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Cosmetic antioxidants

Idebenone

Also known as Idebenona, Raxone, 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

CAS 58186-27-9Formula C19H30O5Molar mass 338.44 g/molEC 814-253-7
GHS signal word: Danger. Pictograms: Flammable, Harmful or irritant 70 suppliers listed
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Idebenone chemical structure, C19H30O5, CAS 58186-27-9
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
58186-27-9
Formula
C19H30O5
Molar mass
338.44 g/mol
Physical form
Solid
HS code
291469
Category
Cosmetic antioxidants
Illustrative photo, closed blue fibre drums on a pallet in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Idebenone?

Plain description, key identifiers and synonyms

Idebenone is a member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest, it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia. It has a role as a ferroptosis inhibitor and an antioxidant. It is a member of 1,4-benzoquinones and a primary alcohol.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
CAS number
58186-27-9 CAS number cross-checked
EC number
814-253-7
Molecular formula
C19H30O5
UNII
HB6PN45W4J
MDL number
MFCD00274552
INCI name
HYDROXYDECYL UBIQUINONE
InChIKey
JGPMMRGNQUBGND-UHFFFAOYSA-N
InChI
InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
SMILES (canonical and isomeric)
CC1=C(C(=O)C(=C(C1=O)OC)OC)CCCCCCCCCCO

Synonyms

  • Idebenona
  • Raxone
  • 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
  • Idebenonum
  • Sovrima
  • CV 2619
  • hydroxydecyl ubiquinone
  • Oristar hdu
  • 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone
  • 6-(10-Hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone
  • 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone
  • 2,5-Cyclohexadiene-1,4-dione, 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-
  • 2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone
  • noben
  • 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-p-benzoquinone
  • 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
  • Idebenone, >=98% (HPLC)
  • 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylbenzo-1,4-quinone
  • 5,6-Dimethoxy-2-(10-hydroxydecyl)-3-methyl-1,4-benzoquinone
  • 2-(10-hydroxydecyl)-6-methoxy-3-methyl-5-(trideuteriomethoxy)cyclohexa-2,5-diene-1,4-dione
  • 2,3-Dimethoxy-6-(10-hydroxydecyl)-5-methyl-1,4-benzoquinone
  • 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-cyclohexa-2,5-diene-1,4-dione
  • Idebenon
  • Avan
  • Cerestabon
Show all 34 synonyms
  • Nemocebral
  • Catena
  • Mnesis
  • Cerestabon,
  • Geniceral,
  • Lucenabol,
  • Daruma,
  • Esanic,
  • Idesol,

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Solidexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
338.44 g/molcalc.
Exact mass
338.2093 Dacalc.
LogP (octanol/water)
3.46calc.
Topological polar surface area
72.83 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
12calc.
Heavy atoms
24calc.
Rings
1calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.68calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC(=O)C=C1

O=C1C=CC(=O)C=C1

1 ring, 8 atoms, the Quinone ring system.

738 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS02: Flammable
Flammable
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H228Flammable solid.
  • H302Harmful if swallowed.
  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (23)
  • P210Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P240Ground and bond container and receiving equipment.
  • P241Use explosion-proof electrical, ventilating and lighting equipment.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P370 + P378In case of fire: Use appropriate media to extinguish.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Idebenone suppliers

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Where suppliers are based

70 suppliers in 12 countries

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Idebenone price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name HYDROXYDECYL UBIQUINONE(antioxidant)

Pharmacological actions

  • Antioxidants

Roles

  • antioxidant
  • ferroptosis inhibitor
  • immunomodulator
  • immunosuppressive agent
  • pharmaceutical

Functional uses

  • Antioxidant

Cosmetic functions

  • Antioxidant

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Idebenone is traded under.

HS 2914.69Indicative HS code

Quinones, other

World exports in 2024
$162M
−10.1% vs 2023, imports $157M
2019 to 2024
Top exporters
  1. China32.8%
  2. Netherlands29.3%
  3. Japan13.8%
Top importers
  1. United States23.0%
  2. India * partner reported16.1%
  3. Thailand7.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Idebenone is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Idebenone, based on the data on this page

What is Idebenone?

Idebenone is a member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6.

What is the CAS number of Idebenone?

The CAS registry number of Idebenone is 58186-27-9.

What is the molecular formula and weight of Idebenone?

The molecular formula of Idebenone is C19H30O5 and its molar mass is 338.44 g/mol.

What is Idebenone used for?

Known uses and roles of Idebenone include antioxidants in cosmetics and personal care, antioxidant, ferroptosis inhibitor, immunomodulator, immunosuppressive agent and 2 more.

Is Idebenone hazardous?

Idebenone carries the GHS signal word "Danger". Main hazards: flammable solid, harmful if swallowed, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Idebenone?

Idebenone is usually classified under HS code 291469 (Quinones, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Idebenone?

CompoundList lists 70 suppliers of Idebenone in China, United States, Hong Kong, United Kingdom and 8 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Idebenone in India?

1 supplier in India list Idebenone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Idebenone?

Suppliers quote Idebenone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Idebenone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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