Grapiprant (CAS 415903-37-6): price, suppliers and safety

What is Grapiprant?

Plain description, key identifiers and synonyms

Grapiprant is an orally bioavailable antagonist of the prostaglandin E receptor subtype 4 (EP4), with potential analgesic, immunomodulating and antineoplastic activities. Upon administration of grapiprant, this agent selectively binds to and inhibits the binding of prostaglandin E2 (PGE2) and prevents the activation of the EP4 receptor. This inhibits PGE2-EP4 receptor-mediated signaling and prevents proliferation in tumor cells in which the PGE2-EP4 signaling pathway is over-activated. In addition, EP4 receptor inhibition modulates the immune system by preventing both interleukin-23 (IL-23) production and the IL-23-mediated expansion of Th17 cells. As EP4 is expressed by peripheral sensory neurons, blockade of EP4-mediated signaling may induce an analgesic effect. EP4, a prostanoid receptor subtype, is a G protein-coupled receptor that is expressed in certain types of cancers, it promotes tumor cell proliferation and invasion.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name: 1-[2-[4-(2-ethyl-4,6-dimethylimidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea
CAS number: 415903-37-6 CAS number cross-checked
EC number: 112-524-8
Molecular formula: C₂₆H₂₉N₅O₃S
UNII: J9F5ZPH7NB
MDL number: MFCD16628076
InChIKey: HZVLFTCYCLXTGV-UHFFFAOYSA-N
InChI: InChI=1S/C26H29N5O3S/c1-5-24-29-25-19(4)28-18(3)16-23(25)31(24)21-10-8-20(9-11-21)14-15-27-26(32)30-35(33,34)22-12-6-17(2)7-13-22/h6-13,16H,5,14-15H2,1-4H3,(H2,27,30,32)
SMILES (canonical and isomeric): CCC1=NC2=C(N1C3=CC=C(C=C3)CCNC(=O)NS(=O)(=O)C4=CC=C(C=C4)C)C=C(N=C2C)C

Synonyms

CJ 023423
CJ-023,423
1-[2-[4-(2-ethyl-4,6-dimethylimidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea
Benzenesulfonamide, N-(((2-(4-(2-ethyl-4,6-dimethyl-1H-imidazo(4,5-c)pyridin-1-yl)phenyl)ethyl)amino)carbonyl)-4-methyl-
1-(2-(4-(2-ethyl-4,6-dimethylimidazo(4,5-c)pyridin-1-yl)phenyl)ethyl)-3-(4-methylphenyl)sulfonylurea
grapiprantum
Galliprant
3-(2-(4-(2-ethyl-4,6-dimethyl-1H-imidazo(4,5-c)pyridin-1-yl)phenyl)ethyl)-1-(4-methylbenzenesulfonyl)urea
3-[2-(4-{2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl}phenyl)ethyl]-1-(4-methylbenzenesulfonyl)urea
CJ023,423
CJ 023,423
N-(((2-(4-(2-ethyl-4,6-dimethyl-1H-imidazo(4,5-c)pyridin-1-yl) phenyl)ethyl)amino)carbonyl)-4-methylbenzenesulfonamide
N-((2,4-(2-ethyl-4,6-dimethyl-1H-imidazo(4,5-c)pyridin-1-yl)phenylethylamino)carbonyl)-4-methyl-benzenesulfonamide
N-((4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenethyl)carbamoyl)-4-methylbenzenesulfonamide
CJ-023423 Hydrochloride Salt, Hydrate
Grapiprant (CJ-023,423)
N-[[[2-[4-(2-Ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]amino]carbonyl]-4-methylbenzenesulfonamide
CJ-023423, RQ-00000007, AAT-007
N-(((2-(4-(2-Ethyl-4,6-dimethyl-1H-imidazo(4,5-c)pyridin-1-yl)phenyl)ethyl)amino)carbonyl)-4-methyl-benzenesulfonamide
Grapiprant?
N-(((2-(4-(2-Ethyl-4,6-dimethyl-1H-imidazo(4,5-c)pyridin-1-yl)phenyl)ethyl)amino)carbonyl)-4-methylbenzenesulfonamide
N-[([2-[4-(2-Ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]amino)carbonyl]-4-methylbenzenesulfonamide
N-[[4-(2-Ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenethyl]carbamoyl]-4-methylbenzenesulfonamide
Grapiprant (USAN/INN)
N-((4-(2-ethyl-4,6-d

