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Murcko scaffold

3-[1-(4-Oxo-4-phenylbutyl)-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one scaffold

12 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
27
Chemicals
12
With full pages
2
Scaffold SMILES

O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-[1-(4-Oxo-4-phenylbutyl)-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one page
Murcko scaffold O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

Droperidol chemical structure, C22H22FN3O2, CAS 548-73-2
Droperidol
CAS 548-73-2C22H22FN3O2
Droperidol, fentanyl citrate chemical structure, C50H58FN5O10, CAS 8067-59-2
Droperidol, fentanyl citrate
CAS 8067-59-2C50H58FN5O10
Droperidol EP impurity B chemical structure, C22H22FN3O2, CAS 1026015-45-1
Droperidol EP impurity B
CAS 1026015-45-1C22H22FN3O2
Droperidol impurity D as hydrochloride chemical structure, C22H23ClFN3O3, CAS 2724689-73-8
Droperidol impurity D as hydrochloride
CAS 2724689-73-8C22H23ClFN3O3
Droperidol N-oxide chemical structure, C22H22FN3O3, CAS 466118-75-2
Droperidol N-oxide
CAS 466118-75-2C22H22FN3O3
3-[1-[4-(4-tert-Butylphenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one chemical structure, C26H31N3O2, CAS 2147-89-9
3-[1-[4-(4-tert-Butylphenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
CAS 2147-89-9C26H31N3O2
3-[1-[4-Oxo-4-(4-propan-2-ylphenyl)butyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one chemical structure, C25H29N3O2, CAS 2147-90-2
3-[1-[4-Oxo-4-(4-propan-2-ylphenyl)butyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
CAS 2147-90-2C25H29N3O2
3-[1-[4-(4-Ethylphenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one chemical structure, C24H27N3O2, CAS 2147-91-3
3-[1-[4-(4-Ethylphenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
CAS 2147-91-3C24H27N3O2
3-[1-[4-(4-Chlorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one chemical structure, C22H22ClN3O2, CAS 2147-93-5
3-[1-[4-(4-Chlorophenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
CAS 2147-93-5C22H22ClN3O2
3-[1-[4-(2,5-Dimethylphenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one chemical structure, C24H27N3O2, CAS 2147-94-6
3-[1-[4-(2,5-Dimethylphenyl)-4-oxobutyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
CAS 2147-94-6C24H27N3O2
3-[1-(4-Oxo-4-phenylbutyl)-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one chemical structure, C22H23N3O2, CAS 2318-32-3
3-[1-(4-Oxo-4-phenylbutyl)-3,6-dihydro-2H-pyridin-4-yl]-1H-benzimidazol-2-one
CAS 2318-32-3C22H23N3O2
1-(1-(4-(4-Hydroxyphenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one chemical structure, C22H23N3O3, CAS 466118-73-0
1-(1-(4-(4-Hydroxyphenyl)-4-oxobutyl)-1,2,3,6-tetrahydropyridin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one
CAS 466118-73-0C22H23N3O3