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Cardiovascular and metabolic drugs

Hydrochlorothiazide

Also known as Esidrix, HCTZ, Hypothiazide

CAS 58-93-5Formula C7H8ClN3O4S2Molar mass 297.75 g/molEC 200-403-3
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 169 suppliers listed Drug substance
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Hydrochlorothiazide chemical structure, C7H8ClN3O4S2, CAS 58-93-5
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
White, or practically white crystalline powder
Melting point
273 to 275
Density
1.693 g/cm³
Solubility
In water, 722 mg/L at 25 °C
HS code
293590
Category
Cardiovascular and metabolic drugs
Illustrative photo, off-white crystalline powder in fibre drums in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Hydrochlorothiazide?

Plain description, key identifiers and synonyms

Hydrochlorothiazide is a benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure. It has a role as a diuretic, an antihypertensive agent, a xenobiotic and an environmental contaminant. It is a sulfonamide, an organochlorine compound and a benzothiadiazine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide
CAS number
58-93-5 CAS number cross-checkedOther or deprecated CAS: 125727-50-6, 8049-49-8
EC number
200-403-3
Molecular formula
C7H8ClN3O4S2
UNII
0J48LPH2TH
MDL number
MFCD00051765
InChIKey
JZUFKLXOESDKRF-UHFFFAOYSA-N
InChI
InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
SMILES (canonical and isomeric)
C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl

Synonyms

  • Esidrix
  • HCTZ
  • Hypothiazide
  • Vetidrex
  • Hidrotiazida
  • Idrotiazide
  • Megadiuril
  • Servithiazid
  • Newtolide
  • Oretic
  • Chlorosulthiadil
  • Aquarius
  • Esidrex
  • Dichlotiazid
  • Dichlotride
  • Hydrochlorothiazid
  • Hydrodiuretic
  • Hydrosaluric
  • Hypothiazid
  • Apresazide
  • Aquarills
  • Diclotride
  • Disalunil
  • Maschitt
  • Thiuretic
Show all 39 synonyms
  • Drenol
  • Hidril
  • Hydril
  • Nefrix
  • Hidrochlortiazid
  • Hydro-Diuril
  • Hydro-Aquil
  • Jen-Diril
  • Carozide
  • Dihydrochlorothiazide
  • Bremil
  • HydroDIURIL
  • Dihydrochlorothiazid
  • Chlorzide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
White, or practically white crystalline powderexp.
Odour
Practically odorlessexp.
Taste
Slightly bitter tasteexp.
Melting point
273 to 275exp.
Density
1.693 g/cm³exp.
Solubility
In water, 722 mg/L at 25 °Cexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
297.75 g/molcalc.
Exact mass
296.9645 Dacalc.
LogP (octanol/water)
-0.35calc.
Topological polar surface area
118.4 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
1calc.
Heavy atoms
17calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.14calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=S1(=O)NCNc2ccccc21

O=S1(=O)NCNc2ccccc21

2 rings, 12 atoms, the 2H-1,2,4-Benzothiadiazine, 3,4-dihydro-, 1,1-dioxide ring system.

123 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H317May cause an allergic skin reaction.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H372Causes damage to organs through prolonged or repeated exposure.
Precautionary statements (20)
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Hydrochlorothiazide suppliers

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All 169 suppliers
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Where suppliers are based

169 suppliers in 31 countries

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Hydrochlorothiazide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Veterinary medication:.

Antihypertensive Agents, Diuretics, Sodium Chloride Symporter Inhibitors.

Use classes: Pharmaceuticals, Cardiovascular system.

Industries and functions

Pharmacological actions

  • Antihypertensive Agents
  • Diuretics
  • Sodium Chloride Symporter Inhibitors

Roles

  • antiatherosclerotic agent
  • antihypertensive agent
  • cardiovascular drug
  • diuretic
  • environmental contaminant
  • hepatoprotective agent
  • hypoglycemic agent
  • pharmaceutical
  • protective agent
  • renoprotective agent
  • xenobiotic

Functional uses

  • Pharmaceutical

Pharmacology

Hydrochlorothiazide is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.

How it is made

Hydrochlorothiazide is synthesized by either the reaction of para-formaldehyde with 5-chloro-2,4-disulfamoylaniline in nonaqueous media, or the reaction of formaldehyde with 6-chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine-1,1-dioxide in aqueous alkaline solution.

Chlorothiazide can be reduced electrolytically or with sodium borohydride or catalytically. ... 3-Chloro-4,6-disulfamoylaniline can be cyclized with formaldehyde to give hydrochlorothiazide.

Preparation: ... Jones, Novello, United States of America patent 3025292 (1962 to Merck & Co), de Stevens, Werner, United States of America patent 3163645 (1964 to Ciba), Klosa, German patent 1163332 (1964), J. S. Irons, T. M. Cook, United States of America patent 3164588 (1965 to Merck & Co).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Hydrochlorothiazide is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Hydrochlorothiazide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Hydrochlorothiazide, based on the data on this page

What is Hydrochlorothiazide?

Hydrochlorothiazide is a benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.

What is the CAS number of Hydrochlorothiazide?

The CAS registry number of Hydrochlorothiazide is 58-93-5. Other or deprecated CAS numbers: 125727-50-6, 8049-49-8.

What is the molecular formula and weight of Hydrochlorothiazide?

The molecular formula of Hydrochlorothiazide is C7H8ClN3O4S2 and its molar mass is 297.75 g/mol.

What is Hydrochlorothiazide used for?

Veterinary medication:. Antihypertensive Agents, Diuretics, Sodium Chloride Symporter Inhibitors. Use classes: Pharmaceuticals, Cardiovascular system.

Is Hydrochlorothiazide hazardous?

Hydrochlorothiazide carries the GHS signal word "Danger". Main hazards: harmful if swallowed, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Hydrochlorothiazide?

Hydrochlorothiazide is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Hydrochlorothiazide?

CompoundList lists 169 suppliers of Hydrochlorothiazide in China, India, United States, Germany and 27 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Hydrochlorothiazide in India?

39 suppliers in India list Hydrochlorothiazide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Hydrochlorothiazide?

Suppliers quote Hydrochlorothiazide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Hydrochlorothiazide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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