Show all 29 synonyms

Grapiprant, RQ-00000007, AAT-007, CJ-023423
1-[2-[4-(2-ethyl-4,6-dimethyl-imidazo[4,5-c]pyridin-1-yl)phenyl]ethyl]-3-(p-tolylsulfonyl)urea
1-[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea
2-Ethyl-4,6-dimethyl-1-(4-(2-(((((4-methylphenyl)sulfonyl)amino)carbonyl)amino)ethyl)phenyl)-1H-imidazo(4,5-c)pyridine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight	491.62 g/molcalc.
Exact mass	491.1991 Dacalc.
LogP (octanol/water)	4.14calc.
Topological polar surface area	106 Å²calc.
Hydrogen bond donors	2calc.
Hydrogen bond acceptors	5calc.
Rotatable bonds	7calc.
Heavy atoms	35calc.
Rings	4calc.
Aromatic rings	4calc.
Fraction sp3 carbons	0.27calc.
Formal charge	0calc.
Stereocentres	0calc.
Lipinski rule of five	Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

O=C(NCCc1ccc(-n2cnc3cnccc32)cc1)NS(=O)(=O)c1ccccc1

4 rings, 30 atoms.

1 other chemical share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word

Warning

Harmful or irritant

Hazard statements

H302Harmful if swallowed.

Precautionary statements (5)

P264Wash skin thoroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301 + P317If swallowed: Get medical help.
P330Rinse mouth.
P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Grapiprant suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 18 suppliers

Verified only18 of 18 offers

Pharmaids Pharmaceuticals Limited
India ManufacturerUnclaimed profile
GrapiprantGrade, purity and minimum order on request
Price on request
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Shanghaizehan biopharma technology co., Ltd
China, ShanghaiUnclaimed profile
GrapiprantGrade, purity and minimum order on request
Price on request
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Zhejiang Apeloa Jiayuan Pharmaceutical Co., Ltd.
China, Dongyang ManufacturerUnclaimed profile
GrapiprantGrade, purity and minimum order on request
Price on request
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Zenfold Sustainable Technologies Private Limited
India, Sangareddy ManufacturerUnclaimed profile
GrapiprantGrade, purity and minimum order on request
Price on request
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Sterling Pharma Solutions Limited
United Kingdom, Cramlington ManufacturerUnclaimed profile
GrapiprantGrade, purity and minimum order on request
Price on request
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AChemBlock
United States, HaywardUnclaimed profile
GrapiprantGrade, purity and minimum order on request
Price on request
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Angel Pharmatech Ltd.
China, ShanghaiUnclaimed profile
GrapiprantGrade, purity and minimum order on request
Price on request
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Ark Pharma Scientific Limited
China, WuhanUnclaimed profile
GrapiprantGrade, purity and minimum order on request
Price on request
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AvaChem Scientific LLC
United StatesUnclaimed profile
GrapiprantGrade, purity and minimum order on request
Price on request
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Axon Medchem
United States, RestonUnclaimed profile
GrapiprantGrade, purity and minimum order on request
Price on request
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

18 suppliers in 5 countries

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Grapiprant price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Use classes: Animal Drugs.

Roles

antineoplastic agent
pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Grapiprant is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024

$5.64B

−11.0% vs 2023, imports $8.56B

2019 to 2024

Top exporters

Ireland43.1%
China12.0%
India * partner reported9.5%

Top importers

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Grapiprant is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Parent and salt forms, stereoisomers, similar structures and isomers

Salt and hydrate forms

Records that share this compound as their parent

CJ-023423 Hydrochloride chemical structure, C26H30ClN5O3S, CAS 2408288-99-1

CJ-023423 Hydrochloride2408288-99-1C₂₆H₃₀ClN₅O₃S

Similar structures

Nearest neighbours by Morgan fingerprint Tanimoto similarity

tert-Butyl 4-(2-ethyl-4,6-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)phenethylcarbamate chemical structure, C23H30N4O2, CAS 2408731-76-8

