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Antibiotics and anti-infectives

Isoniazid

Also known as Isonicotinic acid hydrazide, Isonicotinohydrazide, pyridine-4-carbohydrazide

CAS 54-85-3Formula C6H7N3OMolar mass 137.14 g/molEC 200-214-6
GHS signal word: Warning. Pictograms: Harmful or irritant 128 suppliers listed Drug substance
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Isoniazid chemical structure, C6H7N3O, CAS 54-85-3
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Colorless or white crystals, or a white, crystalline powder
Melting point
171.4 °C
Flash point
>250
Solubility
In water, 1.4 × 10⁺⁵ mg/L at 25 °C
HS code
293339
Category
Antibiotics and anti-infectives
Illustrative photo, off-white powder in an open kraft paper sack in a chemical plant
Typical packagingIllustrative packaging image, not the actual product

What is Isoniazid?

Plain description, key identifiers and synonyms

Isoniazide is a carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine. It has a role as an antitubercular agent and a drug allergen. It is functionally related to an isonicotinic acid.

Isoniazid is an antibiotic for treatment of tuberculosis.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
pyridine-4-carbohydrazide
CAS number
54-85-3 CAS number cross-checked
EC number
200-214-6
Molecular formula
C6H7N3O
UNII
V83O1VOZ8L
MDL number
MFCD00006426
InChIKey
QRXWMOHMRWLFEY-UHFFFAOYSA-N
InChI
InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
SMILES (canonical and isomeric)
C1=CN=CC=C1C(=O)NN

Synonyms

  • Isonicotinic acid hydrazide
  • Isonicotinohydrazide
  • pyridine-4-carbohydrazide
  • Isoniazide
  • Rimifon
  • Nydrazid
  • Cotinazin
  • Dinacrin
  • Hydrazid
  • Iscotin
  • Mybasan
  • Cedin
  • Hidrasonil
  • Isonicotan
  • Nicotibina
  • Armazide
  • Ditubin
  • Ertuban
  • Isidrina
  • Isobicina
  • Laniazid
  • Neumandin
  • Hyzyd
  • Atcotibine
  • Isonidrin
Show all 39 synonyms
  • Isotebezid
  • Stanozide
  • Armazid
  • Eralon
  • Isolyn
  • Isonex
  • Isonico
  • Isozide
  • Neoteben
  • Niadrin
  • Nicetal
  • Nicizina
  • Niconyl
  • Nicozide

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Colorless or white crystals, or a white, crystalline powderexp.
Melting point
171.4 °Cexp.
Flash point
>250exp.
Solubility
In water, 1.4 × 10⁺⁵ mg/L at 25 °Cexp.
Vapour pressure
4.6 × 10⁻⁵ mm Hg at 25 °C /Estimated/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
137.14 g/molcalc.
Exact mass
137.0589 Dacalc.
LogP (octanol/water)
-0.31calc.
Topological polar surface area
68.01 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
3calc.
Rotatable bonds
1calc.
Heavy atoms
10calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccncc1

c1ccncc1

1 ring, 6 atoms, the Pyridine ring system.

118,162 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H302Harmful if swallowed.
  • H315Causes skin irritation.
Precautionary statements (10)
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Isoniazid suppliers

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All 128 suppliers
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Where suppliers are based

128 suppliers in 22 countries

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Isoniazid price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Used as a chemical intermediate for the synthesis of furonazide, glyconiazide, iproniazid.

Medication: Antitubercular Agents.

Veterinary medication:.

Pharmacological actions

  • Antitubercular Agents
  • Fatty Acid Synthesis Inhibitors

Roles

  • aetiopathogenetic role
  • allergen
  • anti-HIV agent
  • anti-ulcer drug
  • antibacterial agent
  • antibacterial drug
  • antiinfective agent
  • antimicrobial agent
  • antimicrobial drug
  • antimycobacterial drug
  • antineoplastic agent
  • antitubercular agent
  • antiviral agent
  • drug allergen
  • pharmaceutical

Pharmacology

Isoniazid is an Antimycobacterial.

How it is made

Oxidation of 4-methylpyridine or 4-ethylpyridine to isonicotinic acid, which is reacted as the methyl or ethyl ester with hydrazine or hydrazine hydrate

/It is/ prepared by condensing isonicotinic acid ethyl ester with hydrazine, from 4-cyanopyridine and hydrazine.

Prepared by condensing pyridine-4-carboxyethylate and hydrazine.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Hydrazides and their salts e.g. Isoniazid (INN), Ref no: 200, Annex ref: II/200
  • Active ingredient in FDA approved drug labels

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Isoniazid is traded under.

HS 2933.39Indicative HS code

Heterocyclic compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure…

World exports in 2024
$9.16B
−17.9% vs 2023, imports $10.6B
2019 to 2024
Top exporters
  1. China21.5%
  2. India * partner reported12.3%
  3. Ireland11.6%
Top importers
  1. Germany14.2%
  2. United States12.8%
  3. Brazil10.1%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Isoniazid is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Isoniazid, based on the data on this page

What is Isoniazid?

Isoniazide is a carbohydrazide obtained by formal condensation between pyridine-4-carboxylic acid and hydrazine. It has a role as an antitubercular agent and a drug allergen. It is functionally related to an isonicotinic acid.

What is the CAS number of Isoniazid?

The CAS registry number of Isoniazid is 54-85-3.

What is the molecular formula and weight of Isoniazid?

The molecular formula of Isoniazid is C6H7N3O and its molar mass is 137.14 g/mol.

What is Isoniazid used for?

Used as a chemical intermediate for the synthesis of furonazide, glyconiazide, iproniazid. Medication: Antitubercular Agents. Veterinary medication:.

Is Isoniazid hazardous?

Isoniazid carries the GHS signal word "Warning". Main hazards: harmful if swallowed, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of Isoniazid?

Isoniazid is usually classified under HS code 293339 (Compounds containing an unfused pyridine ring (whether or not hydrogenated) in the…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Isoniazid?

CompoundList lists 128 suppliers of Isoniazid in United States, China, India, Germany and 18 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Isoniazid in India?

7 suppliers in India list Isoniazid on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Isoniazid?

Suppliers quote Isoniazid on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Isoniazid

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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