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Screening compounds

Flumethiazide

Also known as Ademol, Trifluoromethylthiazide, Flumethiazid

CAS 148-56-1Formula C8H6F3N3O4S2Molar mass 329.28 g/molEC 205-717-4
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Flumethiazide chemical structure, C8H6F3N3O4S2, CAS 148-56-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
148-56-1
Formula
C8H6F3N3O4S2
Appearance
Crystals
Solubility
SPARINGLY SOL IN WATER, 50 MG/ML IN BOILING WATER WITH DECOMP, PRACTICALLY INSOL IN ETHY…
HS code
293590
Category
Screening compounds
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is Flumethiazide?

Plain description, key identifiers and synonyms

Flumethiazide is a benzothiadiazine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,1-dioxo-6-(trifluoromethyl)-4H-1λ6,2,4-benzothiadiazine-7-sulfonamide
CAS number
148-56-1 CAS number cross-checked
EC number
205-717-4
Molecular formula
C8H6F3N3O4S2
UNII
3PA0CDS0M5
InChIKey
RGUQWGXAYZNLMI-UHFFFAOYSA-N
InChI
InChI=1S/C8H6F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-3H,(H,13,14)(H2,12,15,16)
SMILES (canonical and isomeric)
C1=C(C(=CC2=C1NC=NS2(=O)=O)S(=O)(=O)N)C(F)(F)F

Synonyms

  • Ademol
  • Trifluoromethylthiazide
  • Flumethiazid
  • Flumetiazid
  • Fludemil
  • Routrax
  • Ademil
  • Flumetiazida
  • Flumethiazidum
  • Flumetiazide
  • Trifluoromethyl thiazide
  • 6-(Trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • 6-Trifluoromethyl-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide
  • 6-Trifluoromethyl-7-sulfamoyl-4H-1,2,4-benzothiadiazine 1,1-dioxide
  • 7-Sulfamoyl-6-trifluoromethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
  • 10,10-dioxo-4-(trifluoromethyl)-10-lamda6-thia-7,9-diazabicyclo(4.4.0)deca-2,4,8,11-tetraene-3-sulfonamide
  • Trifluomethylthiazide
  • 4H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
  • Flumethiazide (INN)
  • 1,1-dioxo-6-(trifluoromethyl)-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
  • Flumethazide
  • 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
  • Ademol (TN)
  • 6-Trifluoromethyl-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
  • 6-(Trifluoromethyl)-1,2,4-benzo-thiadiazine-7-sulfonamide 1,1-dioxide
Show all 28 synonyms
  • 6-(Trifluoromethyl)-1,4,2-benzothiadiazine-7-sulfonamido 1,1-dioxide
  • 6-Trifluoromethyl-7-sulfamoyl-4H-1,4,2-benzothiadiazine 1,1-dioxide
  • 1,1-dioxo-6-(trifluoromethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Solubility
SPARINGLY SOL IN WATER, 50 MG/ML IN BOILING WATER WITH DECOMP, PRACTICALLY INSOL IN ETHYL ACETATE, METHYL ETHYL KETONE, BENZENE, TOLUENE, SOL IN METHANOL, ETHANOL, DIMETHYL FORMAMIDEexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
329.28 g/molcalc.
Exact mass
328.9752 Dacalc.
LogP (octanol/water)
0.5calc.
Topological polar surface area
118.7 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
20calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=S1(=O)N=CNc2ccccc21

O=S1(=O)N=CNc2ccccc21

2 rings, 12 atoms, the 4H-1,2,4-Benzothiadiazine, 1,1-dioxide ring system.

268 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Flumethiazide suppliers

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Flumethiazide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Carbonic anhydrase inhibitor.

How it is made

Holdredge et al, j am chem soc 81, 4807 (1959), yale et al, ibid, 82, 2042 (1960), us patent 3,040,042 (1962 to olin mathieson), british patent 861,809 (1961 to sk&f).

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Flumethiazide is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Flumethiazide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Flumethiazide, based on the data on this page

What is Flumethiazide?

Flumethiazide is a benzothiadiazine.

What is the CAS number of Flumethiazide?

The CAS registry number of Flumethiazide is 148-56-1.

What is the molecular formula and weight of Flumethiazide?

The molecular formula of Flumethiazide is C8H6F3N3O4S2 and its molar mass is 329.28 g/mol.

What is Flumethiazide used for?

Carbonic anhydrase inhibitor.

Is Flumethiazide hazardous?

No GHS hazard classification for Flumethiazide is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Flumethiazide?

Flumethiazide is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Flumethiazide?

Post a free request on CompoundList and suppliers of Flumethiazide will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Flumethiazide?

Suppliers quote Flumethiazide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Flumethiazide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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