Same formula isomers

Different compounds that share this molecular formula

All isomers

3,5-Dimethyl-4-{[2-({1-[4-(methylsulfonyl)benzyl]piperidin-4-yl}amino)pyrimidin-4-yl]oxy}benzonitrile chemical structure, C26H29N5O3S, CAS 1033950-94-5

3,5-Dimethyl-4-{[2-({1-[4-(methylsulfonyl)benzyl]piperidin-4-yl}amino)pyrimidin-4-yl]oxy}benzonitrile1033950-94-5C₂₆H₂₉N₅O₃S

N-(4-Butylphenyl)-2-(7-(furan-2-yl)-4-oxo-2-(piperidin-1-yl)thiazolo[4,5-d]pyridazin-5(4H)-yl)acetamide chemical structure, C26H29N5O3S, CAS 1105241-23-3

N-(4-Butylphenyl)-2-(7-(furan-2-yl)-4-oxo-2-(piperidin-1-yl)thiazolo[4,5-d]pyridazin-5(4H)-yl)acetamide1105241-23-3C₂₆H₂₉N₅O₃S

N-(2-Methoxybenzyl)-2,2-dimethyl-5-morpholin-4-yl-1,4-dihydro-2H-pyrano[4'''',3'''':4'',5'']thieno[3,2-d]pyrimidin-8-amine chemical structure, C26H29N5O3S, CAS 1247025-89-3

N-(2-Methoxybenzyl)-2,2-dimethyl-5-morpholin-4-yl-1,4-dihydro-2H-pyrano[4'''',3'''':4'',5'']thieno[3,2-d]pyrimidin-8-amine1247025-89-3C₂₆H₂₉N₅O₃S

5-(4-Benzylpiperazin-1-yl)-2-[4-(piperidine-1-sulfonyl)phenyl]-1,3-oxazole-4-carbonitrile chemical structure, C26H29N5O3S, CAS 941267-03-4

5-(4-Benzylpiperazin-1-yl)-2-[4-(piperidine-1-sulfonyl)phenyl]-1,3-oxazole-4-carbonitrile941267-03-4C₂₆H₂₉N₅O₃S

2-[4-(Azepan-1-ylsulfonyl)phenyl]-5-(4-phenylpiperazin-1-yl)-1,3-oxazole-4-carbonitrile chemical structure, C26H29N5O3S, CAS 940999-29-1

2-[4-(Azepan-1-ylsulfonyl)phenyl]-5-(4-phenylpiperazin-1-yl)-1,3-oxazole-4-carbonitrile940999-29-1C₂₆H₂₉N₅O₃S

2-{4-[(4-Methylpiperidin-1-yl)sulfonyl]phenyl}-5-(4-phenylpiperazin-1-yl)-1,3-oxazole-4-carbonitrile chemical structure, C26H29N5O3S, CAS 941000-26-6

2-{4-[(4-Methylpiperidin-1-yl)sulfonyl]phenyl}-5-(4-phenylpiperazin-1-yl)-1,3-oxazole-4-carbonitrile941000-26-6C₂₆H₂₉N₅O₃S

2-{4-[(3-Methylpiperidin-1-yl)sulfonyl]phenyl}-5-(4-phenylpiperazin-1-yl)-1,3-oxazole-4-carbonitrile chemical structure, C26H29N5O3S, CAS 941248-50-6

2-{4-[(3-Methylpiperidin-1-yl)sulfonyl]phenyl}-5-(4-phenylpiperazin-1-yl)-1,3-oxazole-4-carbonitrile941248-50-6C₂₆H₂₉N₅O₃S

1-(2-Methyl-5-((4-(6-(o-tolyl)pyridazin-3-yl)piperazin-1-yl)sulfonyl)indolin-1-yl)ethanone chemical structure, C26H29N5O3S, CAS 1049299-25-3

1-(2-Methyl-5-((4-(6-(o-tolyl)pyridazin-3-yl)piperazin-1-yl)sulfonyl)indolin-1-yl)ethanone1049299-25-3C₂₆H₂₉N₅O₃S

N-{[1-Cyclopentyl-5-(thiophen-2-yl)-1H-pyrazol-3-yl]methyl}-3-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide chemical structure, C26H29N5O3S, CAS 1421513-59-8

