosmine, Diosmine

CAS 520-27-4Formula C28H32O15Molar mass 608.55 g/molEC 208-289-7
127 suppliers listed Drug substance
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Diosmin chemical structure, C28H32O15, CAS 520-27-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
520-27-4
Formula
C28H32O15
Molar mass
608.55 g/mol
EC number
208-289-7
HS code
293890
Category
Cosmetic antioxidants

What is Diosmin?

Plain description, key identifiers and synonyms

Diosmin is a disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and an anti-inflammatory agent. It is a monomethoxyflavone, a rutinoside, a dihydroxyflavanone, a glycosyloxyflavone and a disaccharide derivative. It is functionally related to a diosmetin.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
CAS number
520-27-4 CAS number cross-checked
EC number
208-289-7
Molecular formula
C28H32O15
UNII
7QM776WJ5N
MDL number
MFCD00009772
INCI name
DIOSMINE
InChIKey
GZSOSUNBTXMUFQ-YFAPSIMESA-N
InChI
InChI=1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1
Canonical SMILES
COc1ccc(-c2cc(=O)c3c(O)cc(OC4OC(COC5OC(C)C(O)C(O)C5O)C(O)C(O)C4O)cc3o2)cc1O
Isomeric SMILES
C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)OC3=CC(=C4C(=C3)OC(=CC4=O)C5=CC(=C(C=C5)OC)O)O)O)O)O)O)O)O

Synonyms

  • Barosmin
  • Venosmine
  • Diosmine
  • Flebosten
  • Tovene
  • Ven-Detrex
  • Diovenor
  • Buchu Resin
  • Litosmil
  • flebosmil
  • Diosminum
  • Flebavena
  • Diosmetin 7-O-rutinoside
  • Diosven
  • Flebaven
  • Hemerven
  • Insuven
  • Varinon
  • Dioven
  • Diosmina
  • 3',5,7-trihydroxy-4'-methoxyflavone-7-rutinoside
  • 3',5,7-trihydroxy-4'-methoxyflavone 7-rhamnoglucoside
  • 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-
  • diosmiplex
  • Vasculera
Show all 36 synonyms
  • Resin, Buchu
  • Diosimin
  • Diosmil
  • Veno-V
  • Diosmetin-7-O-rutinoside
  • Rioven
  • Diosmin (INN)
  • Diosmin (mart.)
  • Diosmin, analytical standard
  • 4H-1-Benzopyran-4-one,7-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-
  • 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-1-benzopyran-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
608.55 g/molcalc.
Exact mass
608.1741 Dacalc.
LogP (octanol/water)
-1.09calc.
Topological polar surface area
238.2 ร…ยฒcalc.
Hydrogen bond donors
8calc.
Hydrogen bond acceptors
15calc.
Rotatable bonds
7calc.
Heavy atoms
43calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.46calc.
Formal charge
0calc.
Stereocentres
10calc.
Lipinski rule of five
Fails (3 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=c1cc(-c2ccccc2)oc2cc(OC3CCCC(COC4CCCCO4)O3)ccc12

O=c1cc(-c2ccccc2)oc2cc(OC3CCCC(COC4CCCCO4)O3)ccc12

5 rings, 32 atoms.

40 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Diosmin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 127 suppliers
30 of 30 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

127 suppliers in 19 countries

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Diosmin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Cosmetics.

Cosmetic ingredient, INCI name DIOSMINE(antioxidant)

Roles

  • anti-inflammatory agent
  • anti-ulcer drug
  • antioxidant
  • antirheumatic drug
  • cardiovascular drug
  • pharmaceutical

Functional uses

  • Antioxidant

Cosmetic functions

  • Antioxidant

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Diosmin is traded under.

HS 2938.90Indicative HS code

Natural or reproduced by synthesis, other than rutoside (rutin) and its derivatives

World exports in 2024
$1.4B
โˆ’8.3% vs 2023, imports $1.35B
2019 to 2024
Top exporters
  1. China49.2%
  2. France * partner reported8.9%
  3. Malaysia6.1%
Top importers
  1. United States22.3%
  2. India * partner reported7.8%
  3. Brazil5.5%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Diosmin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Diosmin, based on the data on this page

What is Diosmin?

Diosmin is a disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and an anti-inflammatory agent.

What is the CAS number of Diosmin?

The CAS registry number of Diosmin is 520-27-4.

What is the molecular formula and weight of Diosmin?

The molecular formula of Diosmin is C28H32O15 and its molar mass is 608.55 g/mol.

What is Diosmin used for?

Use classes: Cosmetics.

Is Diosmin hazardous?

No GHS hazard classification for Diosmin is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Diosmin?

Diosmin is usually classified under HS code 293890 (Glycosides, natural or reproduced by synthesis, and their salts, ethers, esters andโ€ฆ). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Diosmin?

CompoundList lists 127 suppliers of Diosmin in China, United States, India, Spain and 15 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Diosmin in India?

8 suppliers in India list Diosmin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Diosmin?

Suppliers quote Diosmin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Diosmin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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