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Screening compounds

Irx-5183

Also known as AGN 195183, RARa Agonist IRX5183, RARalpha Agonist IRX5183

CAS 367273-07-2Formula C22H22ClF2NO4Molar mass 437.87 g/mol
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Irx-5183 chemical structure, C22H22ClF2NO4, CAS 367273-07-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
367273-07-2
Formula
C22H22ClF2NO4
Molar mass
437.87 g/mol
HS code
292429
Category
Screening compounds

What is Irx-5183?

Plain description, key identifiers and synonyms

RARalpha Agonist IRX5183 is an orally bioavailable retinoid acid receptor alpha (RARalpha) agonist and vitamin A derivative, with potential antineoplastic activity. Upon administration, RARalpha agonist IRX5183 binds to and activates RARalpha, which promotes RARalpha-mediated signaling. This results in the transcription of RARalpha-responsive genes, which are responsible for cellular differentiation and proliferation. This results in the induction of cellular differentiation and apoptosis, and leads to the inhibition of cellular proliferation and tumorigenesis. RARalpha is a nuclear receptor and a member of the steroid receptor superfamily, reduced RARalpha signaling is correlated with cancer development in a variety of cancer cell types.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
4-[(4-chloro-3-hydroxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]-2,6-difluorobenzoic acid
CAS number
367273-07-2
Molecular formula
C22H22ClF2NO4
UNII
RC87L028HU
MDL number
MFCD18633237
InChIKey
PNAWUIKCVQSLFG-UHFFFAOYSA-N
InChI
InChI=1S/C22H22ClF2NO4/c1-21(2)5-6-22(3,4)16-12(21)9-11(18(27)17(16)23)19(28)26-10-7-13(24)15(20(29)30)14(25)8-10/h7-9,27H,5-6H2,1-4H3,(H,26,28)(H,29,30)
SMILES (canonical and isomeric)
CC1(CCC(C2=C1C=C(C(=C2Cl)O)C(=O)NC3=CC(=C(C(=C3)F)C(=O)O)F)(C)C)C

Synonyms

  • AGN 195183
  • RARa Agonist IRX5183
  • RARalpha Agonist IRX5183
  • IRX 5183
  • NRX 195183
  • 4-(4-chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-amido)-2,6-difluorobenzoic acid
  • 4-(4-Chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-carboxamido)-2,6-difluorobenzoic acid
  • Benzoic acid, 4-[[(4-chloro-5,6,7,8-tetrahydro-3-hydroxy-5,5,8,8-tetraMethyl-2-naphthalenyl)carbonyl]aMino]-2,6-difluoro-
  • Benzoic acid, 4-(((4-chloro-5,6,7,8-tetrahydro-3-hydroxy-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl)amino)-2,6-difluoro-
  • AGN 195183?
  • 4-[(4-Chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalene-2-carbonyl)-amino]-2,6-difluoro-benzoic acid
  • 4-[(4-chloro-3-hydroxy-5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]-2,6-difluorobenzoic acid
  • 4-[(8-chloro-7-hydroxy-1,1,4,4-tetramethyl-tetralin-6-carbonyl)amino]-2,6-difluoro-benzoic acid

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
437.87 g/molcalc.
Exact mass
437.1205 Dacalc.
LogP (octanol/water)
5.62calc.
Topological polar surface area
86.63 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
3calc.
Heavy atoms
30calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.36calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (1 violation)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C(Nc1ccccc1)c1ccc2c(c1)CCCC2

O=C(Nc1ccccc1)c1ccc2c(c1)CCCC2

3 rings, 19 atoms, the 2-Naphthalenecarboxamide, 5,6,7,8-tetrahydro-N-phenyl- ring system.

10 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Irx-5183 suppliers

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Irx-5183 price

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Uses and applications

What the substance is used for, by industry and function

Roles

  • antineoplastic agent
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Irx-5183 is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Irx-5183 is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Irx-5183, based on the data on this page

What is Irx-5183?

RARalpha Agonist IRX5183 is an orally bioavailable retinoid acid receptor alpha (RARalpha) agonist and vitamin A derivative, with potential antineoplastic activity. Upon administration, RARalpha agonist IRX5183 binds to and activates RARalpha, which promotes RARalpha-mediated signaling.

What is the CAS number of Irx-5183?

The CAS registry number of Irx-5183 is 367273-07-2.

What is the molecular formula and weight of Irx-5183?

The molecular formula of Irx-5183 is C22H22ClF2NO4 and its molar mass is 437.87 g/mol.

What is Irx-5183 used for?

Known uses and roles of Irx-5183 include building blocks in research and laboratory, screening compounds in research and laboratory, antineoplastic agent and pharmaceutical.

Is Irx-5183 hazardous?

No GHS hazard classification for Irx-5183 is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Irx-5183?

Irx-5183 is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Irx-5183?

Post a free request on CompoundList and suppliers of Irx-5183 will send you quotes. Your contact details stay private until you accept a quote.

What is the price of Irx-5183?

Suppliers quote Irx-5183 on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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