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Cosmetic colorants and hair dyes

Isatin

Also known as 1H-Indole-2,3-dione, Indole-2,3-dione, 2,3-Diketoindoline

CAS 91-56-5Formula C8H5NO2Molar mass 147.13 g/molEC 202-077-8
GHS signal word: Warning. Pictograms: Harmful or irritant 98 suppliers listed
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Isatin chemical structure, C8H5NO2, CAS 91-56-5
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
91-56-5
Formula
C8H5NO2
Molar mass
147.13 g/mol
EC number
202-077-8
HS code
293379
Category
Cosmetic colorants and hair dyes

What is Isatin?

Plain description, key identifiers and synonyms

Isatin is an indoledione that is the 2,3-diketo derivative of indole. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor and a plant metabolite.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1H-indole-2,3-dione
CAS number
91-56-5 CAS number cross-checkedOther or deprecated CAS: 1186480-61-4, 84788-92-1
EC number
202-077-8
Molecular formula
C8H5NO2
UNII
82X95S7M06
MDL number
MFCD00005718
INCI name
ISATIN
InChIKey
JXDYKVIHCLTXOP-UHFFFAOYSA-N
InChI
InChI=1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11)
SMILES (canonical and isomeric)
C1=CC=C2C(=C1)C(=O)C(=O)N2

Synonyms

  • 1H-Indole-2,3-dione
  • Indole-2,3-dione
  • 2,3-Diketoindoline
  • 2,3-Dioxoindoline
  • Pseudoisatin
  • Isotin
  • Isatic acid lactam
  • Isatinic acid anhydride
  • o-Aminobenzoylformic anhydride
  • 2,3-Dioxo-2,3-dihydroindole
  • 2,3-dihydro-1H-indole-2,3-dione
  • 2,3 Dioxoindoline
  • Indoline-2,3-dione
  • 2,3-Indolinedione
  • Isatine
  • Tribulin
  • 2,3-Ketoindoline
  • 2,3-dihydroindole-2,3-dione
  • 5-21-10-00221 (Beilstein Handbook Reference)
  • 1H-benzo[d]azoline-2,3-dione
  • 3-Indolinedione
  • indol-2
  • Indole-2
  • hydroxy-3-indolone
  • Isatin, p.a.
Show all 34 synonyms
  • 3-hydroxy-2-indolone
  • Isatin (Compound 1)
  • Isatin, technical grade
  • 2H-indole-2,3-dione
  • Isatin(NSC 9262)
  • 2,3-Dihydro-indole-2,3-dione
  • 2,3-dihydro-1H-indol-2,3-dione
  • doi:10.14272/JXDYKVIHCLTXOP-UHFFFAOYSA-N.1
  • Isatin, for spectrophotometric det. of proline and thiophene, >=99.0%

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
147.13 g/molcalc.
Exact mass
147.032 Dacalc.
LogP (octanol/water)
0.82calc.
Topological polar surface area
46.17 Ųcalc.
Hydrogen bond donors
1calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
0calc.
Heavy atoms
11calc.
Rings
2calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1Nc2ccccc2C1=O

O=C1Nc2ccccc2C1=O

2 rings, 11 atoms. This chemical is the scaffold itself.

802 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H317May cause an allergic skin reaction.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (9)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Isatin suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 98 suppliers
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Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

98 suppliers in 16 countries

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Isatin price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Cosmetic ingredient, INCI name ISATIN(hair dyeing)

Roles

  • enzyme inhibitor
  • eukaryotic metabolite
  • metabolite
  • plant metabolite

Functional uses

  • Dye

Cosmetic functions

  • Hair dyeing

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU cosmetic ingredient inventory
  • EU Cosmetics Regulation Annex III, restricted in cosmetics
    Name: ISATIN, Ref no: 210, Annex ref: III/210

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Isatin is traded under.

HS 2933.79Indicative HS code

Lactams, other lactams

World exports in 2024
$16.2B
−64.4% vs 2023, imports $15.4B
2019 to 2024
Top exporters
  1. Ireland37.0%
  2. France * partner reported15.6%
  3. Spain11.3%
Top importers
  1. Germany27.8%
  2. Ireland18.9%
  3. Panama * partner reported12.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Isatin is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Isatin, based on the data on this page

What is Isatin?

Isatin is an indoledione that is the 2,3-diketo derivative of indole. It has a role as an EC 1.4.3.4 (monoamine oxidase) inhibitor and a plant metabolite.

What is the CAS number of Isatin?

The CAS registry number of Isatin is 91-56-5. Other or deprecated CAS numbers: 1186480-61-4, 84788-92-1.

What is the molecular formula and weight of Isatin?

The molecular formula of Isatin is C8H5NO2 and its molar mass is 147.13 g/mol.

What is Isatin used for?

Known uses and roles of Isatin include colorants in cosmetics and personal care, enzyme inhibitor, eukaryotic metabolite, metabolite, plant metabolite and 2 more.

Is Isatin hazardous?

Isatin carries the GHS signal word "Warning". Main hazards: may cause an allergic skin reaction, harmful to aquatic life with long lasting effects. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Isatin?

Isatin is usually classified under HS code 293379 (Lactams, other lactams). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Isatin?

CompoundList lists 98 suppliers of Isatin in China, United States, United Kingdom, Canada and 12 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Isatin in India?

2 suppliers in India list Isatin on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Isatin?

Suppliers quote Isatin on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Isatin

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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