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Hormones and steroids

Diflorasone

Also known as Diflorasonum, Diflorasona, Murode

CAS 2557-49-5Formula C22H28F2O5Molar mass 410.46 g/molEC 219-875-7
GHS signal word: Warning. Pictograms: Harmful or irritant, Serious health hazard 12 suppliers listed Drug substance
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Diflorasone chemical structure, C22H28F2O5, CAS 2557-49-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
2557-49-5
Formula
C22H28F2O5
Molar mass
410.46 g/mol
EC number
219-875-7
HS code
293722
Category
Hormones and steroids

What is Diflorasone?

Plain description, key identifiers and synonyms

Diflorasone is the 16beta-analogue of flumethasone. It is used as the 17,21-diacetate as a topical anti-inflammatory and antipruritic in the treatment of various skin disorders. It has a role as an anti-inflammatory drug. It is a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a glucocorticoid, a 17alpha-hydroxy steroid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid and a 3-oxo-Delta(1),Delta(4)-steroid. It derives from a hydride of a pregnane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6S,8S,9R,10S,11S,13S,14S,16S,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS number
2557-49-5 CAS number cross-checked
EC number
219-875-7
Molecular formula
C22H28F2O5
UNII
T2DHJ9645W
MDL number
MFCD00200358
InChIKey
WXURHACBFYSXBI-XHIJKXOTSA-N
InChI
InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1
Canonical SMILES
CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3(F)C(O)CC2(C)C1(O)C(=O)CO
Isomeric SMILES
C[C@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C)F

Synonyms

  • Diflorasonum
  • Diflorasona
  • Murode
  • 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
  • (6alpha,11beta,16beta)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • Diflorasone (INN)
  • Murode (TN)
  • Diflorasone (Standard)
  • Diflorasone Solution in Acetonitrile, 100ug/mL
  • Diflorasone Solution in Acetonitrile, 1000ug/mL
  • 6?,9-Difluoro-11?,17,21-trihydroxy-16?-methy
  • (6?,11?,16?)-6,9-Difluoro-11,17,21-trihydroxy-16-methyl-pregna-1,4-diene-3,20-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
410.46 g/molcalc.
Exact mass
410.1905 Dacalc.
LogP (octanol/water)
1.84calc.
Topological polar surface area
94.83 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
29calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.73calc.
Formal charge
0calc.
Stereocentres
9calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

4 rings, 18 atoms.

956 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H312Harmful in contact with skin.
  • H319Causes serious eye irritation.
  • H361Suspected of damaging fertility or the unborn child.
  • H371May cause damage to organs.
Precautionary statements (16)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P308 + P316If exposed or concerned: Get emergency medical help immediately.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Diflorasone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 12 suppliers
12 of 12 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

12 suppliers in 4 countries

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Diflorasone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Anti-Inflammatory Agents
  • Glucocorticoids

Roles

  • anti-inflammatory agent
  • anti-inflammatory drug
  • pharmaceutical

Pharmacology

Diflorasone is a Corticosteroid. The mechanism of action of diflorasone is as a Corticosteroid Hormone Receptor Agonist.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Diflorasone is traded under.

HS 2937.22Indicative HS code

Halogenated derivatives of corticosteroidal hormones

World exports in 2024
$1.65B
−29.3% vs 2023, imports $1.67B
2019 to 2024
Top exporters
  1. United Kingdom69.1%
  2. Italy7.8%
  3. Singapore5.6%
Top importers
  1. United States64.5%
  2. Spain5.1%
  3. United Kingdom3.7%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Diflorasone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Diflorasone, based on the data on this page

What is Diflorasone?

Diflorasone is the 16beta-analogue of flumethasone. It is used as the 17,21-diacetate as a topical anti-inflammatory and antipruritic in the treatment of various skin disorders. It has a role as an anti-inflammatory drug.

What is the CAS number of Diflorasone?

The CAS registry number of Diflorasone is 2557-49-5.

What is the molecular formula and weight of Diflorasone?

The molecular formula of Diflorasone is C22H28F2O5 and its molar mass is 410.46 g/mol.

What is Diflorasone used for?

Known uses and roles of Diflorasone include anti-inflammatories in pharmaceuticals, hormones and steroids in pharmaceuticals, anti-inflammatory agent, anti-inflammatory drug, pharmaceutical and 2 more.

Is Diflorasone hazardous?

Diflorasone carries the GHS signal word "Warning". Main hazards: harmful in contact with skin, causes serious eye irritation, suspected of damaging fertility or the unborn child. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Diflorasone?

Diflorasone is usually classified under HS code 293722 (Halogenated derivatives of corticosteroidal hormones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Diflorasone?

CompoundList lists 12 suppliers of Diflorasone in China, United States, Czech Republic and India. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Diflorasone in India?

1 supplier in India list Diflorasone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Diflorasone?

Suppliers quote Diflorasone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Diflorasone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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