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Cardiovascular and metabolic drugs

Guanethidine

Also known as Abapresin, Sanotensin, Eutensol

CAS 55-65-2Formula C10H22N4Molar mass 198.31 g/molEC 200-241-3
9 suppliers listed
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Guanethidine chemical structure, C10H22N4, CAS 55-65-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
55-65-2
Formula
C10H22N4
Molar mass
198.31 g/mol
Solubility
WHITE, CRYSTALLINE POWDER, STRONG CHARACTERISTIC ODOR, SPARINGLY SOL IN WATER, SLIGHTLY…
HS code
293399
Category
Cardiovascular and metabolic drugs

What is Guanethidine?

Plain description, key identifiers and synonyms

Guanethidine is a member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group. It has a role as an antihypertensive agent, an adrenergic antagonist and a sympatholytic agent. It is a member of guanidines and a member of azocanes. It is functionally related to a guanidine. It derives from a hydride of an azocane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-[2-(azocan-1-yl)ethyl]guanidine
CAS number
55-65-2 CAS number cross-checkedOther or deprecated CAS: 645-43-2
EC number
200-241-3
Molecular formula
C10H22N4
UNII
ZTI6C33Q2Q
MDL number
MFCD20542855
InChIKey
ACGDKVXYNVEAGU-UHFFFAOYSA-N
InChI
InChI=1S/C10H22N4/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14/h1-9H2,(H4,11,12,13)
SMILES (canonical and isomeric)
C1CCCN(CCC1)CCN=C(N)N

Synonyms

  • Abapresin
  • Sanotensin
  • Eutensol
  • Oktadin
  • Octatensine
  • Oktatensin
  • Oktatenzin
  • Dopom
  • Guanetidina
  • Octadine
  • Guanethidinum
  • 2-(1'-Azacyclooctyl)ethylguanidine
  • N-(2-Perhydroazocin-1-ylethyl)guanidine
  • Azocine, 1-(2-guanidinoethyl)octahydro-
  • 2-[2-(azocan-1-yl)ethyl]guanidine
  • 2-(1-N,N-Heptamethyleneimino)ethylguanidine
  • Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-
  • (2-(Octahydro-1-azocinyl)ethyl)guanidine
  • 1-[2-(azocan-1-yl)ethyl]guanidine
  • Heptamethylenimine, 1-(2-guanidinoethyl)-
  • 1-(2-(Azocan-1-yl)ethyl)guanidine
  • Azocine, 1-((2-(aminoiminomethyl)amino)ethyl)octahydro-
  • (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine
  • Guanidine, [2-(hexahydro-1(2H)-azocinyl)ethyl]-
  • [2-(Octahydro-1-azocinyl)ethyl]guanidine
Show all 38 synonyms
  • 2-(2-(azocan-1-yl)ethyl)guanidine
  • [2-(Hexahydro-1(2H)-azocinyl)ethyl]guanidine
  • Azocine, 1-[[2-(aminoiminomethyl)amino]ethyl]octahydro-
  • ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine
  • Ismelin
  • Dopam
  • Octatensin
  • Isobarin
  • Octadin
  • N-[2-(azocan-1-yl)ethyl]guanidine
  • Guanethidine (INN)
  • Guanetidin sulfate
  • 1-(2-azocan-1-ylethyl)guanidine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility
WHITE, CRYSTALLINE POWDER, STRONG CHARACTERISTIC ODOR, SPARINGLY SOL IN WATER, SLIGHTLY SOL IN ALC, PRACTICALLY INSOL IN CHLOROFORM /SULFATE/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
198.31 g/molcalc.
Exact mass
198.1844 Dacalc.
LogP (octanol/water)
0.53calc.
Topological polar surface area
67.64 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
14calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.9calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, C1CCCNCCC1

C1CCCNCCC1

1 ring, 8 atoms, the Azocan ring system.

185 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Guanethidine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 9 suppliers
9 of 9 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

9 suppliers in 4 countries

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Guanethidine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Use classes: Pharmaceuticals.

Industries and functions

Pharmacological actions

  • Adrenergic Agents
  • Antihypertensive Agents
  • Sympatholytics

Roles

  • adrenergic agent
  • adrenergic antagonist
  • antiglaucoma drug
  • antihypertensive agent
  • cardiovascular drug
  • neurotransmitter agent
  • ophthalmology drug
  • pharmaceutical
  • sympatholytic agent

How it is made

Maxwell et al, experientia 15, 267 (1959), mull, us patent 2,928,829 (1960 to ciba). Improved process: mull, us patents 3,006,916, 3,055,882 (1961, 1962 to ciba).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Guanethidine (INN) and its salts, Ref no: 259, Annex ref: II/259

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Guanethidine is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Guanethidine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Guanethidine, based on the data on this page

What is Guanethidine?

Guanethidine is a member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group. It has a role as an antihypertensive agent, an adrenergic antagonist and a sympatholytic agent. It is a member of guanidines and a member of azocanes.

What is the CAS number of Guanethidine?

The CAS registry number of Guanethidine is 55-65-2. Other or deprecated CAS numbers: 645-43-2.

What is the molecular formula and weight of Guanethidine?

The molecular formula of Guanethidine is C10H22N4 and its molar mass is 198.31 g/mol.

What is Guanethidine used for?

Use classes: Pharmaceuticals.

Is Guanethidine hazardous?

No GHS hazard classification for Guanethidine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Guanethidine?

Guanethidine is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Guanethidine?

CompoundList lists 9 suppliers of Guanethidine in China, United States, Hong Kong and Singapore. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Guanethidine?

Suppliers quote Guanethidine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Guanethidine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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