CompoundList
Sign in
Screening compounds

Divarasib

Also known as Gdc 6036, KRAS G12C Inhibitor GDC-6036, US11236068, Example 17a

CAS 2417987-45-0Formula C29H32ClF4N7O2Molar mass 622.07 g/mol
2 suppliers listed
Get quotes Compare 2 suppliers
Divarasib chemical structure, C29H32ClF4N7O2, CAS 2417987-45-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2417987-45-0
Formula
C29H32ClF4N7O2
Molar mass
622.07 g/mol
HS code
293359
Category
Screening compounds

What is Divarasib?

Plain description, key identifiers and synonyms

Divarasib is an orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon oral administration, divarasib selectively targets the KRAS G12C mutant and inhibits KRAS G12C mutant-dependent signaling. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[(3S)-4-[7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]quinazolin-4-yl]-3-methylpiperazin-1-yl]prop-2-en-1-one
CAS number
2417987-45-0Other or deprecated CAS: 2417917-17-8
Molecular formula
C29H32ClF4N7O2
UNII
E6S21PVT91
InChIKey
ZRBPIAWWRPFDPY-IRXDYDNUSA-N
InChI
InChI=1S/C29H32ClF4N7O2/c1-5-21(42)40-9-10-41(16(3)13-40)27-18-12-19(30)22(26-23(29(32,33)34)15(2)11-20(35)36-26)24(31)25(18)37-28(38-27)43-14-17-7-6-8-39(17)4/h5,11-12,16-17H,1,6-10,13-14H2,2-4H3,(H2,35,36)/t16-,17-/m0/s1
Canonical SMILES
C=CC(=O)N1CCN(c2nc(OCC3CCCN3C)nc3c(F)c(-c4nc(N)cc(C)c4C(F)(F)F)c(Cl)cc23)C(C)C1
Isomeric SMILES
C[C@H]1CN(CCN1C2=NC(=NC3=C(C(=C(C=C32)Cl)C4=C(C(=CC(=N4)N)C)C(F)(F)F)F)OC[C@@H]5CCCN5C)C(=O)C=C

Synonyms

  • Gdc 6036
  • KRAS G12C Inhibitor GDC-6036
  • US11236068, Example 17a
  • US11236068, Example 17b
  • compound 10
  • GDC-6036, GDC 6036, GDC6036, RG6330, RG-6330, RG 6330

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
622.07 g/molcalc.
Exact mass
621.2242 Dacalc.
LogP (octanol/water)
5.09calc.
Topological polar surface area
100.7 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
8calc.
Rotatable bonds
6calc.
Heavy atoms
43calc.
Rings
5calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.45calc.
Formal charge
0calc.
Stereocentres
2calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(-c2ccc3c(N4CCNCC4)nc(OCC4CCCN4)nc3c2)nc1

c1ccc(-c2ccc3c(N4CCNCC4)nc(OCC4CCCN4)nc3c2)nc1

5 rings, 29 atoms.

3 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Divarasib suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 2 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 1 country

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Divarasib price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Divarasib is traded under.

HS 2933.59Indicative HS code

Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring, other

World exports in 2024
$18.4B
+10.5% vs 2023, imports $24.8B
2019 to 2024
Top exporters
  1. Ireland43.6%
  2. Switzerland * partner reported26.3%
  3. China7.9%
Top importers
  1. Slovenia30.3%
  2. United States30.1%
  3. Germany15.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Divarasib is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Divarasib, based on the data on this page

What is Divarasib?

Divarasib is an orally available inhibitor of the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon oral administration, divarasib selectively targets the KRAS G12C mutant and inhibits KRAS G12C mutant-dependent signaling.

What is the CAS number of Divarasib?

The CAS registry number of Divarasib is 2417987-45-0. Other or deprecated CAS numbers: 2417917-17-8.

What is the molecular formula and weight of Divarasib?

The molecular formula of Divarasib is C29H32ClF4N7O2 and its molar mass is 622.07 g/mol.

What is Divarasib used for?

Known uses and roles of Divarasib include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Divarasib hazardous?

No GHS hazard classification for Divarasib is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Divarasib?

Divarasib is usually classified under HS code 293359 (Compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Divarasib?

CompoundList lists 2 suppliers of Divarasib in United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Divarasib?

Suppliers quote Divarasib on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Divarasib

Get quotes for Divarasib

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Divarasib
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Divarasib with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/divarasib-2417987-45-0" title="Divarasib structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Screening compounds or HS code 293359

2 suppliers
Free quotes, contact stays private
Get quotes