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Analgesics and anti-inflammatories

Doramapimod

Also known as BIRB-796, BIRB 796, BIRB796

CAS 285983-48-4Formula C31H37N5O3Molar mass 527.67 g/molEC 111-112-5
GHS signal word: Warning. Pictograms: Harmful or irritant 26 suppliers listed
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Doramapimod chemical structure, C31H37N5O3, CAS 285983-48-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
285983-48-4
Formula
C31H37N5O3
Molar mass
527.67 g/mol
EC number
111-112-5
HS code
293499
Category
Analgesics and anti-inflammatories

What is Doramapimod?

Plain description, key identifiers and synonyms

Doramapimod is a member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis. It has a role as an immunomodulator and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a member of naphthalenes, a member of pyrazoles, an aromatic ether, a member of morpholines and a member of ureas.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[3-tert-butyl-1-(4-methylphenyl)pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
CAS number
285983-48-4 CAS number cross-checked
EC number
111-112-5
Molecular formula
C31H37N5O3
UNII
HO1A8B3YVV
MDL number
MFCD09752957
InChIKey
MVCOAUNKQVWQHZ-UHFFFAOYSA-N
InChI
InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
SMILES (canonical and isomeric)
CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5

Synonyms

  • BIRB-796
  • BIRB 796
  • BIRB796
  • BIRB-796 BS
  • BIRB 796 BS
  • 3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea
  • Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-
  • 1-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-3-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea
  • Urea, N-(3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl)-N'-(4-(2-(4-morpholinyl)ethoxy)-1-naphthalenyl)-
  • 1-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl]urea
  • doramapimodum
  • 3-(3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl)-1-(4-(2-(morpholin-4-yl)ethoxy)naphthalen-1-yl)urea
  • 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3(4-(2-morpholin-4-yl-ethoxy)naph-thalen-1-yl)urea
  • BIRB 796 (Doramapimod)
  • Doramapimod (BIRB 796)
  • 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
  • 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea
  • Doramapimod (BIRB-796)
  • 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea
  • 1-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)naphthalen-1-yl)urea
  • BIRB 0796
  • BIRB-0796
  • 1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea
  • 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
  • 1-[3-(tert-Butyl)-1-(p-tolyl)-5-pyrazolyl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea
Show all 35 synonyms
  • 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
  • N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea
  • Doramapimod (USAN/INN)
  • Doramapimod (GMP)
  • Kinome_2137
  • 1kv2
  • BIRB 796,Doramapimod
  • diaryl urea compound 10
  • 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3(4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl)urea
  • BIRB 796BS

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
527.67 g/molcalc.
Exact mass
527.2896 Dacalc.
LogP (octanol/water)
5.99calc.
Topological polar surface area
80.65 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
7calc.
Heavy atoms
39calc.
Rings
5calc.
Aromatic rings
4calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Fails (2 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccc(OCCN2CCOCC2)c2ccccc12)Nc1ccnn1-c1ccccc1

O=C(Nc1ccc(OCCN2CCOCC2)c2ccccc12)Nc1ccnn1-c1ccccc1

5 rings, 34 atoms.

2 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Doramapimod suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 26 suppliers
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Where suppliers are based

26 suppliers in 6 countries

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Doramapimod price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antipsoriatic
  • antirheumatic drug
  • dermatologic drug
  • enzyme inhibitor
  • immunomodulator
  • pharmaceutical
  • protein kinase inhibitor

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Doramapimod is traded under.

HS 2934.99Indicative HS code

Nucleic acids and their salts, other heterocyclic compounds, not elsewhere classified in heading 2934

World exports in 2024
$26.7B
+15.0% vs 2023, imports $26.3B
2019 to 2024
Top exporters
  1. Ireland26.3%
  2. China15.7%
  3. Singapore10.3%
Top importers
  1. United States24.5%
  2. Germany23.1%
  3. Japan4.5%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Doramapimod is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Doramapimod, based on the data on this page

What is Doramapimod?

Doramapimod is a member of the class of pyrazoles that is an immunomodulator used for treatment of rheumatoid arthritis, Crohn's disease and psoriasis. It has a role as an immunomodulator and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor.

What is the CAS number of Doramapimod?

The CAS registry number of Doramapimod is 285983-48-4.

What is the molecular formula and weight of Doramapimod?

The molecular formula of Doramapimod is C31H37N5O3 and its molar mass is 527.67 g/mol.

What is Doramapimod used for?

Known uses and roles of Doramapimod include anti-inflammatories in pharmaceuticals, antipsoriatic, antirheumatic drug, dermatologic drug, enzyme inhibitor and 3 more.

Is Doramapimod hazardous?

Doramapimod carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Doramapimod?

Doramapimod is usually classified under HS code 293499 (Nucleic acids and their salts, whether or not chemically defined, other heterocyclic…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Doramapimod?

CompoundList lists 26 suppliers of Doramapimod in China, United States, Canada, Germany and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Doramapimod?

Suppliers quote Doramapimod on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Doramapimod

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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