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Central nervous system drugs

Droperidol

Also known as Droleptan, Dehydrobenzperidol, Inapsine

CAS 548-73-2Formula C22H22FN3O2Molar mass 379.44 g/molEC 208-957-8
GHS signal word: Warning. Pictograms: Harmful or irritant 89 suppliers listed Drug substance
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Droperidol chemical structure, C22H22FN3O2, CAS 548-73-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White to light tan, amorphous or microcrystalline powder
Melting point
145 to 146
Solubility
1 g soluble in 5.5 mL chloroform, 600 mL alcohol, 10,000 mL water, slightly soluble in e…
HS code
293339
Category
Central nervous system drugs
Illustrative photo, fine white powder in a clear glass bottle on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Droperidol?

Plain description, key identifiers and synonyms

Droperidol is an organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group. It is used in the management of chemotherapy-induced nausea and vomiting, and in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It has a role as a dopaminergic antagonist, an antiemetic, an anaesthesia adjuvant and a first generation antipsychotic. It is a member of benzimidazoles, an organofluorine compound and an aromatic ketone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
3-[1-[4-(4-fluorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
CAS number
548-73-2 CAS number cross-checked
EC number
208-957-8
Molecular formula
C22H22FN3O2
UNII
O9U0F09D5X
MDL number
MFCD00083290
InChIKey
RMEDXOLNCUSCGS-UHFFFAOYSA-N
InChI
InChI=1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)
SMILES (canonical and isomeric)
C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F

Synonyms

  • Droleptan
  • Dehydrobenzperidol
  • Inapsine
  • Dridol
  • Properidol
  • Sintodril
  • Sintosian
  • Halkan
  • Inapsin
  • Deidrobenzperidolo
  • Inopsin
  • McN-JR-4749
  • Droperidolo
  • Droperidolum
  • 1-(1-(3-(p-Fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
  • 1-(1-(4-(p-Fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
  • 2H-Benzimidazol-2-one, 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridinyl)-1,3-dihydro-
  • 2H-Benzimidazol-2-one, 1-[1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-
  • 1-[1-[3-(p-Fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone
  • 1-{1-[4-(4-Fluoro-phenyl)-4-oxo-butyl]-1,2,3,6-tetrahydro-pyridin-4-yl}-1,3-dihydro-benzoimidazol-2-one
  • 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
  • 2-Benzimidazolinone, 1-(1-(3-(p-fluorobenzoyl)propyl)-1,2,3,6-tetrahydro-4-pyridyl)-
  • 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridinyl}-2,3-dihydro-1H-benzo[d]imidazol-2-one
  • 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydropyridin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
  • 1-[1-[4-(p-Fluorophenyl)-4-oxobutyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinone
Show all 38 synonyms
  • 2-Benzimidazolinone, 1-[1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl]-
  • 1-(1-[3-(p-fluorobenzoyl)propyl]-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone
  • 1-(1-(4-(4-Fluoro-phenyl)-4-oxo-butyl)-1,2,3,6-tetrahydro-pyridin-4-yl)-1,3-dihydro-benzoimidazol-2-one
  • 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydro-4-pyridinyl)-2,3-dihydro-1H-benzo(d)imidazol-2-one
  • 1-(1-(4-(4-Fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridin-4-yl)-1,3-dihydro-2H-benzimidazol-2-one
  • 1-(1-(4-(4-fluorophenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridin-4-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one
  • 1-(4-fluorophenyl)-4-(4-(2-hydroxy-1H-1,3-benzodiazol-1-yl)-1,2,3,6-tetrahydropyridin-1-yl)butan-1-one
  • 1-(4-fluorophenyl)-4-[4-(2-hydroxy-1H-1,3-benzodiazol-1-yl)-1,2,3,6-tetrahydropyridin-1-yl]butan-1-one
  • DHBP
  • Vetkalm
  • Innovar
  • Thalamonal
  • Inappin

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White to light tan, amorphous or microcrystalline powderexp.
Odour
Odorlessexp.
Taste
Tasteless (no taste test is recommended)exp.
Melting point
145 to 146exp.
Solubility
1 g soluble in 5.5 mL chloroform, 600 mL alcohol, 10,000 mL water, slightly soluble in etherexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
379.44 g/molcalc.
Exact mass
379.1696 Dacalc.
LogP (octanol/water)
3.68calc.
Topological polar surface area
58.1 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
6calc.
Heavy atoms
28calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.27calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccccc1

O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccccc1

4 rings, 27 atoms, the 3-[1-(4-Oxo-4-phenylbutyl)-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one ring system.

11 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
Precautionary statements (5)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P301 + P317If swallowed: Get medical help.
  • P330Rinse mouth.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Droperidol suppliers

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All 89 suppliers
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Where suppliers are based

89 suppliers in 17 countries

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Droperidol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Use classes: Pharmaceuticals, Animal Drugs.

Industries and functions

Pharmacological actions

  • Adjuvants, Anesthesia
  • Antiemetics
  • Antipsychotic Agents
  • Dopamine D2 Receptor Antagonists

Roles

  • adjuvant
  • anaesthesia adjuvant
  • analgesic
  • antagonist
  • antiemetic
  • antipsychotic agent
  • central nervous system depressant
  • central nervous system drug
  • dopaminergic agent
  • dopaminergic antagonist
  • first generation antipsychotic
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • tranquilizing drug

Pharmacology

Droperidol is a Dopamine-2 Receptor Antagonist. The mechanism of action of droperidol is as a Dopamine D2 Antagonist.

How it is made

4-Chloro-4'-fluorobutyrophenone is prepared from gamma-butyrolactone and reacted with 1-(1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone in presence of a suitable condensing agent.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Droperidol is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Droperidol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Droperidol, based on the data on this page

What is Droperidol?

Droperidol is an organofluorine compound that is haloperidol in which the hydroxy group has been eliminated with the introduction of a double bond in the piperidine ring, and the 4-chlorophenyl group has been replaced by a benzimidazol-2-on-1-yl group.

What is the CAS number of Droperidol?

The CAS registry number of Droperidol is 548-73-2.

What is the molecular formula and weight of Droperidol?

The molecular formula of Droperidol is C22H22FN3O2 and its molar mass is 379.44 g/mol.

What is Droperidol used for?

Veterinary medication:. Use classes: Pharmaceuticals, Animal Drugs.

Is Droperidol hazardous?

Droperidol carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Droperidol?

Droperidol is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Droperidol?

CompoundList lists 89 suppliers of Droperidol in United States, China, Germany, United Kingdom and 13 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Droperidol in India?

2 suppliers in India list Droperidol on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Droperidol?

Suppliers quote Droperidol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Droperidol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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