CompoundList
Sign in
Aldehydes and ketones

Hexafluoroacetone

Also known as Perfluoroacetone, Perfluoro-2-propanone, Acetone, hexafluoro-

CAS 684-16-2Formula C3F6OMolar mass 166.02 g/molEC 211-676-3
GHS signal word: Danger. Pictograms: Gas under pressure, Corrosive, Acute toxicity (severe), Harmful or irritant 11 suppliers listed
Get quotes Compare 11 suppliers
Hexafluoroacetone chemical structure, C3F6O, CAS 684-16-2
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless gas
Melting point
-125.5 °C
Boiling point
-27 °C
Density
1.33 G/ML @ 25 °C (LIQUID)
Solubility
Solubility in water: reaction, releasing heat
HS code
291479
Category
Aldehydes and ketones
UN number
UN 2420
Illustrative photo, a bundle of gas cylinders on a manifold in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Hexafluoroacetone?

Plain description, key identifiers and synonyms

Hexafluoroacetone is a ketone that is acetone in which all the methyl hydrogens are replaced by fluoro groups. It is a perfluorinated compound and a ketone.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1,1,1,3,3,3-hexafluoropropan-2-one
CAS number
684-16-2 CAS number cross-checked
EC number
211-676-3
Molecular formula
C3F6O
UNII
AKU9463N1Y
MDL number
MFCD00000422
InChIKey
VBZWSGALLODQNC-UHFFFAOYSA-N
InChI
InChI=1S/C3F6O/c4-2(5,6)1(10)3(7,8)9
SMILES (canonical and isomeric)
C(=O)(C(F)(F)F)C(F)(F)F

Synonyms

  • Perfluoroacetone
  • Perfluoro-2-propanone
  • Acetone, hexafluoro-
  • Hexafluoro-2-propanone
  • 1,1,1,3,3,3-Hexafluoro-2-propanone
  • GC 7887
  • 1,1,1,3,3,3-Hexafluoroacetone
  • 2-Propanone, 1,1,1,3,3,3-hexafluoro-
  • 1,1,1,3,3,3-hexafluoropropan-2-one
  • Hexafluoropropanone
  • (CF3)2CO
  • hexafluoropropan-2-one
  • hexafluor-oacetone
  • hexafluoro acetone
  • trifluoromethyl ketone
  • Hexafluoroacetone, 97%
  • CF3COCF3
  • Hexafluoroacetone [UN2420] [Poison gas]
  • 2-Propanone, hexafluoro-
  • Hexafluoroacetone, anhydrous
  • CF3C(O)CF3
  • 1,1,1,3,3,3-Hexafluoroacetone #
  • 1,1,3,3,3-Hexafluoro-2-propanone
  • UN 2420
  • 2-Propanone,1,1,3,3,3-hexafluoro-
Show all 27 synonyms
  • propanone, 1,1,1,3,3,3-hexafluoro-
  • 1,1,1,3,3,3-hexafluoro-propan-2-one

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless gasexp.
Odour
MUSTY ODOR BECOMES ACRID IN PRESENCE OF ACIDIC IMPURITIESexp.
Melting point
-125.5 °Cexp.
Boiling point
-27 °Cexp.
Density
1.33 G/ML @ 25 °C (LIQUID)exp.
Solubility
Solubility in water: reaction, releasing heatexp.
Vapour pressure
5.0 mm Hg @ 25 °C, from experimentally derived coefficientsexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
166.02 g/molcalc.
Exact mass
165.9853 Dacalc.
LogP (octanol/water)
1.68calc.
Topological polar surface area
17.07 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
1calc.
Rotatable bonds
0calc.
Heavy atoms
10calc.
Rings
0calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.67calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS04: Gas under pressure
Gas under pressure
GHS05: Corrosive
Corrosive
GHS06: Acute toxicity (severe)
Acute toxicity (severe)
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H280Contains gas under pressure, may explode if heated.
  • H301 + H311Toxic if swallowed. Toxic in contact with skin.
  • H301Toxic if swallowed.
  • H310Fatal in contact with skin.
  • H311Toxic in contact with skin.
  • H314Causes severe skin burns and eye damage.
  • H315Causes skin irritation.
  • H318Causes serious eye damage.
  • H330Fatal if inhaled.
  • H360May damage fertility or the unborn child.
  • H360FdMay damage fertility. Suspected of damaging the unborn child.
  • H370Causes damage to organs.

1 more on the safety page.

