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Screening compounds

Indisulam

Also known as N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide, N1-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide, indisulamum

CAS 165668-41-7Formula C14H12ClN3O4S2Molar mass 385.85 g/molEC 998-845-1
GHS signal word: Warning. Pictograms: Harmful or irritant 12 suppliers listed
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Indisulam chemical structure, C14H12ClN3O4S2, CAS 165668-41-7
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
165668-41-7
Formula
C14H12ClN3O4S2
Molar mass
385.85 g/mol
EC number
998-845-1
HS code
293590
Category
Screening compounds

What is Indisulam?

Plain description, key identifiers and synonyms

Indisulam is a chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development. It has a role as an EC 4.2.1.1 (carbonic anhydrase) inhibitor and an antineoplastic agent. It is a sulfonamide, an organochlorine compound and a chloroindole.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
CAS number
165668-41-7 CAS number cross-checked
EC number
998-845-1
Molecular formula
C14H12ClN3O4S2
UNII
WJ98J3NM90
MDL number
MFCD00945325
InChIKey
SETFNECMODOHTO-UHFFFAOYSA-N
InChI
InChI=1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
SMILES (canonical and isomeric)
C1=CC2=C(C(=C1)NS(=O)(=O)C3=CC=C(C=C3)S(=O)(=O)N)NC=C2Cl

Synonyms

  • N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
  • N1-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
  • indisulamum
  • N-(3-chloro-7-indolyl)-1,4-benzenedisulfonamide
  • N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide
  • N-(3-Chloro-7-indoyl)-1,4-Benzenedisulfonamide
  • 4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
  • indisulam (e7070)
  • N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide
  • 1,4-Benzenedisulfonamide, N1-(3-chloro-1H-indol-7-yl)-
  • N~1~-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
  • C14H12ClN3O4S2
  • Indisulam (IND)
  • 1,4-Benzenedisulfonamide, N-(3-chloro-1H-indol-7-yl)-
  • Indisulam (USAN/INN)
  • N~1~-(3-chloro-1H-indo
  • N-(3-Chloro-1H-indol-7-yl)benzene-1,4disulfonamide
  • Indisulam, >=98% (HPLC)
  • N4-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
  • N1-(3-Chloro-7-indolyl)benzene-1,4-disulfonamide
  • 1-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
  • N(1)-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
  • n-(3-chloro-1h-indol-7-yl)-4-sulfamoylbenzenesulfonamide
  • 1,4-Benzenedisulfonamide, N-(3-chloro-1H-indol-7-yl)

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
385.85 g/molcalc.
Exact mass
384.9958 Dacalc.
LogP (octanol/water)
2.27calc.
Topological polar surface area
122.1 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
4calc.
Heavy atoms
24calc.
Rings
3calc.
Aromatic rings
3calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=S(=O)(Nc1cccc2cc[nH]c12)c1ccccc1

O=S(=O)(Nc1cccc2cc[nH]c12)c1ccccc1

3 rings, 19 atoms.

60 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
Precautionary statements (9)
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Indisulam suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 12 suppliers
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Where suppliers are based

12 suppliers in 4 countries

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Indisulam price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Antineoplastic Agents
  • Carbonic Anhydrase Inhibitors

Roles

  • antineoplastic agent
  • enzyme inhibitor
  • pharmaceutical

Pharmacology

Indisulam is a novel sulfonamide compound with potential antineoplastic activity. Indisulam inhibits cyclin-dependent kinases (CDK), which regulate cell cycle progression and are usually over-expressed in cancerous cells. Inhibition of CDK results in G1/S phase arrest of the cell cycle, and may lead to induction of apoptosis and inhibition of tumor cell proliferation. In addition, indisulam also inhibits carbonic anhydrases (CA), especially isoforms IX and XII that are involved in aqueous humor production and are highly overexpressed in some types of cancers. Inhibition of CA IX and XII results in interference with ion exchange and pH in hypoxic tumor tissue and preventing chemoresistance to weakly basic antineoplastic agents.

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Indisulam is traded under.

HS 2935.90Indicative HS code

Sulphonamides, other

World exports in 2024
$5.64B
−11.0% vs 2023, imports $8.56B
2019 to 2024
Top exporters
  1. Ireland43.1%
  2. China12.0%
  3. India * partner reported9.5%
Top importers
  1. United States23.6%
  2. Slovenia19.1%
  3. Spain11.7%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Indisulam is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Indisulam, based on the data on this page

What is Indisulam?

Indisulam is a chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development.

What is the CAS number of Indisulam?

The CAS registry number of Indisulam is 165668-41-7.

What is the molecular formula and weight of Indisulam?

The molecular formula of Indisulam is C14H12ClN3O4S2 and its molar mass is 385.85 g/mol.

What is Indisulam used for?

Known uses and roles of Indisulam include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent, enzyme inhibitor, pharmaceutical and 2 more.

Is Indisulam hazardous?

Indisulam carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Indisulam?

Indisulam is usually classified under HS code 293590 (Sulphonamides, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Indisulam?

CompoundList lists 12 suppliers of Indisulam in China, United States, Canada and Germany. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Indisulam?

Suppliers quote Indisulam on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Indisulam

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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