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Analgesics and anti-inflammatories

Fentanyl citrate

Also known as Leptanal, Oralet, Phentanyl citrate

CAS 990-73-8Formula C28H36N2O8Molar mass 528.60 g/molEC 213-588-0
GHS signal word: Danger. Pictograms: Acute toxicity (severe), Harmful or irritant, Serious health hazard Prohibited, not for trade Drug substance
Why it is not for trade
Fentanyl citrate chemical structure, C28H36N2O8, CAS 990-73-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
990-73-8
Formula
C28H36N2O8
Molar mass
528.60 g/mol
EC number
213-588-0
HS code
293339
Category
Analgesics and anti-inflammatories

What is Fentanyl citrate?

Plain description, key identifiers and synonyms

Fentanyl citrate is the citric acid salt of fentanyl, comprising equimolar amounts of citric acid and fentanyl. A -opioid receptor agonist, it is a potent opioid analgesic used in the management of labour pain, postoperative pain, and chronic intractable cancer pain. It is also widely used as the analgesic component of balanced anaesthesia. It has a role as an opioid analgesic and a mu-opioid receptor agonist. It contains a fentanyl.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-hydroxypropane-1,2,3-tricarboxylic acid, N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
CAS number
990-73-8 CAS number cross-checked
EC number
213-588-0
Molecular formula
C28H36N2O8
UNII
MUN5LYG46H
InChIKey
IVLVTNPOHDFFCJ-UHFFFAOYSA-N
InChI
InChI=1S/C22H28N2O.C6H8O7/c1-2-22(25)24(20-11-7-4-8-12-20)21-14-17-23(18-15-21)16-13-19-9-5-3-6-10-19;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-12,21H,2,13-18H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
SMILES (canonical and isomeric)
CCC(=O)N(C1CCN(CC1)CCC2=CC=CC=C2)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

Synonyms

  • Leptanal
  • Oralet
  • Phentanyl citrate
  • Actiq
  • Abstral
  • Lazanda
  • Onsolis
  • Instanyl
  • Fentanyl buccal
  • McN-JR-4263-49
  • Fentanyl citrate cii
  • Sublimaze preservative free
  • N-(1-Phenethyl-4-piperidyl)propionanilide citrate
  • Fentanyl citrate preservative free
  • Kw-2246
  • N-(1-Phenethyl-4-piperidyl)propionanilide dihydrogen citrate
  • N-(1-Phenethyl-4-piperidinyl)propionanilide dihydrogen citrate
  • Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
  • Fentyl
  • Fentanyl Nasal Spray
  • Transmucosal Fentanyl Citrate
  • N-(1-Phenethylpiperidin-4-yl)-N-phenylpropanamide monocitrate
  • Fentanyl dihydrogen citrate
  • Fentanyl citrate salt
  • Fentanyl.citrate
Show all 37 synonyms
  • N-(1-Phenethyl-4-piperidyl)propionanilide citrate (1:1)
  • Fentaz
  • N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide citrate
  • Fentanyl Citrate (1mg/ml in Methanol)
  • McN-JR 4263
  • fentanyl monocitrate
  • Abstral (TN)
  • Fentora (TN)
  • Lazanda (TN)
  • Oralet (TN)
  • Propionanilide, N-(1-phenethyl-4-piperidyl)-, citrate (1:1)
  • r-4263 Citrate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
528.60 g/molcalc.
Exact mass
528.2472 Dacalc.
LogP (octanol/water)
2.89calc.
Topological polar surface area
155.7 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
11calc.
Heavy atoms
38calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
0calc.
Components
2calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CCN2CCC(Nc3ccccc3)CC2)cc1

c1ccc(CCN2CCC(Nc3ccccc3)CC2)cc1

3 rings, 21 atoms, the N-Phenyl-1-(2-phenylethyl)-4-piperidinamine ring system.

368 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H300Fatal if swallowed.
  • H310Fatal in contact with skin.
  • H317May cause an allergic skin reaction.
  • H330Fatal if inhaled.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary statements (25)
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P316Get emergency medical help immediately.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Fentanyl citrate suppliers

Trading restrictions apply to this substance

Narcotic drug

Fentanyl citrate is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961

Our policy on controlled substances

Fentanyl citrate price

Indicative price range per kg from live supplier offers

Prices are not shown for prohibited substances.

Uses and applications

What the substance is used for, by industry and function

Use classes: Animal Drugs.

Roles

  • agonist
  • analgesic
  • anti-inflammatory agent
  • antineoplastic agent
  • mu-opioid agent
  • mu-opioid receptor agonist
  • neurotransmitter agent
  • opioid agent
  • opioid analgesic
  • opioid receptor agonist
  • pharmaceutical
  • vulnerary

Pharmacology

Fentanyl Citrate is the citrate salt of fentanyl, a synthetic opioid related to the phenylpiperidines with analgesic and anesthetic properties. Fentanyl exerts its analgesic effect by selectively binding to the mu-opioid receptor in the central nervous system (CNS), thereby mimicking the effects of endogenous opiates. Additional pharmacological effects of fentanyl include anxiolysis, euphoria, feelings of relaxation, respiratory depression, constipation, miosis, and cough suppression.

Regulatory status

Inventories, regulations and trade controls that list this substance

Narcotic drug

Fentanyl citrate is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.

Listing and enquiries are not allowed for this substance.

Reference: UN Single Convention on Narcotic Drugs 1961

Our policy on controlled substances

Health and food

  • Active ingredient in FDA approved drug labels

Controls

  • Controlled narcotic drug

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fentanyl citrate is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Fentanyl citrate is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fentanyl citrate, based on the data on this page

What is Fentanyl citrate?

Fentanyl citrate is the citric acid salt of fentanyl, comprising equimolar amounts of citric acid and fentanyl. A -opioid receptor agonist, it is a potent opioid analgesic used in the management of labour pain, postoperative pain, and chronic intractable cancer pain.

What is the CAS number of Fentanyl citrate?

The CAS registry number of Fentanyl citrate is 990-73-8.

What is the molecular formula and weight of Fentanyl citrate?

The molecular formula of Fentanyl citrate is C28H36N2O8 and its molar mass is 528.60 g/mol.

What is Fentanyl citrate used for?

Use classes: Animal Drugs.

Is Fentanyl citrate hazardous?

Fentanyl citrate carries the GHS signal word "Danger". Main hazards: fatal if swallowed, fatal in contact with skin, may cause an allergic skin reaction. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Fentanyl citrate?

Fentanyl citrate is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Can I buy Fentanyl citrate on CompoundList?

No. Fentanyl citrate is on our prohibited list, so listings, quotes and messages for it are disabled. This page is kept for information only.

Guides for buyers

Practical guides that help when you source, ship or handle Fentanyl citrate

Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page

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