Precautionary statements (31)
  • P203Obtain, read and follow all safety instructions before use.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P262Do not get in eyes, on skin, or on clothing.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P316If swallowed: Get emergency medical help immediately.
  • P301 + P330 + P331If swallowed: Rinse mouth. Do not induce vomiting.
  • P302 + P352If on skin: Wash with plenty of water.
  • P302 + P361 + P354If on skin: Take off immediately all contaminated clothing. Immediately rinse with water for several minutes.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P354 + P338If in eyes: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P308 + P316If exposed or concerned: Get emergency medical help immediately.
  • P316Get emergency medical help immediately.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P320Specific treatment is urgent (see supplemental first aid instructions on the label).
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P363Wash contaminated clothing before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P410 + P403Protect from sunlight. Store in a well-ventilated place.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2420
Transport hazard class
2.3

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Hexafluoroacetone suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 11 suppliers
11 of 11 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

11 suppliers in 3 countries

Send one request to many suppliers

Choose up to 10 suppliers or let us match your request. Compare quotes side by side, free.

Choose suppliersPost a request

Hexafluoroacetone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Chemical intermediate for hexafluoroisopropanol, polyacrylates for textile coating & polyester coating for textiles, solvent for acetal resins & polyamides, polymer adhesive.

1,1,1,3,3,3-Hexafluoro-2-propanone is widely used in the synthesis of polymers, medicinals, agriculture chemicals, and as a component of high-performance fluoropolymers and in the manufacture of the solvent 1,1,1,3,3,3-hexafluoro-2-propanol.

1,1,1,3,3,3-Hexafluoro-2-propanone is employed in organic synthesis. It is also used as a chemical intermediate for hexafluoroisopropanol, polyacrylates used for textile coating, and polyester coating for textiles, a solvent for acetal resins and polyamides, and a polymer adhesive.

Industrial uses: Intermediate.

How it is made

1,1,1,3,3,3-Hexafluoro-2-propanone is prepared from acetone in low yield by direct fluorination

1,1,1,3,3,3-Hexafluoro-2-propanone is manufactured by perchlorination of acetone, followed by reaction with hydrogen fluoride and a chromium catalyst. Separation of the product from excess hydrogen fluoride requires the use of a hydrogen fluoride acceptor, such as activated sodium fluoride or acetic anhydride.

The rearrangement of hexafluoropropyleneoxide induced by Lewis acids is an attractive new route that avoids the highly toxic sym-dichlorotetrafluoro- and chloropentafluoroacetones.

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hexafluoroacetone is traded under.

HS 2914.79Indicative HS code

Halogenated, sulphonated, nitrated or nitrosated derivatives, other

World exports in 2024
$558M
−12.1% vs 2023, imports $608M
2019 to 2024
Top exporters
  1. China41.2%
  2. India * partner reported28.7%
  3. Germany16.7%
Top importers
  1. United States29.1%
  2. Italy9.9%
  3. Switzerland * partner reported8.8%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Hexafluoroacetone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hexafluoroacetone, based on the data on this page

What is Hexafluoroacetone?

Hexafluoroacetone is a ketone that is acetone in which all the methyl hydrogens are replaced by fluoro groups. It is a perfluorinated compound and a ketone.

What is the CAS number of Hexafluoroacetone?

The CAS registry number of Hexafluoroacetone is 684-16-2.

What is the molecular formula and weight of Hexafluoroacetone?

The molecular formula of Hexafluoroacetone is C3F6O and its molar mass is 166.02 g/mol.

What is Hexafluoroacetone used for?

Chemical intermediate for hexafluoroisopropanol, polyacrylates for textile coating & polyester coating for textiles, solvent for acetal resins & polyamides, polymer adhesive.

Is Hexafluoroacetone hazardous?

Hexafluoroacetone carries the GHS signal word "Danger". Main hazards: contains gas under pressure, may explode if heated, toxic if swallowed. toxic in contact with skin, toxic if swallowed. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Hexafluoroacetone?

Hexafluoroacetone is usually classified under HS code 291479 (Halogenated, sulphonated, nitrated or nitrosated derivatives, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hexafluoroacetone?

CompoundList lists 11 suppliers of Hexafluoroacetone in China, United States and Russia. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Hexafluoroacetone?

Suppliers quote Hexafluoroacetone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Hexafluoroacetone

Get quotes for Hexafluoroacetone

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell Hexafluoroacetone
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of Hexafluoroacetone with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/hexafluoroacetone-684-16-2" title="Hexafluoroacetone structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Aldehydes and ketones or HS code 291479

11 suppliers
Free quotes, contact stays private
Get quotes