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Vitamins and nutraceutical actives

Ergosterol

Also known as Provitamin D2, Ergosterin, (22E)-ergosta-5,7,22-trien-3beta-ol

CAS 57-87-4Formula C28H44OMolar mass 396.66 g/molEC 200-352-7
GHS signal word: Danger. Pictograms: Acute toxicity (severe) 81 suppliers listed
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Ergosterol chemical structure, C28H44O, CAS 57-87-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Small hydrated plates from alcohol, in hydrated needles from ether. The best crystalized…
Melting point
170 °C
Boiling point
250 °C
Density
1.04
Solubility
Slightly soluble in ethanol, ethyl ether, petroleum ether, soluble in benzene, chloroform
HS code
290613
Category
Vitamins and nutraceutical actives
Illustrative photo, 25 kg white woven sacks of powder on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Ergosterol?

Plain description, key identifiers and synonyms

Ergosterol is a phytosterol consisting of ergostane having double bonds at the 5,6-, 7,8- and 22,23-positions as well as a 3beta-hydroxy group. It has a role as a Saccharomyces cerevisiae metabolite and a fungal metabolite. It is a 3beta-hydroxy-Delta(5)-steroid, a member of phytosterols, a 3beta-sterol and an ergostanoid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(3S,9S,10R,13R,14R,17R)-17-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
CAS number
57-87-4 CAS number cross-checked
EC number
200-352-7
Molecular formula
C28H44O
UNII
Z30RAY509F
MDL number
MFCD00003623
INCI name
ERGOSTEROL
InChIKey
DNVPQKQSNYMLRS-APGDWVJJSA-N
InChI
InChI=1S/C28H44O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,18-20,22,24-26,29H,11-17H2,1-6H3/b8-7+/t19-,20+,22-,24+,25-,26-,27-,28+/m0/s1
Canonical SMILES
CC(C)C(C)C=CC(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC21C
Isomeric SMILES
C[C@H](/C=C/[C@H](C)C(C)C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3C2=CC=C4[C@@]3(CC[C@@H](C4)O)C)C

Synonyms

  • Provitamin D2
  • Ergosterin
  • (22E)-ergosta-5,7,22-trien-3beta-ol
  • Ergosta-5,7,22E-trien-3beta-ol
  • Provitamin D 2
  • Ergosta-5,7,22-trien-3beta-ol
  • (22E,24S)-24-methylcholesta-5,7,22-trien-3beta-ol
  • (3S,9S,10R,13R,14R,17R)-17-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
  • Pro Vitamin D2
  • Pro-Vitamin D2
  • (3S,9S,10R,13R,14R,17R)-17-((E,2R,5R)-5,6-dimethylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta(a)phenanthren-3-ol
  • D2, Pro-Vitamin
  • Ergocalciferol EP Impurity B
  • Ergosta-5,7,22-trien-3-ol, (3b,22E)-
  • Ergosterol (Provitamin D2)
  • 24-Methylcholesta-5,7,22-trien-3beta-ol
  • (3S,9S,10R,13R,14R,17R)-17-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
  • (22e,24r)-ergosta-5,7,22-trien-3beta-ol
  • 3beta-Hydroxy-5,7,22-ergostatriene
  • (3beta,22E)-Ergosta-5,7,22-trien-3-ol
  • 14-((2E)(1R,4R)-1,4,5-trimethylhex-2-enyl)(1S,5S,2R,11R,14R,15R)-2,15-dimethyl tetracyclo[8.7.0.0<2,7>.0<11,15>]heptadeca-7,9-dien-5-ol
  • (3S,9S,10R,13R,14R,17R)-10,13-dimethyl-17-[(E,1R,4R)-1,4,5-trimethylhex-2-enyl]-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
  • Ergosta-5,7,22-trien-3-ol, (3beta,22E)-
  • ergosta-5,7,22-trien-3-ol
  • Ergosterol CRS
Show all 34 synonyms
  • Provitamine D2
  • (3S,9S,10R,13R,14R,17R)-17-[(2R,5R,E)-5,6-Dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
  • ERG
  • Ergosterin(Standard)
  • 24alpha-Methyl-22E-dehydrocholesterol
  • Ergosterol (Standard)
  • Lumisterol Impurity 2
  • Ergosterol, >=75%
  • 24R-Methylcholesta-5,7,2E-trien-3beta-ol

