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Respiratory, allergy and digestive drugs

Fluticasone

Also known as Fluticasona, Fluticasonum, Fluticaps

CAS 90566-53-3Formula C22H27F3O4SMolar mass 444.52 g/molEC 892-507-6
GHS signal word: Warning. Pictograms: Harmful or irritant 47 suppliers listed Drug substance
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Fluticasone chemical structure, C22H27F3O4S, CAS 90566-53-3
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
90566-53-3
Formula
C22H27F3O4S
Molar mass
444.52 g/mol
EC number
892-507-6
HS code
293722
Category
Respiratory, allergy and digestive drugs

What is Fluticasone?

Plain description, key identifiers and synonyms

Fluticasone is a trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis. It has a role as an anti-asthmatic drug and an anti-allergic agent. It is a 17alpha-hydroxy steroid, an 11beta-hydroxy steroid, a 3-oxo-Delta(4) steroid, a fluorinated steroid, a corticosteroid and a thioester. It derives from a hydride of an androstane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate
CAS number
90566-53-3 CAS number cross-checked
EC number
892-507-6
Molecular formula
C22H27F3O4S
UNII
CUT2W21N7U
InChIKey
MGNNYOODZCAHBA-GQKYHHCASA-N
InChI
InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1
Canonical SMILES
CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)SCF
Isomeric SMILES
C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)SCF)O)C)O)F)C)F

Synonyms

  • Fluticasona
  • Fluticasonum
  • Fluticaps
  • Optinose
  • Opn-375
  • S-(fluoromethyl) (6alpha,11beta,16alpha,17alpha)-6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioate
  • HFA, Flovent
  • Propionate, Fluticasone
  • Flunase
  • Fluticaps (TN)
  • Fluticasone (INN)
  • Fluticasone?
  • Fluticasone, topical
  • Fluticasone Solution in Methanol, 100ug/mL
  • US11554172, Compound Fluticasone-Propionate
  • Androsta-1,4-diene-17-carbothioic acid, 6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxo-, S-(fluoromethyl) ester, (6alpha,11beta,16alpha,17alpha)-
  • S-(Fluoromethyl) (6alpha,11beta,16alpha,17.alpha.)-6,9-difluoro-11,17-dihydroxy-16-methyl-3-oxoandrosta-1,4-diene-17-carbothioate
  • S-Fluoromethyl 6alpha,9-difluoro-11beta,17alpha-dihydroxy-16alpha-methyl-3-oxoandrosta-1,4-diene-17beta-carbothioate

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
444.52 g/molcalc.
Exact mass
444.1582 Dacalc.
LogP (octanol/water)
3.47calc.
Topological polar surface area
74.6 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
30calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.73calc.
Formal charge
0calc.
Stereocentres
9calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

4 rings, 18 atoms.

956 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H332Harmful if inhaled.
Precautionary statements (17)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P317Get medical help.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Fluticasone suppliers

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All 47 suppliers
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Where suppliers are based

47 suppliers in 13 countries

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Fluticasone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Relieve inflammatory and pruritic symptoms of dermatoses and psoriases, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma (Fluticasone propionate).

Fluticasone propionate is claimed to exert a topical effect on the lungs without significant systemic effects, due to its low systemic bioavailability. (Fluticasone propionate).

Therapeutic category: Antiallergic, antiasthmatic, anti-inflammatory (Fluticasone propionate).

Pharmacological actions

  • Anti-Allergic Agents
  • Anti-Inflammatory Agents
  • Bronchodilator Agents
  • Dermatologic Agents

Roles

  • agonist
  • androgen
  • anti-allergic agent
  • anti-asthmatic agent
  • anti-asthmatic drug
  • hormone
  • hypoglycemic agent
  • molecular messenger
  • pharmaceutical
  • sex hormone

Pharmacology

Fluticasone is a Corticosteroid. The mechanism of action of fluticasone is as a Corticosteroid Hormone Receptor Agonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Fluticasone is traded under.

HS 2937.22Indicative HS code

Halogenated derivatives of corticosteroidal hormones

World exports in 2024
$1.65B
−29.3% vs 2023, imports $1.67B
2019 to 2024
Top exporters
  1. United Kingdom69.1%
  2. Italy7.8%
  3. Singapore5.6%
Top importers
  1. United States64.5%
  2. Spain5.1%
  3. United Kingdom3.7%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Fluticasone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Fluticasone, based on the data on this page

What is Fluticasone?

Fluticasone is a trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis. It has a role as an anti-asthmatic drug and an anti-allergic agent.

What is the CAS number of Fluticasone?

The CAS registry number of Fluticasone is 90566-53-3.

What is the molecular formula and weight of Fluticasone?

The molecular formula of Fluticasone is C22H27F3O4S and its molar mass is 444.52 g/mol.

What is Fluticasone used for?

Relieve inflammatory and pruritic symptoms of dermatoses and psoriases, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma (Fluticasone propionate).

Is Fluticasone hazardous?

Fluticasone carries the GHS signal word "Warning". Main hazards: harmful if swallowed, harmful in contact with skin, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Fluticasone?

Fluticasone is usually classified under HS code 293722 (Halogenated derivatives of corticosteroidal hormones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Fluticasone?

CompoundList lists 47 suppliers of Fluticasone in China, United States, India, Canada and 9 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Fluticasone in India?

8 suppliers in India list Fluticasone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Fluticasone?

Suppliers quote Fluticasone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Fluticasone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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