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Cardiovascular and metabolic drugs

Furosemide

Also known as Frusemide, Lasix, Furanthril

CAS 54-31-9Formula C12H11ClN2O5SMolar mass 330.75 g/molEC 200-203-6
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 164 suppliers listed Drug substance
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Furosemide chemical structure, C12H11ClN2O5S, CAS 54-31-9
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals from aqueous ethanol
Melting point
206 °C
Solubility
The sodium salt can be recrystallized from water, the solubility of the salt in water at…
HS code
293590
Category
Cardiovascular and metabolic drugs
Illustrative photo, a shrink wrapped pallet of kraft paper sacks in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Furosemide?

Plain description, key identifiers and synonyms

Furosemide is a chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure. It has a role as a xenobiotic, a loop diuretic and an environmental contaminant. It is a chlorobenzoic acid, a member of furans and a sulfonamide.

Furosemide is a medication used to treat fluid build-up due to heart failure, liver scarring, or kidney disease.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid
CAS number
54-31-9 CAS number cross-checked
EC number
200-203-6
Molecular formula
C12H11ClN2O5S
UNII
7LXU5N7ZO5
MDL number
MFCD00010549
InChIKey
ZZUFCTLCJUWOSV-UHFFFAOYSA-N
InChI
InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)
SMILES (canonical and isomeric)
C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl

Synonyms

  • Frusemide
  • Lasix
  • Furanthril
  • Furosemid
  • Errolon
  • Seguril
  • Transit
  • Aisemide
  • Beronald
  • Desdemin
  • Eutensin
  • Frusemin
  • Fuluvamide
  • Furanthryl
  • Furantril
  • Furesis
  • Fursemide
  • Lasilix
  • Lowpstron
  • Macasirool
  • Prefemin
  • Radonna
  • Rosemide
  • Trofurit
  • Fulsix
Show all 39 synonyms
  • Katlex
  • Lasex
  • Frusetic
  • Fursemid
  • Logirene
  • Marsemide
  • Frusid
  • Mirfat
  • Oedemex
  • Furosedon
  • Urosemide
  • Aluzine
  • Dryptal
  • Frusemid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystals from aqueous ethanolexp.
Odour
Odorlessexp.
Taste
Practically tastelessexp.
Melting point
206 °Cexp.
Solubility
The sodium salt can be recrystallized from water, the solubility of the salt in water at room temperature is 6%. /Furosemide sodium salt/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
330.75 g/molcalc.
Exact mass
330.0077 Dacalc.
LogP (octanol/water)
1.89calc.
Topological polar surface area
122.6 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
5calc.
Heavy atoms
21calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.08calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(NCc2ccco2)cc1

c1ccc(NCc2ccco2)cc1

2 rings, 13 atoms, the N-[(Furan-2-yl)methyl]aniline ring system.

294 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
  • H351Suspected of causing cancer.
  • H360May damage fertility or the unborn child.
  • H361Suspected of damaging fertility or the unborn child.
Precautionary statements (18)
  • P203Obtain, read and follow all safety instructions before use.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Furosemide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 164 suppliers
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Where suppliers are based

164 suppliers in 28 countries

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Furosemide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Diuretics, Sodium Potassium Chloride Symporter Inhibitors.

Furosemide has been used empirically and has been legally approved for many years by the US racing industry for the control of exercise-induced pulmonary haemorrhage (EIPH) or bleeding.

Veterinary medication:.

Use classes: Pharmaceuticals, Animal Drugs.

Industries and functions

Pharmacological actions

  • Diuretics
  • Sodium Potassium Chloride Symporter Inhibitors

Roles

  • anti-anaemic agent
  • antiatherosclerotic agent
  • antifibrotic agent
  • antihypertensive agent
  • antineoplastic agent
  • antipsychotic agent
  • cardiovascular drug
  • central nervous system depressant
  • central nervous system drug
  • diuretic
  • environmental contaminant
  • hepatoprotective agent
  • hypoglycemic agent
  • loop diuretic
  • pharmaceutical
  • protective agent
  • psychotropic drug
  • renoprotective agent
  • tranquilizing drug
  • xenobiotic

Functional uses

  • Pharmaceutical

Pharmacology

Furosemide is a Loop Diuretic. The physiologic effect of furosemide is by means of Increased Diuresis at Loop of Henle.

How it is made

2,4-Dichlorobenzoic acid is heated with chlorosulfonic acid, and the resulting 5-chlorosulfonyl derivative is reacted with concentrated ammonia to convert it to the 5-sulfamoyl analogue (I). Refluxing I with furfurylamine in large excess or in the presence of sodium bicarbonate yields crude furosemide, which is recrystallized from aqueous ethanol.

Produced by treatment of 2,4-dichloro-5-sulfamoylbenzoic acid with excess furfurylamine in the absence of solvent at 120-130 °C.

Preparation: K. Sturm et al., Germany patent 1122541, eidem United States of America patent 3058882 (both 1962 to Hoechst)

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Furosemide is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Furosemide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Furosemide, based on the data on this page

What is Furosemide?

Furosemide is a chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure. It has a role as a xenobiotic, a loop diuretic and an environmental contaminant.

What is the CAS number of Furosemide?

The CAS registry number of Furosemide is 54-31-9.

What is the molecular formula and weight of Furosemide?

The molecular formula of Furosemide is C12H11ClN2O5S and its molar mass is 330.75 g/mol.

What is Furosemide used for?

Diuretics, Sodium Potassium Chloride Symporter Inhibitors. Furosemide has been used empirically and has been legally approved for many years by the US racing industry for the control of exercise-induced pulmonary haemorrhage (EIPH) or bleeding. Veterinary medication:. Use classes: Pharmaceuticals, Animal Drugs.

Is Furosemide hazardous?

Furosemide carries the GHS signal word "Danger". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Furosemide?

Furosemide is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Furosemide?

CompoundList lists 164 suppliers of Furosemide in India, United States, China, Germany and 24 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Furosemide in India?

40 suppliers in India list Furosemide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Furosemide?

Suppliers quote Furosemide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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