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Small hydrated plates from alcohol, in hydrated needles from ether. The best crystalized form contains 1 1/2 mol H2Oexp.
Melting point
170 °Cexp.
Boiling point
250 °Cexp.
Density
1.04exp.
Solubility
Slightly soluble in ethanol, ethyl ether, petroleum ether, soluble in benzene, chloroformexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
396.66 g/molcalc.
Exact mass
396.3392 Dacalc.
LogP (octanol/water)
7.33calc.
Topological polar surface area
20.23 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
4calc.
Heavy atoms
29calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.79calc.
Formal charge
0calc.
Stereocentres
8calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1=C2CCCCC2C2CCC3CCCC3C2=C1

C1=C2CCCCC2C2CCC3CCCC3C2=C1

4 rings, 17 atoms.

78 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)

Hazard statements

  • H300Fatal if swallowed.
  • H413May cause long lasting harmful effects to aquatic life.
Precautionary statements (8)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P273Avoid release to the environment.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ergosterol suppliers

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All 81 suppliers
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Where suppliers are based

81 suppliers in 13 countries

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Ergosterol price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Chemical intermediate for vitamin d2.

Antirachitic vitamin, when irradiated with UV light, it has vitamin D activity, source of estradiol.

Used in commercial production of cortisone.

Therapeutic category: Vitamin (antirachitic).

Ergosterol is an evolutionary precursor of cholesterol and is the major sterol present in lower eukaryotes.

Use classes: Cosmetics.

Cosmetic ingredient, INCI name ERGOSTEROL(skin conditioning)

Pharmacological actions

  • Provitamins

Roles

  • Saccharomyces cerevisiae metabolite
  • eukaryotic metabolite
  • fungal metabolite
  • metabolite

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

How it is made

Extraction of total fat from yeast, saponification, reextraction of the unsaponifiable portion with ether, followed by drying & recrystallization

Usually obtained from yeast which synthesizes it from simple sugars such as glucose. Damp yeast yields about 2.5% ergosterol, the variety of yeast being very important.

Isoln procedure: Green et al, US pat 3,006932 (1961 to Vitamins Ltd.)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ergosterol is traded under.

HS 2906.13Indicative HS code

Sterols and inositols

World exports in 2024
$316M
−12.1% vs 2023, imports $291M
2019 to 2024
Top exporters
  1. China42.0%
  2. United States16.4%
  3. Netherlands9.6%
Top importers
  1. Ecuador * partner reported13.0%
  2. China13.0%
  3. United States9.4%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ergosterol is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ergosterol, based on the data on this page

What is Ergosterol?

Ergosterol is a phytosterol consisting of ergostane having double bonds at the 5,6-, 7,8- and 22,23-positions as well as a 3beta-hydroxy group. It has a role as a Saccharomyces cerevisiae metabolite and a fungal metabolite.

What is the CAS number of Ergosterol?

The CAS registry number of Ergosterol is 57-87-4.

What is the molecular formula and weight of Ergosterol?

The molecular formula of Ergosterol is C28H44O and its molar mass is 396.66 g/mol.

What is Ergosterol used for?

Chemical intermediate for vitamin d2. Antirachitic vitamin, when irradiated with UV light, it has vitamin D activity, source of estradiol. Used in commercial production of cortisone. Therapeutic category: Vitamin (antirachitic).

Is Ergosterol hazardous?

Ergosterol carries the GHS signal word "Danger". Main hazards: fatal if swallowed, may cause long lasting harmful effects to aquatic life. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ergosterol?

Ergosterol is usually classified under HS code 290613 (Sterols and inositols). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ergosterol?

CompoundList lists 81 suppliers of Ergosterol in China, United States, Germany, United Kingdom and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Ergosterol?

Suppliers quote Ergosterol on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Ergosterol

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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