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Alkaloids

(+)-Glaucine

Also known as Glaucine, Bromcholitin, (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline

CAS 475-81-0Formula C21H25NO4Molar mass 355.43 g/molEC 207-501-5
GHS signal word: Warning. Pictograms: Harmful or irritant 7 suppliers listed
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(+)-Glaucine chemical structure, C21H25NO4, CAS 475-81-0
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
475-81-0
Formula
C21H25NO4
Molar mass
355.43 g/mol
EC number
207-501-5
HS code
293979
Category
Alkaloids

What is (+)-Glaucine?

Plain description, key identifiers and synonyms

(S)-glaucine is an aporphine alkaloid that is (S)-1,2,9,10-tetrahydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in which the four phenolic hydrogens have been replaced by methyl groups. It has a role as an antibacterial agent, an antineoplastic agent, a platelet aggregation inhibitor, an antitussive, a muscle relaxant, a NF-kappaB inhibitor, a plant metabolite and a rat metabolite. It is an aporphine alkaloid, an organic heterotetracyclic compound, a polyether and a tertiary amino compound. It is a conjugate base of a (S)-glaucine(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
CAS number
475-81-0 CAS number cross-checked
EC number
207-501-5
Molecular formula
C21H25NO4
UNII
NU19306XA7
INCI name
GLAUCINE
InChIKey
RUZIUYOSRDWYQF-HNNXBMFYSA-N
InChI
InChI=1S/C21H25NO4/c1-22-7-6-12-9-18(25-4)21(26-5)20-14-11-17(24-3)16(23-2)10-13(14)8-15(22)19(12)20/h9-11,15H,6-8H2,1-5H3/t15-/m0/s1
Canonical SMILES
COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1C(C2)N(C)CC3
Isomeric SMILES
CN1CCC2=CC(=C(C3=C2[C@@H]1CC4=CC(=C(C=C43)OC)OC)OC)OC

Synonyms

  • Glaucine
  • Bromcholitin
  • (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
  • (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo(de,g)quinoline
  • 5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo(de,g)quinoline
  • d-Glaucine
  • Boldine dimethyl ether
  • Glauvent
  • S-(+)-Glaucine
  • Glaucine fumarate
  • 1,2,9,10-tetramethoxyaporphine
  • 1,2,9,10-Tetramethoxy-6a-alpha-aporphine
  • (S)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
  • Glaucine, d
  • (S)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo(de,g)quinoline
  • 4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-, (S)-
  • Tusidil (TN)
  • Boldine dimethylether
  • Glaucine (Standard)
  • Glaucine,(d)
  • O,O-Dimethylisoboldine, S-(+)-Glaucine, NSC 34396
  • 6aalpha-Aporphine, 1,2,9,10-tetramethoxy-
  • (S)-5,6,6a7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo(de,g)quinoline
  • Glaucine, S-(+)-Glaucine
  • 6a-alpha-APORPHINE, 1,2,9,10-TETRAMETHOXY-
Show all 33 synonyms
  • Glaucined-Glaucine, Bromcholitin, Glauvent
  • 6aalpha-Aporphine,2,9,10-tetramethoxy-
  • (s)-(+)-1,2,9,10-tetramethoxyaporphine
  • 1,2,9,10-TetramethoxyaporphineBoldine dimethyletherGlaucine
  • (6aS)-12910-Tetramethoxy-6-methyl-566a7-tetrahydro-4H-dibenzo[deg]quinoline
  • (6aS,11aM)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
  • 4H-Dibenzo[de, 5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-, (S)-
  • (6As)-5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo(de,g)quinoline

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
355.43 g/molcalc.
Exact mass
355.1784 Dacalc.
LogP (octanol/water)
3.47calc.
Topological polar surface area
40.16 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
4calc.
Heavy atoms
26calc.
Rings
4calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc2c(c1)CC1NCCc3cccc-2c31

c1ccc2c(c1)CC1NCCc3cccc-2c31

4 rings, 17 atoms.

289 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

(+)-Glaucine suppliers

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Where suppliers are based

7 suppliers in 2 countries

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(+)-Glaucine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name GLAUCINE(skin conditioning)

Pharmacological actions

  • Antioxidants
  • Antitussive Agents
  • Parasympatholytics

Roles

  • NF-kappaB inhibitor
  • animal metabolite
  • antibacterial agent
  • antimicrobial agent
  • antineoplastic agent
  • antitussive
  • eukaryotic metabolite
  • hematologic agent
  • mammalian metabolite
  • metabolite
  • muscle relaxant
  • neuromuscular agent
  • pharmaceutical
  • plant metabolite
  • platelet aggregation inhibitor
  • rat metabolite

Functional uses

  • Softener and conditioner

Cosmetic functions

  • Skin conditioning

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (+)-Glaucine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (+)-Glaucine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (+)-Glaucine, based on the data on this page

What is (+)-Glaucine?

(S)-glaucine is an aporphine alkaloid that is (S)-1,2,9,10-tetrahydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in which the four phenolic hydrogens have been replaced by methyl groups.

What is the CAS number of (+)-Glaucine?

The CAS registry number of (+)-Glaucine is 475-81-0.

What is the molecular formula and weight of (+)-Glaucine?

The molecular formula of (+)-Glaucine is C21H25NO4 and its molar mass is 355.43 g/mol.

What is (+)-Glaucine used for?

Known uses and roles of (+)-Glaucine include skin conditioning agents in cosmetics and personal care, nf-kappab inhibitor, animal metabolite, antibacterial agent, antimicrobial agent and 17 more.

Is (+)-Glaucine hazardous?

(+)-Glaucine carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of (+)-Glaucine?

(+)-Glaucine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (+)-Glaucine?

CompoundList lists 7 suppliers of (+)-Glaucine in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of (+)-Glaucine?

Suppliers quote (+)-Glaucine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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