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Oncology and immunology drugs

Elacestrant

Also known as Orserdu, elacestrantum, (6R)-6-{2-[ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

CAS 722533-56-4Formula C30H38N2O2Molar mass 458.65 g/molEC 861-036-8
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Elacestrant chemical structure, C30H38N2O2, CAS 722533-56-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
722533-56-4
Formula
C30H38N2O2
Molar mass
458.65 g/mol
EC number
861-036-8
HS code
292229
Category
Oncology and immunology drugs

What is Elacestrant?

Plain description, key identifiers and synonyms

Elacestrant is a member of the class of tetralins that is 1,2,3,4-tetrahydronaphthalene which is substituted by hydroxy group at position 2 and by a 2-(ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl group at position 6R. It is a is an estrogen receptor degrader indicated for the treatment of postmenopausal women or adult men, with ER-positive, HER2-negative, ESR1-mutated advanced or metastatic breast cancer with disease progression following at least one line of endocrine therapy. It has a role as an antineoplastic agent, an anti-estrogen and an estrogen receptor antagonist. It is a monomethoxybenzene, an organic hydroxy compound, a member of tetralins, a substituted aniline, a secondary amino compound and a tertiary amino compound.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6R)-6-[2-[ethyl-[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
CAS number
722533-56-4
EC number
861-036-8
Molecular formula
C30H38N2O2
UNII
FM6A2627A8
MDL number
MFCD30532693
InChIKey
SIFNOOUKXBRGGB-AREMUKBSSA-N
InChI
InChI=1S/C30H38N2O2/c1-4-31-17-16-22-6-8-23(9-7-22)21-32(5-2)30-20-28(34-3)14-15-29(30)26-11-10-25-19-27(33)13-12-24(25)18-26/h6-9,12-15,19-20,26,31,33H,4-5,10-11,16-18,21H2,1-3H3/t26-/m1/s1
Canonical SMILES
CCNCCc1ccc(CN(CC)c2cc(OC)ccc2C2CCc3cc(O)ccc3C2)cc1
Isomeric SMILES
CCNCCC1=CC=C(C=C1)CN(CC)C2=C(C=CC(=C2)OC)[C@@H]3CCC4=C(C3)C=CC(=C4)O

Synonyms

  • Orserdu
  • elacestrantum
  • (6R)-6-{2-[ethyl({4-[2-(ethylamino)ethyl]phenyl}methyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
  • (2R)-2-(2-(Ethyl-((4-(2-(ethylamino)ethyl)phenyl)methyl)amino)-4-methoxy-phenyl)tetralin-6-ol
  • 2-Naphthalenol, 6-(2-(ethyl((4-(2-(ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydro-, (6R)-
  • (2R)-2-[2-[ethyl-[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxy-phenyl]tetralin-6-ol
  • (6R)-6-(2-(Ethyl((4-(2-(ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol
  • 2-Naphthalenol, 6-[2-[ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydro-, (6R)-
  • SERD/SERM RAD1901
  • (6R)-6-[2-[ethyl-[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
  • (R)-6-(2-(Ethyl(4-(2-(ethylamino)ethyl)benzyl)amino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol
  • (6R)-6-[2-[Ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydro-2-naphthalenol
  • (6R)-6-(2-(Ethyl((4-(2- (ethylamino)ethyl)phenyl)methyl)amino)-4-methoxyphenyl)- 5,6,7,8-tetrahydronaphthalen-2-ol
  • (R)-6-[2-[Ethyl[4-[2-(ethylamino)ethyl]benzyl]amino]-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
  • Elacestrant (USAN/INN)
  • RAD 1901
  • US10208011, Compound RAD-
  • WHO 10247
  • (6R)-6-[2-(ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl]-5,6,7,8-tetrahydronaphthalen-2-ol
  • (6R)-6-[2-[ethyl[[4-[2-(ethylamino)ethyl]phenyl]methyl]amino]-4-methoxyphenyl]-5, 6,7,8-tetrahydro-2-Naphthalenol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
458.65 g/molcalc.
Exact mass
458.2933 Dacalc.
LogP (octanol/water)
5.85calc.
Topological polar surface area
44.73 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
10calc.
Heavy atoms
34calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.4calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CNc2ccccc2C2CCc3ccccc3C2)cc1

c1ccc(CNc2ccccc2C2CCc3ccccc3C2)cc1

4 rings, 24 atoms.

14 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Elacestrant suppliers

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All 7 suppliers
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Where suppliers are based

7 suppliers in 2 countries

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Elacestrant price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Industries and functions

Pharmacological actions

  • Antineoplastic Agents

Roles

  • antagonist
  • anti-estrogen
  • antineoplastic agent
  • estrogen receptor antagonist
  • pharmaceutical

Pharmacology

Elacestrant is an Estrogen Receptor Antagonist. The mechanism of action of elacestrant is as an Estrogen Receptor Antagonist, and P-Glycoprotein Inhibitor, and Breast Cancer Resistance Protein Inhibitor.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Elacestrant is traded under.

HS 2922.29Indicative HS code

Amino-naphthols and other amino-phenols, other than those containing more than one kind…

World exports in 2024
$467M
−15.3% vs 2023, imports $454M
2019 to 2024
Top exporters
  1. China63.1%
  2. India * partner reported15.5%
  3. Japan4.0%
Top importers
  1. India * partner reported25.8%
  2. United States14.4%
  3. South Korea7.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Elacestrant is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Elacestrant, based on the data on this page

What is Elacestrant?

Elacestrant is a member of the class of tetralins that is 1,2,3,4-tetrahydronaphthalene which is substituted by hydroxy group at position 2 and by a 2-(ethyl{4-[2-(ethylamino)ethyl]benzyl}amino)-4-methoxyphenyl group at position 6R.

What is the CAS number of Elacestrant?

The CAS registry number of Elacestrant is 722533-56-4.

What is the molecular formula and weight of Elacestrant?

The molecular formula of Elacestrant is C30H38N2O2 and its molar mass is 458.65 g/mol.

What is Elacestrant used for?

Known uses and roles of Elacestrant include anticancer drugs in pharmaceuticals, antagonist, anti-estrogen, antineoplastic agent, estrogen receptor antagonist and 2 more.

Is Elacestrant hazardous?

No GHS hazard classification for Elacestrant is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Elacestrant?

Elacestrant is usually classified under HS code 292229 (Amino-naphthols and other amino-phenols, other than those containing more than one kind…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Elacestrant?

CompoundList lists 7 suppliers of Elacestrant in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Elacestrant?

Suppliers quote Elacestrant on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Elacestrant

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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