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Heterocyclic building blocks

Ibudilast

Also known as Ketas, Ibudilastum, 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one

CAS 50847-11-5Formula C14H18N2OMolar mass 230.31 g/molEC 637-150-7
GHS signal word: Warning. Pictograms: Harmful or irritant 30 suppliers listed
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Ibudilast chemical structure, C14H18N2O, CAS 50847-11-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
50847-11-5
Formula
C14H18N2O
Molar mass
230.31 g/mol
EC number
637-150-7
HS code
293399
Category
Heterocyclic building blocks

What is Ibudilast?

Plain description, key identifiers and synonyms

Ibudilast is a pyrazolopyridine.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
CAS number
50847-11-5 CAS number cross-checked
EC number
637-150-7
Molecular formula
C14H18N2O
UNII
M0TTH61XC5
MDL number
MFCD00864808
InChIKey
ZJVFLBOZORBYFE-UHFFFAOYSA-N
InChI
InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
SMILES (canonical and isomeric)
CC(C)C1=NN2C=CC=CC2=C1C(=O)C(C)C

Synonyms

  • Ketas
  • Ibudilastum
  • 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
  • 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine
  • 3-Isobutyryl-2-isopropylpyrazolo(1,5-a)pyridine
  • AV 411
  • 1-(2-Isopropylpyrazolo(1,5-a)pyridin-3-yl)-2-methyl-1-propanone
  • 2-methyl-1-(2-propan-2-ylpyrazolo(1,5-a)pyridin-3-yl)propan-1-one
  • 1-(2-isopropylpyrazolo(1,5-alpha)pyridin-3-yl)-2-methyl-1-propanone
  • 1-(2-(1-Methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-2-methylpropan-1-one
  • Ke Tas
  • Eyevinal
  • 1-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one
  • Ketas (TN)
  • Tocris-1694
  • 1-Propanone, 2-methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-
  • 2-Isopropyl-3-isobutyrylpyrazolo(1,5-a)pyridine
  • 2-Methyl-1-[2-(Propan-2-Yl)pyrazolo[1,5-A]pyridin-3-Yl]propan-1-One
  • 2-methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone
  • KC-404, AV-411, MN-166
  • 2-isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine
  • 1-Propanone, 2-methyl-1-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-
  • Pinatos
  • Ibudilast (JAN/INN)
  • Ibudilast?
Show all 31 synonyms
  • Pyrazolo(1,5-a)pyridine, 3-isobutyryl-2-isopropyl-
  • Ibudilast (Standard)
  • 1-(2-Isopr
  • Ibudilast (JP17/INN)
  • Ibudilast (JP18/INN)
  • 5-24-03-00396 (Beilstein Handbook Reference)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
230.31 g/molcalc.
Exact mass
230.1419 Dacalc.
LogP (octanol/water)
3.3calc.
Topological polar surface area
34.37 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
3calc.
Heavy atoms
17calc.
Rings
2calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.43calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccn2nccc2c1

c1ccn2nccc2c1

2 rings, 9 atoms, the Pyrazolo(1,5-a)pyridine ring system.

1,603 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (19)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Ibudilast suppliers

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Where suppliers are based

30 suppliers in 6 countries

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Ibudilast price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Bronchodilator Agents
  • Phosphodiesterase Inhibitors
  • Platelet Aggregation Inhibitors
  • Vasodilator Agents

Roles

  • analgesic
  • anticoronaviral agent
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • immunomodulator
  • immunosuppressive agent
  • pharmaceutical

Pharmacology

Ibudilast is an orally bioavailable inhibitor of cyclic nucleotide phosphodiesterase (PDE), mainly PDE-3, -4, -10, and -11, with anti-(neuro)inflammatory, vasorelaxant, bronchodilator, analgesic, neuroprotective and potential anti-tumor activities. Ibudilast (IBD) is able to cross the blood-brain barrier (BBB).

Read more

Upon administration, IBD exerts its potential anti-tumor activity against glioblastoma multiforme (GBM) cells by inhibiting PDE-4 and the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF), which results in a decrease in MIF, its receptor CD74, and AKT expression, and attenuates the immunosuppressive properties of monocytic myeloid-derived suppressor cells (MDSCs) and reduces T-regulatory cells (Tregs). This causes GBM cell apoptosis and inhibits GBM cell proliferation. In addition, IBD reduces, through its inhibitory effect on various PDEs, the production of certain pro-inflammatory cytokines, such as interleukin-6 (IL-6), IL- 1beta, leukotriene B4, and tumor necrosis factor-alpha (TNF-a). IBD also upregulates the anti-inflammatory cytokine (IL-10), and promotes the production of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin-4 (NT-4). It also blocks toll-like receptor-4 (TLR-4), inhibits nitric oxide (NO) synthesis and reduces the level of reactive oxygen species (ROS).

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Ibudilast is traded under.

HS 2933.99Indicative HS code

Heterocyclic compounds with nitrogen hetero-atom(s) only, other

World exports in 2024
$12.1B
−31.0% vs 2023, imports $28.8B
2019 to 2024
Top exporters
  1. China30.5%
  2. India * partner reported16.3%
  3. Ireland9.0%
Top importers
  1. Slovenia31.7%
  2. Italy24.2%
  3. United States5.0%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Ibudilast is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Ibudilast, based on the data on this page

What is Ibudilast?

Ibudilast is a pyrazolopyridine.

What is the CAS number of Ibudilast?

The CAS registry number of Ibudilast is 50847-11-5.

What is the molecular formula and weight of Ibudilast?

The molecular formula of Ibudilast is C14H18N2O and its molar mass is 230.31 g/mol.

What is Ibudilast used for?

Known uses and roles of Ibudilast include building blocks in research and laboratory, screening compounds in research and laboratory, analgesic, anticoronaviral agent, antimicrobial agent and 9 more.

Is Ibudilast hazardous?

Ibudilast carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Ibudilast?

Ibudilast is usually classified under HS code 293399 (Heterocyclic compounds with nitrogen hetero-atom(s) only, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Ibudilast?

CompoundList lists 30 suppliers of Ibudilast in China, United States, Japan, Canada and 2 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Ibudilast?

Suppliers quote Ibudilast on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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