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Central nervous system drugs

Estazolam

Also known as Eurodin, ProSom, Esilgan

CAS 29975-16-4Formula C16H11ClN4Molar mass 294.75 g/molEC 249-982-4
GHS signal word: Warning. Pictograms: Harmful or irritant Prohibited, not for trade Drug substance
Why it is not for trade
Estazolam chemical structure, C16H11ClN4, CAS 29975-16-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
29975-16-4
Formula
C16H11ClN4
Molar mass
294.75 g/mol
EC number
249-982-4
HS code
293391
Category
Central nervous system drugs

What is Estazolam?

Plain description, key identifiers and synonyms

Estazolam is a triazolo[4,3-a][1,4]benzodiazepine having a phenyl group at position 6 and a chloro substituent at position 8. A short-acting benzodiazepine with general properties similar to diazepam, it is given by mouth as a hypnotic in the short-term management of insomnia. It has a role as an anxiolytic drug, an anticonvulsant and a GABA modulator. It is a triazolobenzodiazepine and a member of triazoles.

Estazolam is a benzodiazepine derivative drug.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
8-chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS number
29975-16-4 CAS number cross-checkedOther or deprecated CAS: 53180-72-6
EC number
249-982-4
Molecular formula
C16H11ClN4
UNII
36S3EQV54C
InChIKey
CDCHDCWJMGXXRH-UHFFFAOYSA-N
InChI
InChI=1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2
SMILES (canonical and isomeric)
C1C2=NN=CN2C3=C(C=C(C=C3)Cl)C(=N1)C4=CC=CC=C4

Synonyms

  • Eurodin
  • ProSom
  • Esilgan
  • D 40TA
  • Estazolamum
  • 8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
  • Estazolam civ
  • 8-Chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine
  • 4H-(1,2,4)Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl-
  • 8-Chloro-6-phenyl-4H-(1,2,4)triazolo-(4,3-a)(1,4)benzodiazepine
  • 8-Chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
  • 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine, 8-chloro-6-phenyl-
  • 8-Chloro-6-phenyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepine
  • 12-chloro-9-phenyl-2,4,5,8-tetraazatricyclo(8.4.0.0^(2,6))tetradeca-1(10),3,5,8,11,13-hexaene
  • 12-chloro-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene
  • 12-chloro-9-phenyl-2,4,5,8-tetraazatricyclo(8.4.0.02,6)tetradeca-1(10),3,5,8,11,13-hexaene
  • Julodin
  • Nuctalon
  • Somnatrol
  • Nemurel
  • Cannoc
  • 4H-s-Triazolo(4,3-a)(1,4)benzodiazepine, 8-chloro-6-phenyl-
  • 8-Chloro-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine
  • Abbott 47631
  • Prosom (TN)
Show all 28 synonyms
  • DEA No. 2756
  • 8-Chloro-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine (IUPAC)
  • 8-Chloro-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
294.75 g/molcalc.
Exact mass
294.0672 Dacalc.
LogP (octanol/water)
3.27calc.
Topological polar surface area
43.07 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
21calc.
Rings
4calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.06calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(C2=NCc3nncn3-c3ccccc32)cc1

c1ccc(C2=NCc3nncn3-c3ccccc32)cc1

4 rings, 20 atoms.

89 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Estazolam suppliers

Trading restrictions apply to this substance

Psychotropic substance

Estazolam is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.91 (benzodiazepines and related substances)

Our policy on controlled substances

Estazolam price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Anti-Anxiety Agents
  • Anticonvulsants
  • GABA Modulators

Roles

  • GABA agent
  • GABA modulator
  • anticonvulsant
  • anxiolytic drug
  • biophysical role
  • central nervous system depressant
  • central nervous system drug
  • membrane transport modulator
  • neurotransmitter agent
  • pharmaceutical
  • psychotropic drug
  • tranquilizing drug

Pharmacology

Estazolam is a Benzodiazepine.

Regulatory status

Inventories, regulations and trade controls that list this substance

Psychotropic substance

Estazolam is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.91 (benzodiazepines and related substances)

Our policy on controlled substances

Controls

  • US DEA controlled substance or listed chemical
  • Controlled psychotropic substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Estazolam is traded under.

HS 2933.91Exact HS code

Alprazolam (INN), camazepam (INN), chlordiazepoxide (INN), clonazepam (INN)…

World exports in 2024
$118M
−26.3% vs 2023, imports $94.2M
2019 to 2024
Top exporters
  1. Italy37.7%
  2. United States22.7%
  3. India * partner reported9.8%
Top importers
  1. Germany13.8%
  2. Spain10.4%
  3. United States10.2%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Estazolam is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Estazolam, based on the data on this page

What is Estazolam?

Estazolam is a triazolo[4,3-a][1,4]benzodiazepine having a phenyl group at position 6 and a chloro substituent at position 8. A short-acting benzodiazepine with general properties similar to diazepam, it is given by mouth as a hypnotic in the short-term management of insomnia.

What is the CAS number of Estazolam?

The CAS registry number of Estazolam is 29975-16-4. Other or deprecated CAS numbers: 53180-72-6.

What is the molecular formula and weight of Estazolam?

The molecular formula of Estazolam is C16H11ClN4 and its molar mass is 294.75 g/mol.

What is Estazolam used for?

Use classes: Pharmaceuticals.

Is Estazolam hazardous?

Estazolam carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Estazolam?

Estazolam is usually classified under HS code 293391 (Alprazolam (INN), camazepam (INN), chlordiazepoxide (INN), clonazepam (INN)…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Estazolam on CompoundList?

No. Estazolam is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Estazolam

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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