N-{[1-Cyclopentyl-5-(thiophen-2-yl)-1H-pyrazol-3-yl]methyl}-3-(2,5-dimethoxyphenyl)-1-methyl-1H-pyrazole-5-carboxamide1421513-59-8C₂₆H₂₉N₅O₃S

(4Z)-2,5-Bis(4-methoxyphenyl)-4-{1-[(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)amino]ethylidene}-2,4-dihydro-3H-pyrazol-3-one chemical structure, C26H29N5O3S, CAS 884422-98-4

(4Z)-2,5-Bis(4-methoxyphenyl)-4-{1-[(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)amino]ethylidene}-2,4-dihydro-3H-pyrazol-3-one884422-98-4C₂₆H₂₉N₅O₃S

2-Isopropyl-5-((2-(4-(2-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)thio)imidazo[1,2-c]quinazolin-3(2H)-one chemical structure, C26H29N5O3S, CAS 1053083-96-7

2-Isopropyl-5-((2-(4-(2-methoxyphenyl)piperazin-1-yl)-2-oxoethyl)thio)imidazo[1,2-c]quinazolin-3(2H)-one1053083-96-7C₂₆H₂₉N₅O₃S

2-{[7-(4-Ethoxyphenyl)-8-oxo-7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl]sulfanyl}-N-[4-(propan-2-yl)phenyl]butanamide chemical structure, C26H29N5O3S, CAS 1223901-72-1

2-{[7-(4-Ethoxyphenyl)-8-oxo-7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl]sulfanyl}-N-[4-(propan-2-yl)phenyl]butanamide1223901-72-1C₂₆H₂₉N₅O₃S

Frequently asked questions

Quick answers about Grapiprant, based on the data on this page

What is Grapiprant?

Grapiprant is an orally bioavailable antagonist of the prostaglandin E receptor subtype 4 (EP4), with potential analgesic, immunomodulating and antineoplastic activities.

What is the CAS number of Grapiprant?

The CAS registry number of Grapiprant is 415903-37-6.

What is the molecular formula and weight of Grapiprant?

The molecular formula of Grapiprant is C26H29N5O3S and its molar mass is 491.62 g/mol.

What is Grapiprant used for?

Use classes: Animal Drugs.

Is Grapiprant hazardous?

Grapiprant carries the GHS signal word "Warning". Main hazards: harmful if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Grapiprant?

Grapiprant is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Grapiprant?

CompoundList lists 18 suppliers of Grapiprant in China, United States, India, Canada and 1 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Grapiprant in India?

2 suppliers in India list Grapiprant on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Grapiprant?

Suppliers quote Grapiprant on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Grapiprant

Key facts

What is Grapiprant?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Grapiprant suppliers

Where suppliers are based

Send one request to many suppliers

Grapiprant price

Uses and applications

Roles

Regulatory status

Health and food

HS code and trade data

Global trade

Frequently asked questions

What is Grapiprant?

What is the CAS number of Grapiprant?

What is the molecular formula and weight of Grapiprant?

What is Grapiprant used for?

Is Grapiprant hazardous?

What is the HS code of Grapiprant?

Where can I buy Grapiprant?

Where can I buy Grapiprant in India?

What is the price of Grapiprant?

Guides for buyers

Get quotes for Grapiprant

Key facts

What is Grapiprant?

Identifiers

Synonyms

Physical and chemical properties

Physical and chemical properties

Computed descriptors

Murcko scaffold

Safety and hazards

Hazard statements

Grapiprant suppliers

Where suppliers are based

Send one request to many suppliers

Grapiprant price

Uses and applications

Roles

Regulatory status

Health and food

HS code and trade data

Global trade

Related chemicals

Salt and hydrate forms

Similar structures

Same formula isomers

Frequently asked questions

What is Grapiprant?

What is the CAS number of Grapiprant?

What is the molecular formula and weight of Grapiprant?

What is Grapiprant used for?

Is Grapiprant hazardous?

What is the HS code of Grapiprant?

Where can I buy Grapiprant?

Where can I buy Grapiprant in India?

What is the price of Grapiprant?

Guides for buyers

Get quotes for Grapiprant