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Antibiotics and anti-infectives

Fluconazole

Also known as Diflucan, Triflucan, Biozolene

CAS 86386-73-4Formula C13H12F2N6OMolar mass 306.28 g/molEC 627-806-0
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 322 suppliers listed Drug substance
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Fluconazole chemical structure, C13H12F2N6O, CAS 86386-73-4
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White crystalline powder
Melting point
138 to 140
Solubility
Poorly soluble in water but can be dissolved in organic solvents such as chloroform, pro…
HS code
293399
Category
Antibiotics and anti-infectives
Illustrative photo, off-white crystalline powder in an HDPE jar on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Fluconazole?

Plain description, key identifiers and synonyms

Fluconazole is a member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis. It has a role as a xenobiotic, a P450 inhibitor and an environmental contaminant. It is a tertiary alcohol, a difluorobenzene, a conazole antifungal drug and a triazole antifungal drug. It is functionally related to a 1,3-difluorobenzene. It derives from a hydride of a 1H-1,2,4-triazole.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
CAS number
86386-73-4 CAS number cross-checkedOther or deprecated CAS: 123631-92-5
EC numbers
627-806-0, 691-089-0
Molecular formula
C13H12F2N6O
UNII
8VZV102JFY
MDL number
MFCD00274549
InChIKey
RFHAOTPXVQNOHP-UHFFFAOYSA-N
InChI
InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2
SMILES (canonical and isomeric)
C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O

Synonyms

  • Diflucan
  • Triflucan
  • Biozolene
  • Elazor
  • Fluconazol
  • Zoltec
  • Flucostat
  • difluconazole
  • Fluconazolum
  • Flucazol
  • Flunizol
  • Pritenzol
  • 2-(2,4-Difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-ol
  • 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
  • 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
  • UK 49858
  • Alkanazole
  • Fluconazoli
  • Diflucan in sodium chloride 0.9%
  • 1H-1,2,4-Triazole-1-ethanol, alpha-(2,4-difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-
  • Fluconazole in sodium chloride 0.9%
  • Diflucan in dextrose 5% in plastic container
  • UK-49,858
  • 2,4-Difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol
  • Fluconazole in dextrose 5% in plastic container
Show all 36 synonyms
  • alpha-(2,4-Difluorophenyl)-alpha-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol
  • Fluconazole in sodium chloride 0.9% in plastic container
  • Diflucan in sodium chloride 0.9% in plastic container
  • Apo Fluconazole
  • Fluconazol Isis
  • Fluconazol ratiopharm
  • fluconazolo
  • Biozole
  • Canesten oral
  • Diflucan One
  • Expel-F

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White crystalline powderexp.
Melting point
138 to 140exp.
Solubility
Poorly soluble in water but can be dissolved in organic solvents such as chloroform, propylene glycol, and polyethoxylated castor oil (preparation for IV use but dangerous for dogs)exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
306.28 g/molcalc.
Exact mass
306.1041 Dacalc.
LogP (octanol/water)
0.74calc.
Topological polar surface area
81.65 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
5calc.
Heavy atoms
22calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0.23calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(C(Cn2cncn2)Cn2cncn2)cc1

c1ccc(C(Cn2cncn2)Cn2cncn2)cc1

3 rings, 19 atoms.

18 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H360May damage fertility or the unborn child.
  • H362May cause harm to breast-fed children.
  • H371May cause damage to organs.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (25)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P263Avoid contact during pregnancy and while nursing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P308 + P316If exposed or concerned: Get emergency medical help immediately.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Fluconazole suppliers

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All 322 suppliers
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Where suppliers are based

322 suppliers in 44 countries

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Fluconazole price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Mesh Heading: Antifungal agents.

Medication: Antifungal.

Veterinary medication:.

Use classes: Fungicides.

Industries and functions

Pharmacological actions

  • 14-alpha Demethylase Inhibitors
  • Antifungal Agents
  • Cytochrome P-450 CYP2C19 Inhibitors
  • Cytochrome P-450 CYP2C9 Inhibitors

Roles

  • P450 inhibitor
  • anti-HIV agent
  • anti-inflammatory agent
  • antibacterial agent
  • antifungal agent
  • antihypertensive agent
  • antiinfective agent
  • antileishmanial agent
  • antimicrobial agent
  • antimicrobial drug
  • antineoplastic agent
  • antiparasitic agent
  • antiprotozoal drug
  • antiviral agent
  • cardiovascular drug
  • environmental contaminant
  • enzyme inhibitor
  • pharmaceutical
  • xenobiotic

Pharmacology

Fluconazole is an Azole Antifungal. The mechanism of action of fluconazole is as a Cytochrome P450 2C19 Inhibitor, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inhibitor.

How it is made

K. Richardson, United Kingdom 2099818, US patent 4404216 (1982, 1983 both to Pfizer).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fluconazole is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Fluconazole is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fluconazole, based on the data on this page

What is Fluconazole?

Fluconazole is a member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group.

What is the CAS number of Fluconazole?

The CAS registry number of Fluconazole is 86386-73-4. Other or deprecated CAS numbers: 123631-92-5.

What is the molecular formula and weight of Fluconazole?

The molecular formula of Fluconazole is C13H12F2N6O and its molar mass is 306.28 g/mol.

What is Fluconazole used for?

Mesh Heading: Antifungal agents. Medication: Antifungal. Veterinary medication:. Use classes: Fungicides.

Is Fluconazole hazardous?

Fluconazole carries the GHS signal word "Danger". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Fluconazole?

Fluconazole is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Fluconazole?

CompoundList lists 322 suppliers of Fluconazole in India, United States, China, Bangladesh and 40 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Fluconazole in India?

125 suppliers in India list Fluconazole on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Fluconazole?

Suppliers quote Fluconazole on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Fluconazole

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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