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Cardiovascular and metabolic drugs

Flecainide

Also known as Flecaine, N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide, Flecainida

CAS 54143-55-4Formula C17H20F6N2O3Molar mass 414.35 g/molEC 685-650-9
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 82 suppliers listed Drug substance
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Flecainide chemical structure, C17H20F6N2O3, CAS 54143-55-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
54143-55-4
Formula
C17H20F6N2O3
Molar mass
414.35 g/mol
EC number
685-650-9
HS code
293339
Category
Cardiovascular and metabolic drugs

What is Flecainide?

Plain description, key identifiers and synonyms

Flecainide is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart). It has a role as an anti-arrhythmia drug. It is a member of piperidines, a monocarboxylic acid amide, an aromatic ether and an organofluorine compound. It is a conjugate base of a flecainide(1+).

Flecainide is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
CAS number
54143-55-4 CAS number cross-checkedOther or deprecated CAS: 54143-56-5
EC numbers
685-650-9, 923-247-4
Molecular formula
C17H20F6N2O3
UNII
K94FTS1806
MDL number
MFCD00864713
InChIKey
DJBNUMBKLMJRSA-UHFFFAOYSA-N
InChI
InChI=1S/C17H20F6N2O3/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26)
SMILES (canonical and isomeric)
C1CCNC(C1)CNC(=O)C2=C(C=CC(=C2)OCC(F)(F)F)OCC(F)(F)F

Synonyms

  • Flecaine
  • N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • Flecainida
  • Flecainidum
  • (+-)-Flecainide
  • N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-
  • Thn-102 component flecainide
  • Flecainid Isis
  • Flecainide (INN)
  • N-(2-Piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • N-[(piperidin-2-yl)methyl]-2,5-bis(2,2,2-trifluoroethoxy)benzamide
  • (+/-)-flecainide
  • flecanide
  • rac Flecainide
  • rac-Flecainide
  • Flecaintde base
  • Flecainide (Standard)
  • Bio1_000375
  • Bio1_000864
  • Bio1_001353
  • Bio2_000037
  • Bio2_000517
  • Thn102 component flecainide
  • 2,5-bis(2,2,2-trifluoroethoxy)
Show all 27 synonyms
  • N-(piperidin-2-ylmethyl)-2,5-bis[(2,2,2-trifluoroethyl)oxy]benzamide
  • Flecainide component of thn-102

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
414.35 g/molcalc.
Exact mass
414.1378 Dacalc.
LogP (octanol/water)
3.44calc.
Topological polar surface area
59.59 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
7calc.
Heavy atoms
28calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.59calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(NCC1CCCCN1)c1ccccc1

O=C(NCC1CCCCN1)c1ccccc1

2 rings, 16 atoms, the N-[(Piperidin-2-yl)methyl]benzamide ring system.

24 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H336May cause drowsiness or dizziness.
  • H361Suspected of damaging fertility or the unborn child.
  • H361dSuspected of damaging the unborn child.
Precautionary statements (14)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P330Rinse mouth.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Flecainide suppliers

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All 82 suppliers
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Where suppliers are based

82 suppliers in 15 countries

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Flecainide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Arrhythmia Agents
  • Voltage-Gated Sodium Channel Blockers

Roles

  • anti-arrhythmia drug
  • cardiovascular drug
  • pharmaceutical

Pharmacology

Flecainide is an Antiarrhythmic.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Flecainide is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Flecainide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Flecainide, based on the data on this page

What is Flecainide?

Flecainide is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine.

What is the CAS number of Flecainide?

The CAS registry number of Flecainide is 54143-55-4. Other or deprecated CAS numbers: 54143-56-5.

What is the molecular formula and weight of Flecainide?

The molecular formula of Flecainide is C17H20F6N2O3 and its molar mass is 414.35 g/mol.

What is Flecainide used for?

Use classes: Pharmaceuticals.

Is Flecainide hazardous?

Flecainide carries the GHS signal word "Warning". Main hazards: harmful if swallowed, may cause drowsiness or dizziness, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Flecainide?

Flecainide is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Flecainide?

CompoundList lists 82 suppliers of Flecainide in United States, China, United Kingdom, Germany and 11 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Flecainide in India?

4 suppliers in India list Flecainide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Flecainide?

Suppliers quote Flecainide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Flecainide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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