Foscarnet
Also known as Phosphonoformic acid, Phosphonoformate, Carboxyphosphonic acid
Key facts
What buyers check first
- CAS number
- 4428-95-9
- Formula
- CH3O5P
- Molar mass
- 126.00 g/mol
- EC number
- 112-287-0
- HS code
- 293149
- Category
- Antibiotics and anti-infectives
What is Foscarnet?
Plain description, key identifiers and synonyms
Phosphonoformic acid is phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity. It has a role as a geroprotector, an antiviral drug, a HIV-1 reverse transcriptase inhibitor and a sodium-dependent Pi-transporter inhibitor. It is a member of phosphonic acids, a carboxylic acid and a one-carbon compound. It is functionally related to a formic acid and a phosphonic acid. It is a conjugate acid of a phosphonatoformate and a phosphonoformate(2-).
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- phosphonoformic acid
- CAS number
- 4428-95-9 CAS number cross-checkedOther or deprecated CAS: 63585-09-1
- EC number
- 112-287-0
- Molecular formula
- CH3O5P
- UNII
- 364P9RVW4X
- InChIKey
- ZJAOAACCNHFJAH-UHFFFAOYSA-N
- InChI
- InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6)
- SMILES (canonical and isomeric)
- C(=O)(O)P(=O)(O)O
Synonyms
- Phosphonoformic acid
- Phosphonoformate
- Carboxyphosphonic acid
- phosphonocarboxylic acid
- Foscarmet
- phosphonomethanoic acid
- Phosphinecarboxylic acid, dihydroxy-, oxide
- Dihydroxyphosphinecarboxylic acid oxide
- dihydroxyphosphanecarboxylic acid oxide
- Phgosphonocarboxylic acid
- Formic acid, phosphono-
- Forscarnet
- 1nki
- Foscarnet (PFA)
- Phosphinecarboxylic acid, 1,1-dihydroxy-, 1-oxide, sodium salt (1:3)
- PFA & rIFNalphaA
- phosphonoformic acid(PFA)
- MSL & PFA
- Phosphono-formic acid(PFA)
- hydroxycarbonylphosphonic acid
- Foscarnet & IFN-alpha
- DivK1c_000915
- Foscarnet, Phosphonoformic Acid
- Phosphonoformic acid & IFN-alpha
- (PFA)dihydroxyphosphinecarboxylic acid oxide
Show all 29 synonymsShow fewer synonyms
- dihydroxyphosphinecarboxylic acid oxide(PFA)
- Dihydroxy(oxo)-lambda~5~-phosphanecarboxylic acid
- Phosphonoformate(trisodium) & Recombinant Alpha-A Interferon
- Dihydroxyphosphinecarboxylic acid oxide and MSL, neutralizing monoclonal antibody
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 126.00 g/molcalc.Computed value |
|---|---|
| Exact mass | 125.9718 Dacalc.Computed value |
| LogP (octanol/water) | -0.16calc.Computed value |
| Topological polar surface area | 94.83 Ųcalc.Computed value |
| Hydrogen bond donors | 3calc.Computed value |
| Hydrogen bond acceptors | 2calc.Computed value |
| Rotatable bonds | 1calc.Computed value |
| Heavy atoms | 7calc.Computed value |
| Rings | 0calc.Computed value |
| Aromatic rings | 0calc.Computed value |
| Fraction sp3 carbons | 0calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 0calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Safety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H341Suspected of causing genetic defects.
- H373May cause damage to organs through prolonged or repeated exposure.
Precautionary statements (7)
- P203Obtain, read and follow all safety instructions before use.
- P260Do not breathe dust, fume, gas, mist, vapours or spray.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P318If exposed or concerned, get medical advice.
- P319Get medical help if you feel unwell.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidFoscarnet suppliers
Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings
- Price on request
- United States, San DiegoUnclaimed profileFoscarnetGrade, purity and minimum order on requestPrice on request
- United States, San DiegoUnclaimed profileFoscarnetGrade, purity and minimum order on requestPrice on request
- Germany, LorrachUnclaimed profileFoscarnetGrade, purity and minimum order on requestPrice on request
- United States, HolbrookUnclaimed profileFoscarnetGrade, purity and minimum order on requestPrice on request
- Price on request
- United States, New YorkUnclaimed profileFoscarnetGrade, purity and minimum order on requestPrice on request
- China, GuangzhouUnclaimed profileFoscarnetGrade, purity and minimum order on requestPrice on request
Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.
Where suppliers are based
21 suppliers in 6 countries
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Foscarnet price
Indicative price range per kg from live supplier offers
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Uses and applications
What the substance is used for, by industry and function
Industries and functions
Pharmacological actions
- Antiviral Agents
- Reverse Transcriptase Inhibitors
Roles
- HIV-1 reverse transcriptase inhibitor
- anti-HIV agent
- anti-HIV-1 agent
- antiinfective agent
- antimicrobial agent
- antimicrobial drug
- antiviral agent
- antiviral drug
- enzyme inhibitor
- geroprotector
- pharmaceutical
- protective agent
- sodium-dependent Pi-transporter inhibitor
Pharmacology
Foscarnet is a Pyrophosphate Analog DNA Polymerase Inhibitor. The mechanism of action of foscarnet is as a DNA Polymerase Inhibitor and Chelating Activity.
How it is made
Phosphonoformate is prepared by saponification of the triethyl ester of phosphonoformate with NaOH. Trisodium phosphonoformate hexahydrate is recrystallized from H2O.
Regulatory status
Inventories, regulations and trade controls that list this substance
Health and food
- Active ingredient in FDA approved drug labels
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Foscarnet is traded under.
Non-halogenated organo-phosphorous derivatives, other
- China54.9%
- United States25.4%
- Germany5.1%
- United States20.9%
- Argentina14.9%
- Brazil14.3%
The HS code shown for Foscarnet is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Salt and hydrate forms
Records that share this compound as their parent
Same formula isomers
Different compounds that share this molecular formula
Frequently asked questions
Quick answers about Foscarnet, based on the data on this page
What is Foscarnet?
What is the CAS number of Foscarnet?
What is the molecular formula and weight of Foscarnet?
What is Foscarnet used for?
Is Foscarnet hazardous?
What is the HS code of Foscarnet?
Where can I buy Foscarnet?
What is the price of Foscarnet?
Guides for buyers
Practical guides that help when you source, ship or handle Foscarnet
- Article, QualityPharma grades explained: IP vs BP vs USP vs EPWhat the Indian, British, US and European pharmacopoeias are, how their monographs differ, what multi grade claims mean and why a grade alone does not make a product fit for medicines.Read
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
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